6LTH

Structure of human BAF Base module

Functional Information from GO Data

Chain	GOid	namespace	contents
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0000776	cellular_component	kinetochore
I	0000785	cellular_component	chromatin
I	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
I	0001188	biological_process	RNA polymerase I preinitiation complex assembly
I	0001221	molecular_function	transcription coregulator binding
I	0001650	cellular_component	fibrillar center
I	0002039	molecular_function	p53 binding
I	0003407	biological_process	neural retina development
I	0003677	molecular_function	DNA binding
I	0003713	molecular_function	transcription coactivator activity
I	0003714	molecular_function	transcription corepressor activity
I	0003723	molecular_function	RNA binding
I	0004386	molecular_function	helicase activity
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005730	cellular_component	nucleolus
I	0006325	biological_process	chromatin organization
I	0006337	biological_process	nucleosome disassembly
I	0006338	biological_process	chromatin remodeling
I	0006355	biological_process	regulation of DNA-templated transcription
I	0006357	biological_process	regulation of transcription by RNA polymerase II
I	0007399	biological_process	nervous system development
I	0008094	molecular_function	ATP-dependent activity, acting on DNA
I	0008284	biological_process	positive regulation of cell population proliferation
I	0016020	cellular_component	membrane
I	0016363	cellular_component	nuclear matrix
I	0016514	cellular_component	SWI/SNF complex
I	0016586	cellular_component	RSC-type complex
I	0016787	molecular_function	hydrolase activity
I	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
I	0030177	biological_process	positive regulation of Wnt signaling pathway
I	0030308	biological_process	negative regulation of cell growth
I	0030957	molecular_function	Tat protein binding
I	0031492	molecular_function	nucleosomal DNA binding
I	0032991	cellular_component	protein-containing complex
I	0042393	molecular_function	histone binding
I	0043923	biological_process	positive regulation by host of viral transcription
I	0045582	biological_process	positive regulation of T cell differentiation
I	0045596	biological_process	negative regulation of cell differentiation
I	0045597	biological_process	positive regulation of cell differentiation
I	0045663	biological_process	positive regulation of myoblast differentiation
I	0045815	biological_process	transcription initiation-coupled chromatin remodeling
I	0045892	biological_process	negative regulation of DNA-templated transcription
I	0045893	biological_process	positive regulation of DNA-templated transcription
I	0045944	biological_process	positive regulation of transcription by RNA polymerase II
I	0050681	molecular_function	nuclear androgen receptor binding
I	0051091	biological_process	positive regulation of DNA-binding transcription factor activity
I	0060766	biological_process	negative regulation of androgen receptor signaling pathway
I	0070182	molecular_function	DNA polymerase binding
I	0070316	biological_process	regulation of G0 to G1 transition
I	0071564	cellular_component	npBAF complex
I	0071565	cellular_component	nBAF complex
I	0120162	biological_process	positive regulation of cold-induced thermogenesis
I	0140092	cellular_component	bBAF complex
I	0140288	cellular_component	GBAF complex
I	0140658	molecular_function	ATP-dependent chromatin remodeler activity
I	1901838	biological_process	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
I	1902459	biological_process	positive regulation of stem cell population maintenance
I	1902661	biological_process	positive regulation of glucose mediated signaling pathway
I	1902895	biological_process	positive regulation of miRNA transcription
I	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
I	2000781	biological_process	positive regulation of double-strand break repair
I	2000819	biological_process	regulation of nucleotide-excision repair
L	0000785	cellular_component	chromatin
L	0003677	molecular_function	DNA binding
L	0003713	molecular_function	transcription coactivator activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0006325	biological_process	chromatin organization
L	0006337	biological_process	nucleosome disassembly
L	0006338	biological_process	chromatin remodeling
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0007399	biological_process	nervous system development
L	0016514	cellular_component	SWI/SNF complex
L	0016922	molecular_function	nuclear receptor binding
L	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
L	0031491	molecular_function	nucleosome binding
L	0035060	cellular_component	brahma complex
L	0045582	biological_process	positive regulation of T cell differentiation
L	0045597	biological_process	positive regulation of cell differentiation
L	0045663	biological_process	positive regulation of myoblast differentiation
L	0045815	biological_process	transcription initiation-coupled chromatin remodeling
L	0045893	biological_process	positive regulation of DNA-templated transcription
L	0070316	biological_process	regulation of G0 to G1 transition
L	0071564	cellular_component	npBAF complex
L	0071565	cellular_component	nBAF complex
L	0140092	cellular_component	bBAF complex
L	1902459	biological_process	positive regulation of stem cell population maintenance
L	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
L	2000781	biological_process	positive regulation of double-strand break repair
L	2000819	biological_process	regulation of nucleotide-excision repair
M	0000228	cellular_component	nuclear chromosome
M	0000776	cellular_component	kinetochore
M	0000785	cellular_component	chromatin
M	0001164	molecular_function	RNA polymerase I core promoter sequence-specific DNA binding
M	0001188	biological_process	RNA polymerase I preinitiation complex assembly
M	0001650	cellular_component	fibrillar center
