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6M1H

CryoEM structure of human PAC1 receptor in complex with maxadilan

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0004930molecular_functionG protein-coupled receptor activity
A0004999molecular_functionvasoactive intestinal polypeptide receptor activity
A0007166biological_processcell surface receptor signaling pathway
A0007186biological_processG protein-coupled receptor signaling pathway
A0016020cellular_componentmembrane
B0005576cellular_componentextracellular region
B0042311biological_processvasodilation
D0005515molecular_functionprotein binding
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
D0016020cellular_componentmembrane
D0031681molecular_functionG-protein beta-subunit binding
D0045202cellular_componentsynapse
D0048144biological_processfibroblast proliferation
D0070062cellular_componentextracellular exosome
D0071380biological_processcellular response to prostaglandin E stimulus
D0071870biological_processcellular response to catecholamine stimulus
E0001750cellular_componentphotoreceptor outer segment
E0003924molecular_functionGTPase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005765cellular_componentlysosomal membrane
E0005829cellular_componentcytosol
E0005834cellular_componentheterotrimeric G-protein complex
E0005886cellular_componentplasma membrane
E0007165biological_processsignal transduction
E0007186biological_processG protein-coupled receptor signaling pathway
E0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
E0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
E0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
E0007265biological_processRas protein signal transduction
E0008283biological_processcell population proliferation
E0016020cellular_componentmembrane
E0030159molecular_functionsignaling receptor complex adaptor activity
E0044877molecular_functionprotein-containing complex binding
E0045202cellular_componentsynapse
E0050909biological_processsensory perception of taste
E0051020molecular_functionGTPase binding
E0060041biological_processretina development in camera-type eye
E0070062cellular_componentextracellular exosome
E0071380biological_processcellular response to prostaglandin E stimulus
E0071870biological_processcellular response to catecholamine stimulus
E0097381cellular_componentphotoreceptor disc membrane
E1903561cellular_componentextracellular vesicle
F0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
F0003091biological_processrenal water homeostasis
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005834cellular_componentheterotrimeric G-protein complex
F0005886cellular_componentplasma membrane
F0007165biological_processsignal transduction
F0007186biological_processG protein-coupled receptor signaling pathway
F0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
F0007190biological_processactivation of adenylate cyclase activity
F0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
F0007608biological_processsensory perception of smell
F0010856molecular_functionadenylate cyclase activator activity
F0016020cellular_componentmembrane
F0016787molecular_functionhydrolase activity
F0019001molecular_functionguanyl nucleotide binding
F0031683molecular_functionG-protein beta/gamma-subunit complex binding
F0031748molecular_functionD1 dopamine receptor binding
F0032588cellular_componenttrans-Golgi network membrane
F0046872molecular_functionmetal ion binding
F0046907biological_processintracellular transport
F0048589biological_processdevelopmental growth
F0050796biological_processregulation of insulin secretion
F0050890biological_processcognition
F0060348biological_processbone development
F0060789biological_processhair follicle placode formation
F0070062cellular_componentextracellular exosome
F0070527biological_processplatelet aggregation
F0071377biological_processcellular response to glucagon stimulus
F0071380biological_processcellular response to prostaglandin E stimulus
F0071870biological_processcellular response to catecholamine stimulus
F0071880biological_processadenylate cyclase-activating adrenergic receptor signaling pathway
F0120162biological_processpositive regulation of cold-induced thermogenesis
Functional Information from PROSITE/UniProt
site_idPS00649
Number of Residues25
DetailsG_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CpgmWDnit.CWkpAhvgemvlvsCP
ChainResidueDetails
ACYS54-PRO78

site_idPS00650
Number of Residues16
DetailsG_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGFVVaVLYCFlNgeV
ChainResidueDetails
AGLN392-VAL407

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
ELEU70-SER84
EILE157-ILE171
ELEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues22
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
AARG177-ARG199
FASN54
FLEU197
FTHR204
FASP223
FASN292
FALA366

site_idSWS_FT_FI2
Number of Residues38
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AALA200-ASP207
AGLY275-LEU289
ASER354-PHE371

site_idSWS_FT_FI3
Number of Residues18
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
ATRP208-CYS226

site_idSWS_FT_FI4
Number of Residues51
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ALYS227-GLY248
AVAL313-ILE330
AGLY393-GLU406

site_idSWS_FT_FI5
Number of Residues25
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
ALEU249-TRP274

site_idSWS_FT_FI6
Number of Residues22
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
ATYR290-PRO312

site_idSWS_FT_FI7
Number of Residues22
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
ALEU331-ARG353

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
ASER372-GLN392

site_idSWS_FT_FI9
Number of Residues19
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
AVAL407-VAL426

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P70205
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues5
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN48
AASN60
AGLU138
APHE321
AVAL396

224004

PDB entries from 2024-08-21

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