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6LTO

cryo-EM structure of full length human Pannexin1

Functional Information from GO Data
ChainGOidnamespacecontents
A0002020molecular_functionprotease binding
A0002931biological_processresponse to ischemia
A0003779molecular_functionactin binding
A0005102molecular_functionsignaling receptor binding
A0005198molecular_functionstructural molecule activity
A0005243molecular_functiongap junction channel activity
A0005253molecular_functionmonoatomic anion channel activity
A0005262molecular_functioncalcium channel activity
A0005347molecular_functionATP transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0005921cellular_componentgap junction
A0006812biological_processmonoatomic cation transport
A0006816biological_processcalcium ion transport
A0007267biological_processcell-cell signaling
A0015267molecular_functionchannel activity
A0015867biological_processATP transport
A0016020cellular_componentmembrane
A0022829molecular_functionwide pore channel activity
A0022840molecular_functionleak channel activity
A0030154biological_processcell differentiation
A0032059cellular_componentbleb
A0032730biological_processpositive regulation of interleukin-1 alpha production
A0032731biological_processpositive regulation of interleukin-1 beta production
A0032732biological_processpositive regulation of interleukin-1 production
A0032991cellular_componentprotein-containing complex
A0033198biological_processresponse to ATP
A0044325molecular_functiontransmembrane transporter binding
A0044877molecular_functionprotein-containing complex binding
A0048477biological_processoogenesis
A0051015molecular_functionactin filament binding
A0055077molecular_functiongap junction hemi-channel activity
A0060907biological_processpositive regulation of macrophage cytokine production
A0070588biological_processcalcium ion transmembrane transport
A0097110molecular_functionscaffold protein binding
A0098656biological_processmonoatomic anion transmembrane transport
B0002020molecular_functionprotease binding
B0002931biological_processresponse to ischemia
B0003779molecular_functionactin binding
B0005102molecular_functionsignaling receptor binding
B0005198molecular_functionstructural molecule activity
B0005243molecular_functiongap junction channel activity
B0005253molecular_functionmonoatomic anion channel activity
B0005262molecular_functioncalcium channel activity
B0005347molecular_functionATP transmembrane transporter activity
B0005515molecular_functionprotein binding
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0005921cellular_componentgap junction
B0006812biological_processmonoatomic cation transport
B0006816biological_processcalcium ion transport
B0007267biological_processcell-cell signaling
B0015267molecular_functionchannel activity
B0015867biological_processATP transport
B0016020cellular_componentmembrane
B0022829molecular_functionwide pore channel activity
B0022840molecular_functionleak channel activity
B0030154biological_processcell differentiation
B0032059cellular_componentbleb
B0032730biological_processpositive regulation of interleukin-1 alpha production
B0032731biological_processpositive regulation of interleukin-1 beta production
B0032732biological_processpositive regulation of interleukin-1 production
B0032991cellular_componentprotein-containing complex
B0033198biological_processresponse to ATP
B0044325molecular_functiontransmembrane transporter binding
B0044877molecular_functionprotein-containing complex binding
B0048477biological_processoogenesis
B0051015molecular_functionactin filament binding
B0055077molecular_functiongap junction hemi-channel activity
B0060907biological_processpositive regulation of macrophage cytokine production
B0070588biological_processcalcium ion transmembrane transport
B0097110molecular_functionscaffold protein binding
B0098656biological_processmonoatomic anion transmembrane transport
C0002020molecular_functionprotease binding
C0002931biological_processresponse to ischemia
C0003779molecular_functionactin binding
C0005102molecular_functionsignaling receptor binding
C0005198molecular_functionstructural molecule activity
C0005243molecular_functiongap junction channel activity
C0005253molecular_functionmonoatomic anion channel activity
C0005262molecular_functioncalcium channel activity
C0005347molecular_functionATP transmembrane transporter activity
C0005515molecular_functionprotein binding
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0005921cellular_componentgap junction
C0006812biological_processmonoatomic cation transport
C0006816biological_processcalcium ion transport
C0007267biological_processcell-cell signaling
C0015267molecular_functionchannel activity
C0015867biological_processATP transport
C0016020cellular_componentmembrane
C0022829molecular_functionwide pore channel activity
C0022840molecular_functionleak channel activity
C0030154biological_processcell differentiation
C0032059cellular_componentbleb
C0032730biological_processpositive regulation of interleukin-1 alpha production
C0032731biological_processpositive regulation of interleukin-1 beta production
C0032732biological_processpositive regulation of interleukin-1 production
C0032991cellular_componentprotein-containing complex
C0033198biological_processresponse to ATP
C0044325molecular_functiontransmembrane transporter binding
C0044877molecular_functionprotein-containing complex binding
C0048477biological_processoogenesis
C0051015molecular_functionactin filament binding
C0055077molecular_functiongap junction hemi-channel activity
C0060907biological_processpositive regulation of macrophage cytokine production
C0070588biological_processcalcium ion transmembrane transport
C0097110molecular_functionscaffold protein binding
C0098656biological_processmonoatomic anion transmembrane transport
D0002020molecular_functionprotease binding
D0002931biological_processresponse to ischemia
D0003779molecular_functionactin binding
D0005102molecular_functionsignaling receptor binding
D0005198molecular_functionstructural molecule activity
D0005243molecular_functiongap junction channel activity
D0005253molecular_functionmonoatomic anion channel activity
D0005262molecular_functioncalcium channel activity
D0005347molecular_functionATP transmembrane transporter activity
D0005515molecular_functionprotein binding
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0005921cellular_componentgap junction
D0006812biological_processmonoatomic cation transport
D0006816biological_processcalcium ion transport
D0007267biological_processcell-cell signaling
D0015267molecular_functionchannel activity
D0015867biological_processATP transport
D0016020cellular_componentmembrane
D0022829molecular_functionwide pore channel activity
D0022840molecular_functionleak channel activity
D0030154biological_processcell differentiation
D0032059cellular_componentbleb
D0032730biological_processpositive regulation of interleukin-1 alpha production
D0032731biological_processpositive regulation of interleukin-1 beta production
