6LXE

DROSHA-DGCR8 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004525	molecular_function	ribonuclease III activity
A	0006364	biological_process	rRNA processing
A	0006396	biological_process	RNA processing
A	0031054	biological_process	pre-miRNA processing
B	0003723	molecular_function	RNA binding
B	0003725	molecular_function	double-stranded RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006974	biological_process	DNA damage response
B	0014069	cellular_component	postsynaptic density
B	0016604	cellular_component	nuclear body
B	0020037	molecular_function	heme binding
B	0030674	molecular_function	protein-macromolecule adaptor activity
B	0031053	biological_process	primary miRNA processing
B	0035861	cellular_component	site of double-strand break
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0046872	molecular_function	metal ion binding
B	0070877	cellular_component	microprocessor complex
B	0070878	molecular_function	primary miRNA binding
B	0072091	biological_process	regulation of stem cell proliferation
B	0098978	cellular_component	glutamatergic synapse
B	0140517	molecular_function	protein-RNA adaptor activity
B	2000633	biological_process	positive regulation of pre-miRNA processing
C	0003723	molecular_function	RNA binding
C	0003725	molecular_function	double-stranded RNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006974	biological_process	DNA damage response
C	0014069	cellular_component	postsynaptic density
C	0016604	cellular_component	nuclear body
C	0020037	molecular_function	heme binding
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031053	biological_process	primary miRNA processing
C	0035861	cellular_component	site of double-strand break
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0046872	molecular_function	metal ion binding
C	0070877	cellular_component	microprocessor complex
C	0070878	molecular_function	primary miRNA binding
C	0072091	biological_process	regulation of stem cell proliferation
C	0098978	cellular_component	glutamatergic synapse
C	0140517	molecular_function	protein-RNA adaptor activity
C	2000633	biological_process	positive regulation of pre-miRNA processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 1401

Chain	Residue
A	CYS561
A	HIS609
A	CYS676
A	PRO677
A	HIS680

---

site_id	AC2
Number of Residues	5
Details	binding site for residue ZN A 1402

Chain	Residue
A	HIS1026
A	CYS536
A	CYS538
A	HIS549
A	TYR1024

---

Functional Information from PROSITE/UniProt

site_id	PS00517
Number of Residues	9
Details	RNASE_3_1 Ribonuclease III family signature. ERLEFLGDA

Chain	Residue	Details
A	GLU966-ALA974
A	GLN1144-SER1152

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	126
Details	Domain: {"description":"RNase III 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26748718","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O67082","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O67082","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"15574589","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Important for activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---