M	0001741	cellular_component	XY body
M	0001824	biological_process	blastocyst development
M	0001835	biological_process	blastocyst hatching
M	0002039	molecular_function	p53 binding
M	0003677	molecular_function	DNA binding
M	0003713	molecular_function	transcription coactivator activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005730	cellular_component	nucleolus
M	0006325	biological_process	chromatin organization
M	0006337	biological_process	nucleosome disassembly
M	0006338	biological_process	chromatin remodeling
M	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0007399	biological_process	nervous system development
M	0008285	biological_process	negative regulation of cell population proliferation
M	0015074	biological_process	DNA integration
M	0016363	cellular_component	nuclear matrix
M	0016514	cellular_component	SWI/SNF complex
M	0016586	cellular_component	RSC-type complex
M	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
M	0030957	molecular_function	Tat protein binding
M	0031492	molecular_function	nucleosomal DNA binding
M	0032991	cellular_component	protein-containing complex
M	0035060	cellular_component	brahma complex
M	0039692	biological_process	single stranded viral RNA replication via double stranded DNA intermediate
M	0042802	molecular_function	identical protein binding
M	0043073	cellular_component	germ cell nucleus
M	0043231	cellular_component	intracellular membrane-bounded organelle
M	0043923	biological_process	positive regulation by host of viral transcription
M	0045582	biological_process	positive regulation of T cell differentiation
M	0045597	biological_process	positive regulation of cell differentiation
M	0045663	biological_process	positive regulation of myoblast differentiation
M	0045815	biological_process	transcription initiation-coupled chromatin remodeling
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
M	0051091	biological_process	positive regulation of DNA-binding transcription factor activity
M	0070316	biological_process	regulation of G0 to G1 transition
M	0070365	biological_process	hepatocyte differentiation
M	0071564	cellular_component	npBAF complex
M	0071565	cellular_component	nBAF complex
M	0140092	cellular_component	bBAF complex
M	1901838	biological_process	positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
M	1902459	biological_process	positive regulation of stem cell population maintenance
M	1902661	biological_process	positive regulation of glucose mediated signaling pathway
M	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
M	2000781	biological_process	positive regulation of double-strand break repair
M	2000819	biological_process	regulation of nucleotide-excision repair
N	0000776	cellular_component	kinetochore
N	0000785	cellular_component	chromatin
N	0003713	molecular_function	transcription coactivator activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005694	cellular_component	chromosome
N	0006325	biological_process	chromatin organization
N	0006337	biological_process	nucleosome disassembly
N	0006338	biological_process	chromatin remodeling
N	0006357	biological_process	regulation of transcription by RNA polymerase II
N	0007399	biological_process	nervous system development
N	0016363	cellular_component	nuclear matrix
N	0016514	cellular_component	SWI/SNF complex
N	0016586	cellular_component	RSC-type complex
N	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
N	0031492	molecular_function	nucleosomal DNA binding
N	0032991	cellular_component	protein-containing complex
N	0035060	cellular_component	brahma complex
N	0042393	molecular_function	histone binding
N	0045582	biological_process	positive regulation of T cell differentiation
N	0045597	biological_process	positive regulation of cell differentiation
N	0045663	biological_process	positive regulation of myoblast differentiation
N	0045892	biological_process	negative regulation of DNA-templated transcription
N	0045893	biological_process	positive regulation of DNA-templated transcription
N	0070316	biological_process	regulation of G0 to G1 transition
N	0071564	cellular_component	npBAF complex
N	0071565	cellular_component	nBAF complex
N	0140092	cellular_component	bBAF complex
N	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
N	2000781	biological_process	positive regulation of double-strand break repair
N	2000819	biological_process	regulation of nucleotide-excision repair
O	0000776	cellular_component	kinetochore
O	0000785	cellular_component	chromatin
O	0003713	molecular_function	transcription coactivator activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005694	cellular_component	chromosome
O	0006325	biological_process	chromatin organization
O	0006337	biological_process	nucleosome disassembly
O	0006338	biological_process	chromatin remodeling
O	0006357	biological_process	regulation of transcription by RNA polymerase II
O	0007399	biological_process	nervous system development
O	0016363	cellular_component	nuclear matrix
O	0016514	cellular_component	SWI/SNF complex
O	0016586	cellular_component	RSC-type complex
O	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
O	0031492	molecular_function	nucleosomal DNA binding
O	0032991	cellular_component	protein-containing complex
O	0035060	cellular_component	brahma complex
O	0042393	molecular_function	histone binding
O	0045582	biological_process	positive regulation of T cell differentiation
O	0045597	biological_process	positive regulation of cell differentiation
O	0045663	biological_process	positive regulation of myoblast differentiation
O	0045892	biological_process	negative regulation of DNA-templated transcription
O	0045893	biological_process	positive regulation of DNA-templated transcription
O	0070316	biological_process	regulation of G0 to G1 transition
O	0071564	cellular_component	npBAF complex
O	0071565	cellular_component	nBAF complex
O	0140092	cellular_component	bBAF complex
O	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
