6LYM

Crystal structure of D657A mutant of formylglycinamidine synthetase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004642	molecular_function	phosphoribosylformylglycinamidine synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	binding site for residue ADP A 1301

Chain	Residue
A	VAL333
A	ALA678
A	ASP679
A	GLU718
A	ASN722
A	SER886
A	MG1302
A	MG1303
A	MG1304
A	HOH1433
A	HOH1437
A	THR386
A	HOH1460
A	HOH1523
A	HOH1537
A	HOH1542
A	HOH1544
A	HOH1577
A	HOH1593
A	HOH1597
A	HOH1629
A	HOH1632
A	GLY387
A	HOH1635
A	HOH1644
A	TYR388
A	PHE389
A	LYS649
A	LEU652
A	GLN668
A	PRO676

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 1302

Chain	Residue
A	ASP679
A	ASN722
A	ASP884
A	ADP1301
A	HOH1577
A	HOH1644

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 1303

Chain	Residue
A	GLU718
A	ADP1301
A	HOH1431
A	HOH1460
A	HOH1523
A	HOH1544

---

site_id	AC4
Number of Residues	5
Details	binding site for residue MG A 1304

Chain	Residue
A	ADP1301
A	HOH1433
A	HOH1437
A	HOH1542
A	HOH1629

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 A 1305

Chain	Residue
A	GLU294
A	GLY504
A	ALA505
A	HOH1415

---

site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 A 1306

Chain	Residue
A	THR295
A	HIS296
A	ASN297
A	HIS298
A	SER778

---

site_id	AC7
Number of Residues	5
Details	binding site for residue SO4 A 1307

Chain	Residue
A	TYR690
A	ARG812
A	LYS1228
A	VAL1229
A	HOH1448

---

site_id	AC8
Number of Residues	6
Details	binding site for residue SO4 A 1308

Chain	Residue
A	GLN1176
A	GLN1183
A	GLY1184
A	MET1185
A	VAL1186
A	HOH1576

---

site_id	AC9
Number of Residues	7
Details	binding site for residue SO4 A 1309

Chain	Residue
A	HIS1086
A	ARG1126
A	PRO1127
A	GLN1128
A	THR1129
A	HOH1425
A	HOH1618

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 A 1310

Chain	Residue
A	GLN767
A	ASP859
A	VAL860
A	ALA861

---

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 A 1311

Chain	Residue
A	VAL432
A	THR581
A	GLU582
A	GLU583

---

site_id	AD3
Number of Residues	6
Details	binding site for residue SO4 A 1312

Chain	Residue
A	TRP305
A	ARG1159
A	ARG1164
A	HOH1447
A	HOH1583
A	HOH1695

---

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 A 1313

Chain	Residue
A	PRO1040
A	LYS1041
A	HIS1086
A	HOH1422

---

site_id	AD5
Number of Residues	2
Details	binding site for residue SO4 A 1314

Chain	Residue
A	ASN1113
A	ARG1115

---

site_id	AD6
Number of Residues	5
Details	binding site for residue SO4 A 1315

Chain	Residue
A	HIS1161
A	SER12
A	ALA13
A	PHE14
A	ASN998

---

site_id	AD7
Number of Residues	2
Details	binding site for residue SO4 A 1316

Chain	Residue
A	HIS68
A	THR69

---

site_id	AD8
Number of Residues	3
Details	binding site for residue SO4 A 1317

Chain	Residue
A	ALA911
A	VAL952
A	HIS953

---

site_id	AD9
Number of Residues	2
Details	binding site for residue SO4 A 1318

Chain	Residue
A	HIS153
A	GLN154

---

site_id	AE1
Number of Residues	3
Details	binding site for residue SO4 A 1319

Chain	Residue
A	PRO356
A	GLU357
A	ARG358

---

site_id	AE2
Number of Residues	5
Details	binding site for residue SO4 A 1320

Chain	Residue
A	THR632
A	ILE633
A	HOH1420
A	HOH1496
A	HOH1778

---

site_id	AE3
Number of Residues	3
Details	binding site for residue SO4 A 1321

Chain	Residue
A	LYS833
A	HIS835
A	HOH1419

---

site_id	AE4
Number of Residues	7
Details	binding site for residue SO4 A 1322

Chain	Residue
A	VAL616
A	GLN617
A	PRO747
A	GLY748
A	HOH1432
A	HOH1532
A	HOH1622

---

site_id	AE5
Number of Residues	6
Details	binding site for residue GOL A 1323

Chain	Residue
A	LYS327
A	ARG479
A	ASN1051
A	VAL1054
A	GLU1055
A	HOH1428

---

site_id	AE6
Number of Residues	2
Details	binding site for residue EDO A 1324

Chain	Residue
A	ASN1251
A	ARG1253

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00419","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15301531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22683785","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24223728","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---