Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6M2R

X-ray structure of a functional Drosophila dopamine transporter in L-norepinephrine bound form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue DMU A 701

Chain	Residue
A	ARG133
A	PHE136
A	ALA137
A	PRO144
A	TYR219
A	ASP238
A	LEU241
L	GLN157

site_id	AC2
Number of Residues	4
Details	binding site for residue Y01 A 702

Chain	Residue
A	PHE357
A	GLY516
A	TYR518
A	ILE78

site_id	AC3
Number of Residues	5
Details	binding site for residue CLR A 703

Chain	Residue
A	ILE41
A	LEU270
A	TYR273
A	LEU277
A	ILE351

site_id	AC4
Number of Residues	3
Details	binding site for residue LNR A 704

Chain	Residue
A	ASP121
A	PHE325
A	GLY425

site_id	AC5
Number of Residues	4
Details	binding site for residue CL A 705

Chain	Residue
A	TYR69
A	GLN316
A	SER320
A	SER356

site_id	AC6
Number of Residues	5
Details	binding site for residue NA A 706

Chain	Residue
A	ALA44
A	ASN49
A	SER320
A	ASN352
A	HOH808

site_id	AC7
Number of Residues	6
Details	binding site for residue NA A 707

Chain	Residue
A	GLY42
A	VAL45
A	ASP46
A	LEU417
A	ASP420
A	SER421

site_id	AC8
Number of Residues	1
Details	binding site for residue D10 A 709

Chain	Residue
A	PHE577

site_id	AC9
Number of Residues	1
Details	binding site for residue D10 A 710

Chain	Residue
A	GLY538

site_id	AD1
Number of Residues	3
Details	binding site for residue NA L 301

Chain	Residue
L	GLN6
L	SER101
L	GLY102

site_id	AD2
Number of Residues	4
Details	binding site for residue NA L 302

Chain	Residue
L	GLN6
L	MET21
L	THR22
L	THR103

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR193-HIS199

site_id	PS00610
Number of Residues	15
Details	NA_NEUROTRAN_SYMP_1 Sodium:neurotransmitter symporter family signature 1. WRFPYlcykNGGGaF

Chain	Residue	Details
A	TRP51-PHE65

site_id	PS00754
Number of Residues	21
Details	NA_NEUROTRAN_SYMP_2 Sodium:neurotransmitter symporter family signature 2. FFfaSFTnsLPWtsCnniwNT

Chain	Residue	Details
A	PHE134-THR154

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"24037379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25961798","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	68
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"24037379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25961798","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"24037379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25961798","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	69
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"24037379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25961798","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	30
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"24037379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25961798","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"24037379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25961798","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"24037379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25961798","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"24037379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"24037379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"24037379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"24037379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"24037379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"24037379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"24037379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24037379","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XP1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PDB","id":"4XP1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; atypical","evidences":[{"source":"PubMed","id":"25970245","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XP1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)