6M3T

Crystal structure of the mouse endonuclease EndoG(H138A/C110A), space group P41212

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0003676	molecular_function	nucleic acid binding
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG A 301

Chain	Residue
A	GLY137
A	ALA138
A	GLN164
A	ASN169
A	HOH431

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG B 301

Chain	Residue
B	HOH421
B	ARG136
B	GLY137
B	ALA138
B	ASN169

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10047","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32095813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32192768","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32095813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32192768","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6LYF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NJT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Essential for catalytic activity","evidences":[{"source":"PubMed","id":"32192768","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q14249","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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