Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6LYO

Crystal Structure of H296A mutant of Formylglycinamidine Synthetase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004642	molecular_function	phosphoribosylformylglycinamidine synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	binding site for residue ADP A 1301

Chain	Residue
A	VAL333
A	PRO676
A	ALA678
A	ASP679
A	GLU718
A	ASN722
A	SER886
A	MG1361
A	MG1362
A	MG1363
A	HOH1447
A	THR386
A	HOH1455
A	HOH1477
A	HOH1530
A	HOH1543
A	HOH1708
A	HOH1732
A	HOH1756
A	HOH1779
A	HOH1950
A	HOH2007
A	GLY387
A	HOH2010
A	HOH2019
A	HOH2099
A	HOH2214
A	TYR388
A	PHE389
A	LYS649
A	LEU652
A	VAL653
A	GLN668

site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 1302

Chain	Residue
A	ALA709
A	ARG713
A	ASP755
A	LYS758
A	GLU763
A	HOH1514
A	HOH1679
A	HOH1919

site_id	AC3
Number of Residues	10
Details	binding site for residue GOL A 1303

Chain	Residue
A	GLU648
A	THR650
A	TRP673
A	GLN674
A	GLU1005
A	LYS1009
A	ARG1168
A	HOH1476
A	HOH1478
A	HOH1876

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 1304

Chain	Residue
A	HIS902
A	GLY961
A	ARG978
A	ASP1012
A	HOH1432
A	HOH1668

site_id	AC5
Number of Residues	6
Details	binding site for residue GOL A 1305

Chain	Residue
A	ALA911
A	HIS953
A	TYR954
A	HOH1441
A	HOH1759
A	HOH2199

site_id	AC6
Number of Residues	8
Details	binding site for residue GOL A 1306

Chain	Residue
A	SER689
A	TYR690
A	TYR691
A	VAL1229
A	THR1230
A	GLU1231
A	HOH1446
A	HOH1542

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL A 1307

Chain	Residue
A	VAL432
A	THR581
A	GLU582
A	GLU583
A	HOH1436

site_id	AC8
Number of Residues	6
Details	binding site for residue GOL A 1308

Chain	Residue
A	GLN767
A	ASP859
A	VAL860
A	ALA861
A	HOH1420
A	HOH1820

site_id	AC9
Number of Residues	10
Details	binding site for residue GOL A 1309

Chain	Residue
A	GLU264
A	ALA267
A	PRO286
A	HIS288
A	GLN1004
A	GLU1007
A	GOL1337
A	HOH1574
A	HOH1705
A	HOH2098

site_id	AD1
Number of Residues	2
Details	binding site for residue GOL A 1310

Chain	Residue
A	HIS153
A	GLN154

site_id	AD2
Number of Residues	4
Details	binding site for residue GOL A 1311

Chain	Residue
A	ASN1251
A	ARG1253
A	HOH1764
A	HOH2167

site_id	AD3
Number of Residues	8
Details	binding site for residue GOL A 1312

Chain	Residue
A	GLY745
A	HIS746
A	LYS782
A	ARG784
A	GLU793
A	HOH1848
A	HOH2144
A	ALA744

site_id	AD4
Number of Residues	7
Details	binding site for residue GOL A 1313

Chain	Residue
A	ASP250
A	TYR251
A	GLU264
A	GLU1007
A	HOH1445
A	HOH1796
A	HOH2118

site_id	AD5
Number of Residues	6
Details	binding site for residue GOL A 1314

Chain	Residue
A	THR1175
A	GLN1176
A	ARG1221
A	HOH1419
A	HOH1734
A	HOH2406

site_id	AD6
Number of Residues	6
Details	binding site for residue GOL A 1315

Chain	Residue
A	PRO79
A	SER85
A	GLU107
A	ARG108
A	GOL1330
A	HOH1482

site_id	AD7
Number of Residues	6
Details	binding site for residue GOL A 1316

Chain	Residue
A	GLN347
A	PRO348
A	LYS638
A	ARG639
A	HIS642
A	HOH1524

site_id	AD8
Number of Residues	6
Details	binding site for residue GOL A 1317

Chain	Residue
A	ARG480
A	ARG571
A	PRO573
A	HOH1480
A	HOH1490
A	HOH1504

site_id	AD9
Number of Residues	6
Details	binding site for residue GOL A 1318

Chain	Residue
A	GLY913
A	ASP914
A	ASP915
A	HOH1536
A	HOH1696
A	HOH1775

site_id	AE1
Number of Residues	6
Details	binding site for residue GOL A 1319

Chain	Residue
A	ARG15
A	GLU368
A	ARG996
A	ARG1164
A	HOH1412
A	HOH1422

site_id	AE2
Number of Residues	1
Details	binding site for residue GOL A 1320

Chain	Residue
A	HIS835

site_id	AE3
Number of Residues	8
Details	binding site for residue GOL A 1321

Chain	Residue
A	VAL616
A	GLN617
A	GLY748
A	ASP750
A	HOH1407
A	HOH1409
A	HOH1522
A	HOH1880

