6M6A
Cryo-EM structure of Thermus thermophilus Mfd in complex with RNA polymerase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| A | 0046983 | molecular_function | protein dimerization activity |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| B | 0046983 | molecular_function | protein dimerization activity |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0032549 | molecular_function | ribonucleoside binding |
| C | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0006351 | biological_process | DNA-templated transcription |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003899 | molecular_function | DNA-directed RNA polymerase activity |
| E | 0006351 | biological_process | DNA-templated transcription |
| E | 0034062 | molecular_function | 5'-3' RNA polymerase activity |
| M | 0000166 | molecular_function | nucleotide binding |
| M | 0000716 | biological_process | transcription-coupled nucleotide-excision repair, DNA damage recognition |
| M | 0003676 | molecular_function | nucleic acid binding |
| M | 0003677 | molecular_function | DNA binding |
| M | 0003678 | molecular_function | DNA helicase activity |
| M | 0003684 | molecular_function | damaged DNA binding |
| M | 0005524 | molecular_function | ATP binding |
| M | 0005737 | cellular_component | cytoplasm |
| M | 0006281 | biological_process | DNA repair |
| M | 0006355 | biological_process | regulation of DNA-templated transcription |
| M | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN D 2001 |
| Chain | Residue |
| D | CYS1112 |
| D | ARG1189 |
| D | CYS1194 |
| D | CYS1201 |
| D | CYS1204 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN D 2002 |
| Chain | Residue |
| D | PHE45 |
| D | ASP46 |
| D | THR31 |
| D | GLU40 |
| D | GLY43 |
| D | LEU44 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MG D 2003 |
| Chain | Residue |
| D | ASP739 |
| D | ASP741 |
| D | ASP743 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3AOI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3AOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01322","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"3AOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AOI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HSR","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