O	2000781	biological_process	positive regulation of double-strand break repair
O	2000819	biological_process	regulation of nucleotide-excision repair
P	0000776	cellular_component	kinetochore
P	0000785	cellular_component	chromatin
P	0003682	molecular_function	chromatin binding
P	0003712	molecular_function	transcription coregulator activity
P	0003713	molecular_function	transcription coactivator activity
P	0005102	molecular_function	signaling receptor binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0006325	biological_process	chromatin organization
P	0006337	biological_process	nucleosome disassembly
P	0006338	biological_process	chromatin remodeling
P	0006357	biological_process	regulation of transcription by RNA polymerase II
P	0007399	biological_process	nervous system development
P	0008284	biological_process	positive regulation of cell population proliferation
P	0016363	cellular_component	nuclear matrix
P	0016514	cellular_component	SWI/SNF complex
P	0016586	cellular_component	RSC-type complex
P	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
P	0035060	cellular_component	brahma complex
P	0043231	cellular_component	intracellular membrane-bounded organelle
P	0045582	biological_process	positive regulation of T cell differentiation
P	0045596	biological_process	negative regulation of cell differentiation
P	0045597	biological_process	positive regulation of cell differentiation
P	0045663	biological_process	positive regulation of myoblast differentiation
P	0045815	biological_process	transcription initiation-coupled chromatin remodeling
P	0045893	biological_process	positive regulation of DNA-templated transcription
P	0060090	molecular_function	molecular adaptor activity
P	0070316	biological_process	regulation of G0 to G1 transition
P	0071398	biological_process	cellular response to fatty acid
P	0071564	cellular_component	npBAF complex
P	0071565	cellular_component	nBAF complex
P	0140288	cellular_component	GBAF complex
P	1902459	biological_process	positive regulation of stem cell population maintenance
P	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
P	2000781	biological_process	positive regulation of double-strand break repair
P	2000819	biological_process	regulation of nucleotide-excision repair
Q	0000228	cellular_component	nuclear chromosome
Q	0000776	cellular_component	kinetochore
Q	0000785	cellular_component	chromatin
Q	0003677	molecular_function	DNA binding
Q	0003682	molecular_function	chromatin binding
Q	0003713	molecular_function	transcription coactivator activity
Q	0003723	molecular_function	RNA binding
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0006325	biological_process	chromatin organization
Q	0006337	biological_process	nucleosome disassembly
Q	0006338	biological_process	chromatin remodeling
Q	0006357	biological_process	regulation of transcription by RNA polymerase II
Q	0007399	biological_process	nervous system development
Q	0008080	molecular_function	N-acetyltransferase activity
Q	0016363	cellular_component	nuclear matrix
Q	0016514	cellular_component	SWI/SNF complex
Q	0016586	cellular_component	RSC-type complex
Q	0016922	molecular_function	nuclear receptor binding
Q	0022008	biological_process	neurogenesis
Q	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
Q	0031492	molecular_function	nucleosomal DNA binding
Q	0032991	cellular_component	protein-containing complex
Q	0035060	cellular_component	brahma complex
Q	0045582	biological_process	positive regulation of T cell differentiation
Q	0045597	biological_process	positive regulation of cell differentiation
Q	0045663	biological_process	positive regulation of myoblast differentiation
Q	0045892	biological_process	negative regulation of DNA-templated transcription
Q	0045893	biological_process	positive regulation of DNA-templated transcription
Q	0070316	biological_process	regulation of G0 to G1 transition
Q	0071564	cellular_component	npBAF complex
Q	0071565	cellular_component	nBAF complex
Q	0140092	cellular_component	bBAF complex
Q	1902459	biological_process	positive regulation of stem cell population maintenance
Q	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
Q	2000781	biological_process	positive regulation of double-strand break repair
Q	2000819	biological_process	regulation of nucleotide-excision repair
R	0000122	biological_process	negative regulation of transcription by RNA polymerase II
R	0000785	cellular_component	chromatin
R	0003714	molecular_function	transcription corepressor activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005813	cellular_component	centrosome
R	0005829	cellular_component	cytosol
R	0006325	biological_process	chromatin organization
R	0006338	biological_process	chromatin remodeling
R	0006357	biological_process	regulation of transcription by RNA polymerase II
R	0006915	biological_process	apoptotic process
R	0007399	biological_process	nervous system development
R	0016514	cellular_component	SWI/SNF complex
R	0030071	biological_process	regulation of mitotic metaphase/anaphase transition
R	0043231	cellular_component	intracellular membrane-bounded organelle
R	0046872	molecular_function	metal ion binding
R	0062072	molecular_function	H3K9me3 modified histone binding
R	0070316	biological_process	regulation of G0 to G1 transition
R	0070577	molecular_function	lysine-acetylated histone binding
R	0071565	cellular_component	nBAF complex
R	0097190	biological_process	apoptotic signaling pathway
R	1902459	biological_process	positive regulation of stem cell population maintenance
R	1905454	biological_process	negative regulation of myeloid progenitor cell differentiation
R	2000045	biological_process	regulation of G1/S transition of mitotic cell cycle
R	2000781	biological_process	positive regulation of double-strand break repair
R	2000819	biological_process	regulation of nucleotide-excision repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN L 2301