site_id	AE4
Number of Residues	3
Details	binding site for residue GOL A 1322

Chain	Residue
A	ARG1221
A	VAL1229
A	ASN1242

site_id	AE5
Number of Residues	6
Details	binding site for residue GOL A 1323

Chain	Residue
A	LYS435
A	ASP529
A	VAL576
A	ILE577
A	GLY578
A	ASP579

site_id	AE6
Number of Residues	5
Details	binding site for residue GOL A 1324

Chain	Residue
A	HIS298
A	LYS409
A	SER780
A	SO41359
A	HOH1521

site_id	AE7
Number of Residues	6
Details	binding site for residue GOL A 1325

Chain	Residue
A	ARG1145
A	TRP1154
A	ARG1156
A	ARG1204
A	HIS1208
A	HOH1847

site_id	AE8
Number of Residues	6
Details	binding site for residue GOL A 1326

Chain	Residue
A	LYS732
A	GLU976
A	TRP984
A	GOL1332
A	HOH1493
A	HOH2395

site_id	AE9
Number of Residues	2
Details	binding site for residue GOL A 1327

Chain	Residue
A	TYR37
A	HOH1783

site_id	AF1
Number of Residues	5
Details	binding site for residue GOL A 1328

Chain	Residue
A	ARG472
A	ASP473
A	GOL1330
A	HOH1636
A	HOH2276

site_id	AF2
Number of Residues	8
Details	binding site for residue GOL A 1329

Chain	Residue
A	HIS219
A	ASN259
A	LYS292
A	GLU294
A	GLY775
A	LYS776
A	HOH1421
A	HOH1871

site_id	AF3
Number of Residues	11
Details	binding site for residue GOL A 1330

Chain	Residue
A	PRO79
A	SER85
A	PRO86
A	GLU137
A	GOL1315
A	GOL1328
A	HOH1467
A	HOH1482
A	HOH1636
A	HOH1747
A	HOH2204

site_id	AF4
Number of Residues	3
Details	binding site for residue GOL A 1331

Chain	Residue
A	GLU192
A	LYS196
A	ARG1079

site_id	AF5
Number of Residues	11
Details	binding site for residue GOL A 1332

Chain	Residue
A	ASP250
A	LYS732
A	TRP984
A	GLU987
A	GOL1326
A	HOH1440
A	HOH1556
A	HOH1755
A	HOH1892
A	HOH2258
A	HOH2275

site_id	AF6
Number of Residues	7
Details	binding site for residue GOL A 1333

Chain	Residue
A	GLU1121
A	HIS1125
A	GLU1146
A	LEU1147
A	ILE1148
A	HOH1434
A	HOH1800

site_id	AF7
Number of Residues	8
Details	binding site for residue GOL A 1334

Chain	Residue
A	TYR690
A	ARG812
A	VAL1268
A	TRP1277
A	GLY1278
A	GLU1279
A	HOH1653
A	HOH2425

site_id	AF8
Number of Residues	3
Details	binding site for residue GOL A 1335

Chain	Residue
A	ASN48
A	ASP49
A	HOH2292

site_id	AF9
Number of Residues	5
Details	binding site for residue GOL A 1336

Chain	Residue
A	PRO63
A	ALA64
A	ARG1200
A	GLU1202
A	HOH1647

site_id	AG1
Number of Residues	8
Details	binding site for residue GOL A 1337

Chain	Residue
A	GLU264
A	ARG994
A	PRO999
A	GLN1000
A	ASP1003
A	GOL1309
A	SO41357
A	HOH1550

site_id	AG2
Number of Residues	3
Details	binding site for residue EDO A 1338

Chain	Residue
A	ARG936
A	HOH1441
A	HOH1746

site_id	AG3
Number of Residues	2
Details	binding site for residue GOL A 1339

Chain	Residue
A	ALA949
A	ASP950

site_id	AG4
Number of Residues	4
Details	binding site for residue EDO A 1340

Chain	Residue
A	GLN29
A	HIS31
A	SER117
A	HOH1413

site_id	AG5
Number of Residues	10
Details	binding site for residue SO4 A 1341

Chain	Residue
A	HIS216
A	THR295
A	ALA296
A	ASN297
A	HIS298
A	SER778
A	HOH1549
A	HOH1765
A	HOH1819
A	HOH2228

site_id	AG6
Number of Residues	9
Details	binding site for residue SO4 A 1342

Chain	Residue
A	HIS1086
A	ARG1126
A	PRO1127
A	GLN1128
A	THR1129
A	HOH1492
A	HOH1568
A	HOH1588
A	HOH2308

