Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| A | 0004033 | molecular_function | aldo-keto reductase (NADPH) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0016229 | molecular_function | steroid dehydrogenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0047086 | molecular_function | ketosteroid monooxygenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 401 |
| Chain | Residue |
| A | ARG200 |
| A | ARG263 |
| A | ASP297 |
| A | HOH548 |
| A | HOH621 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 402 |
| Chain | Residue |
| A | TYR216 |
| A | HOH562 |
| B | A1 |
| A | TYR55 |
| A | HIS117 |
| A | TYR118 |
| A | ASN167 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | GLY22 |
| A | THR23 |
| A | TYR24 |
| A | ASP50 |
| A | TYR55 |
| A | LEU268 |
| A | GLN270 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | PHE21 |
| A | GLY22 |
| A | THR23 |
| A | GLN270 |
| A | SER271 |
| A | HOH513 |
Functional Information from PROSITE/UniProt
| site_id | PS00062 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. LeeckdaglVKSIGVSNF |
| Chain | Residue | Details |
| A | LEU151-PHE168 | |
| site_id | PS00798 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHVDTAyayqvEeeIG |
| Chain | Residue | Details |
| A | GLY45-GLY62 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR55 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|Ref.6 |
| Chain | Residue | Details |
| A | GLY20 | |
| A | ASP50 | |
| A | TYR55 | |
| A | SER166 | |
| A | GLN190 | |
| A | TYR216 | |
| A | GLN270 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS117 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Lowers pKa of active site Tyr => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS84 | |
