6M3S
Dimeric isocitrate dehydrogenase from Xanthomonas campestris pv. campestris 8004
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004449 | molecular_function | isocitrate dehydrogenase (NAD+) activity |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006102 | biological_process | isocitrate metabolic process |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004449 | molecular_function | isocitrate dehydrogenase (NAD+) activity |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006102 | biological_process | isocitrate metabolic process |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | LYS67 |
| A | HIS263 |
| A | GLY264 |
| A | SER265 |
| A | ALA266 |
| A | ASP268 |
| A | ILE269 |
| A | ASN276 |
| A | HOH534 |
| A | HOH543 |
| A | HOH582 |
| A | PRO69 |
| A | HOH590 |
| B | ASN176 |
| B | ILE205 |
| B | ASN208 |
| B | GOL404 |
| B | HOH540 |
| A | LEU70 |
| A | THR71 |
| A | THR72 |
| A | ASN82 |
| A | LEU244 |
| A | GLU260 |
| A | VAL262 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | GLY123 |
| A | ALA124 |
| A | THR226 |
| A | ASN227 |
| A | LEU228 |
| A | PHE229 |
| site_id | AC4 |
| Number of Residues | 29 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| A | ASN176 |
| A | ILE205 |
| A | ASN208 |
| A | HOH577 |
| B | ILE13 |
| B | LYS67 |
| B | PRO69 |
| B | LEU70 |
| B | THR71 |
| B | THR72 |
| B | ASN82 |
| B | LEU244 |
| B | GLU260 |
| B | VAL262 |
| B | HIS263 |
| B | GLY264 |
| B | SER265 |
| B | ALA266 |
| B | ASP268 |
| B | ILE269 |
| B | ALA275 |
| B | ASN276 |
| B | HOH508 |
| B | HOH532 |
| B | HOH539 |
| B | HOH556 |
| B | HOH560 |
| B | HOH574 |
| B | HOH583 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| B | GLY123 |
| B | ALA124 |
| B | THR226 |
| B | ASN227 |
| B | LEU228 |
| B | PHE229 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 404 |
| Chain | Residue |
| A | GLY243 |
| A | LEU244 |
| A | ASP317 |
| A | NAD401 |
| B | MET211 |
| B | ARG216 |
| B | HOH501 |
Functional Information from PROSITE/UniProt
| site_id | PS00470 |
| Number of Residues | 20 |
| Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NLFGDIiSDlcAglv.GGLGL |
| Chain | Residue | Details |
| A | ASN227-LEU246 |