site_id	AG7
Number of Residues	7
Details	binding site for residue SO4 A 1343

Chain	Residue
A	TRP305
A	ARG1159
A	ARG1164
A	HOH1471
A	HOH1609
A	HOH1748
A	HOH1797

site_id	AG8
Number of Residues	6
Details	binding site for residue SO4 A 1344

Chain	Residue
A	ARG812
A	LYS1228
A	VAL1229
A	HOH1446
A	HOH1630
A	HOH1684

site_id	AG9
Number of Residues	8
Details	binding site for residue SO4 A 1345

Chain	Residue
A	PRO1040
A	LYS1041
A	HIS1086
A	HOH1586
A	HOH1587
A	HOH1672
A	HOH1897
A	HOH2347

site_id	AH1
Number of Residues	7
Details	binding site for residue SO4 A 1346

Chain	Residue
A	SER12
A	ALA13
A	PHE14
A	ASN998
A	HIS1161
A	HOH1567
A	HOH1790

site_id	AH2
Number of Residues	8
Details	binding site for residue SO4 A 1347

Chain	Residue
A	GLN1176
A	GLN1183
A	GLY1184
A	MET1185
A	VAL1186
A	HOH1533
A	HOH1723
A	HOH1798

site_id	AH3
Number of Residues	3
Details	binding site for residue SO4 A 1348

Chain	Residue
A	ASN1113
A	ARG1115
A	HOH1839

site_id	AH4
Number of Residues	4
Details	binding site for residue SO4 A 1349

Chain	Residue
A	PRO356
A	GLU357
A	ARG358
A	HOH1437

site_id	AH5
Number of Residues	5
Details	binding site for residue SO4 A 1350

Chain	Residue
A	THR632
A	ILE633
A	HOH1424
A	HOH1754
A	HOH2187

site_id	AH6
Number of Residues	6
Details	binding site for residue SO4 A 1351

Chain	Residue
A	HIS216
A	GLU294
A	GLY504
A	ALA505
A	LYS776
A	HOH1694

site_id	AH7
Number of Residues	5
Details	binding site for residue SO4 A 1352

Chain	Residue
A	LYS833
A	HIS835
A	ARG858
A	HOH1604
A	HOH1923

site_id	AH8
Number of Residues	2
Details	binding site for residue SO4 A 1353

Chain	Residue
A	HIS68
A	THR69

site_id	AH9
Number of Residues	2
Details	binding site for residue SO4 A 1354

Chain	Residue
A	LEU448
A	GLU541

site_id	AI1
Number of Residues	5
Details	binding site for residue SO4 A 1355

Chain	Residue
A	GLN54
A	PHE1112
A	HIS1114
A	HOH1485
A	HOH1639

site_id	AI2
Number of Residues	4
Details	binding site for residue SO4 A 1356

Chain	Residue
A	ARG218
A	ASN223
A	LYS611
A	HOH1410

site_id	AI3
Number of Residues	2
Details	binding site for residue SO4 A 1357

Chain	Residue
A	ARG994
A	GOL1337

site_id	AI4
Number of Residues	2
Details	binding site for residue SO4 A 1358

Chain	Residue
A	PRO1032
A	TYR1033

site_id	AI5
Number of Residues	7
Details	binding site for residue SO4 A 1359

Chain	Residue
A	HIS216
A	HIS298
A	SER780
A	GOL1324
A	HOH1549
A	HOH1819
A	HOH1901

site_id	AI6
Number of Residues	5
Details	binding site for residue SO4 A 1360

Chain	Residue
A	PRO348
A	ASP630
A	ARG639
A	VAL846
A	ARG848

site_id	AI7
Number of Residues	6
Details	binding site for residue MG A 1361

Chain	Residue
A	ASP679
A	ASN722
A	ASP884
A	ADP1301
A	HOH1530
A	HOH1950

site_id	AI8
Number of Residues	6
Details	binding site for residue MG A 1362

Chain	Residue
A	GLU718
A	ADP1301
A	HOH1537
A	HOH1543
A	HOH1708
A	HOH1756

site_id	AI9
Number of Residues	5
Details	binding site for residue MG A 1363

Chain	Residue
A	ADP1301
A	HOH1447
A	HOH1477
A	HOH1732
A	HOH2007

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15301531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22683785","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24223728","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)