D0032732biological_processpositive regulation of interleukin-1 production
D0032991cellular_componentprotein-containing complex
D0033198biological_processresponse to ATP
D0044325molecular_functiontransmembrane transporter binding
D0044877molecular_functionprotein-containing complex binding
D0048477biological_processoogenesis
D0051015molecular_functionactin filament binding
D0055077molecular_functiongap junction hemi-channel activity
D0060907biological_processpositive regulation of macrophage cytokine production
D0070588biological_processcalcium ion transmembrane transport
D0097110molecular_functionscaffold protein binding
D0098656biological_processmonoatomic anion transmembrane transport
E0002020molecular_functionprotease binding
E0002931biological_processresponse to ischemia
E0003779molecular_functionactin binding
E0005102molecular_functionsignaling receptor binding
E0005198molecular_functionstructural molecule activity
E0005243molecular_functiongap junction channel activity
E0005253molecular_functionmonoatomic anion channel activity
E0005262molecular_functioncalcium channel activity
E0005347molecular_functionATP transmembrane transporter activity
E0005515molecular_functionprotein binding
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005886cellular_componentplasma membrane
E0005921cellular_componentgap junction
E0006812biological_processmonoatomic cation transport
E0006816biological_processcalcium ion transport
E0007267biological_processcell-cell signaling
E0015267molecular_functionchannel activity
E0015867biological_processATP transport
E0016020cellular_componentmembrane
E0022829molecular_functionwide pore channel activity
E0022840molecular_functionleak channel activity
E0030154biological_processcell differentiation
E0032059cellular_componentbleb
E0032730biological_processpositive regulation of interleukin-1 alpha production
E0032731biological_processpositive regulation of interleukin-1 beta production
E0032732biological_processpositive regulation of interleukin-1 production
E0032991cellular_componentprotein-containing complex
E0033198biological_processresponse to ATP
E0044325molecular_functiontransmembrane transporter binding
E0044877molecular_functionprotein-containing complex binding
E0048477biological_processoogenesis
E0051015molecular_functionactin filament binding
E0055077molecular_functiongap junction hemi-channel activity
E0060907biological_processpositive regulation of macrophage cytokine production
E0070588biological_processcalcium ion transmembrane transport
E0097110molecular_functionscaffold protein binding
E0098656biological_processmonoatomic anion transmembrane transport
F0002020molecular_functionprotease binding
F0002931biological_processresponse to ischemia
F0003779molecular_functionactin binding
F0005102molecular_functionsignaling receptor binding
F0005198molecular_functionstructural molecule activity
F0005243molecular_functiongap junction channel activity
F0005253molecular_functionmonoatomic anion channel activity
F0005262molecular_functioncalcium channel activity
F0005347molecular_functionATP transmembrane transporter activity
F0005515molecular_functionprotein binding
F0005783cellular_componentendoplasmic reticulum
F0005789cellular_componentendoplasmic reticulum membrane
F0005886cellular_componentplasma membrane
F0005921cellular_componentgap junction
F0006812biological_processmonoatomic cation transport
F0006816biological_processcalcium ion transport
F0007267biological_processcell-cell signaling
F0015267molecular_functionchannel activity
F0015867biological_processATP transport
F0016020cellular_componentmembrane
F0022829molecular_functionwide pore channel activity
F0022840molecular_functionleak channel activity
F0030154biological_processcell differentiation
F0032059cellular_componentbleb
F0032730biological_processpositive regulation of interleukin-1 alpha production
F0032731biological_processpositive regulation of interleukin-1 beta production
F0032732biological_processpositive regulation of interleukin-1 production
F0032991cellular_componentprotein-containing complex
F0033198biological_processresponse to ATP
F0044325molecular_functiontransmembrane transporter binding
F0044877molecular_functionprotein-containing complex binding
F0048477biological_processoogenesis
F0051015molecular_functionactin filament binding
F0055077molecular_functiongap junction hemi-channel activity
F0060907biological_processpositive regulation of macrophage cytokine production
F0070588biological_processcalcium ion transmembrane transport
F0097110molecular_functionscaffold protein binding
F0098656biological_processmonoatomic anion transmembrane transport
G0002020molecular_functionprotease binding
G0002931biological_processresponse to ischemia
G0003779molecular_functionactin binding
G0005102molecular_functionsignaling receptor binding
G0005198molecular_functionstructural molecule activity
G0005243molecular_functiongap junction channel activity
G0005253molecular_functionmonoatomic anion channel activity
G0005262molecular_functioncalcium channel activity
G0005347molecular_functionATP transmembrane transporter activity
G0005515molecular_functionprotein binding
G0005783cellular_componentendoplasmic reticulum
G0005789cellular_componentendoplasmic reticulum membrane
G0005886cellular_componentplasma membrane
G0005921cellular_componentgap junction
G0006812biological_processmonoatomic cation transport
G0006816biological_processcalcium ion transport
G0007267biological_processcell-cell signaling
G0015267molecular_functionchannel activity
G0015867biological_processATP transport
G0016020cellular_componentmembrane
G0022829molecular_functionwide pore channel activity
G0022840molecular_functionleak channel activity
G0030154biological_processcell differentiation
G0032059cellular_componentbleb
G0032730biological_processpositive regulation of interleukin-1 alpha production
G0032731biological_processpositive regulation of interleukin-1 beta production
G0032732biological_processpositive regulation of interleukin-1 production
G0032991cellular_componentprotein-containing complex
G0033198biological_processresponse to ATP
G0044325molecular_functiontransmembrane transporter binding
G0044877molecular_functionprotein-containing complex binding
G0048477biological_processoogenesis
G0051015molecular_functionactin filament binding
G0055077molecular_functiongap junction hemi-channel activity
G0060907biological_processpositive regulation of macrophage cytokine production
G0070588biological_processcalcium ion transmembrane transport
G0097110molecular_functionscaffold protein binding
G0098656biological_processmonoatomic anion transmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1862
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-CYS40
AARG128-ARG217
AALA288-CYS426
BMET1-CYS40
BARG128-ARG217
BALA288-CYS426
CMET1-CYS40
CARG128-ARG217
CALA288-CYS426
DMET1-CYS40
DARG128-ARG217
DALA288-CYS426
EMET1-CYS40
EARG128-ARG217
EALA288-CYS426
FMET1-CYS40
FARG128-ARG217
FALA288-CYS426
GMET1-CYS40
GARG128-ARG217
GALA288-CYS426