Chain	Residue
L	HIS2019
L	HIS2021
L	HIS2090
L	CYS2094

---

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	22
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cdi..CgkrYknrpglsyHyahs.H

Chain	Residue	Details
R	CYS211-HIS232

---

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. SevFiqlpSrkelp..EYYelIrkpVdfkkIkerirnhk..Yrslndlekdvml.LcqNAqtF

Chain	Residue	Details
I	SER1482-PHE1539

---

site_id	PS01359
Number of Residues	80
Details	ZF_PHD_1 Zinc finger PHD-type signature. CsdCgrsghpsclqftpvmmaavktyrwqcieckccnicgtsenddql.LfCdd..Cdrg.YHmyCltpsmseppegs.................................WsChlC

Chain	Residue	Details
R	CYS295-CYS374

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	23
Details	ZN_FING: C2H2-type => ECO:0000255|PROSITE-ProRule:PRU00042

Chain	Residue	Details
R	TYR209-HIS232
O	SER283

---

site_id	SWS_FT_FI2
Number of Residues	60
Details	ZN_FING: PHD-type 1 => ECO:0000255|PROSITE-ProRule:PRU00146

Chain	Residue	Details
R	ASN270-CYS330
Q	ARG40
M	LYS108
M	LYS124
M	LYS161
L	SER1929

---

site_id	SWS_FT_FI3
Number of Residues	50
Details	ZN_FING: PHD-type 2 => ECO:0000255|PROSITE-ProRule:PRU00146

Chain	Residue	Details
R	CYS327-LEU377
O	SER302

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
R	ALA2
O	SER304
Q	LYS131
Q	LYS166
Q	LYS277

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
R	SER142
O	SER306

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
R	TYR172
O	LYS312

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
R	THR176
O	LYS326

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
R	SER200
O	SER347

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
R	SER244
O	SER387

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
R	SER280
O	THR548

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
R	LYS10
O	SER813

---

site_id	SWS_FT_FI12
Number of Residues	5
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
N	LYS564
R	LYS108
R	LYS178
R	LYS196
R	LYS281
O	LYS568
O	LYS592
O	LYS787

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
R	LYS99
R	LYS107
O	LYS848

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
N	LYS566
N	LYS704
O	LYS566
O	LYS704

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315

Chain	Residue	Details
L	ARG1276

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
L	SER1604

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
L	LYS1612
L	LYS1905

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
L	SER1751

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
L	THR1888

---