site_idSWS_FT_FI2
Number of Residues560
DetailsTRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00351
ChainResidueDetails
AILE41-GLY61
ALYS107-TRP127
ALEU218-SER238
ALEU267-LEU287
BILE41-GLY61
BLYS107-TRP127
BLEU218-SER238
BLEU267-LEU287
CILE41-GLY61
CLYS107-TRP127
CLEU218-SER238
CLEU267-LEU287
DILE41-GLY61
DLYS107-TRP127
DLEU218-SER238
DLEU267-LEU287
EILE41-GLY61
ELYS107-TRP127
ELEU218-SER238
ELEU267-LEU287
FILE41-GLY61
FLYS107-TRP127
FLEU218-SER238
FLEU267-LEU287
GILE41-GLY61
GLYS107-TRP127
GLEU218-SER238
GLEU267-LEU287

site_idSWS_FT_FI3
Number of Residues497
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ATHR62-HIS106
ASER239-LYS266
BTHR62-HIS106
BSER239-LYS266
CTHR62-HIS106
CSER239-LYS266
DTHR62-HIS106
DSER239-LYS266
ETHR62-HIS106
ESER239-LYS266
FTHR62-HIS106
FSER239-LYS266
GTHR62-HIS106
GSER239-LYS266

site_idSWS_FT_FI4
Number of Residues7
DetailsSITE: Cleavage; by CASP3 or CASP7 => ECO:0000269|PubMed:20944749
ChainResidueDetails
AASP376
BASP376
CASP376
DASP376
EASP376
FASP376
GASP376

site_idSWS_FT_FI5
Number of Residues14
DetailsMOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:Q9JIP4
ChainResidueDetails
DCYS347
ECYS40
ECYS347
FCYS40
FCYS347
GCYS40
GCYS347
ACYS40
ACYS347
BCYS40
BCYS347
CCYS40
CCYS347
DCYS40

site_idSWS_FT_FI6
Number of Residues7
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:30814251
ChainResidueDetails
ATYR199
BTYR199
CTYR199
DTYR199
ETYR199
FTYR199
GTYR199

site_idSWS_FT_FI7
Number of Residues7
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17715132, ECO:0000269|PubMed:30918116, ECO:0000269|PubMed:32494015, ECO:0000269|PubMed:33947837
ChainResidueDetails
AASN255
BASN255
CASN255
DASN255
EASN255
FASN255
GASN255

219869

PDB entries from 2024-05-15

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