6LSD
Crystal Structure of YEATS domain of human YEATS2 in complex with H3K27bz peptide
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | LYS233 |
| A | ARG280 |
| A | HOH518 |
| B | LYS208 |
| B | ARG331 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | ARG203 |
| A | PHE205 |
| A | LYS207 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | SER241 |
| A | GLU244 |
| A | PRO245 |
| A | SER246 |
| A | GLY240 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| A | ARG279 |
| A | HOH509 |
| B | PRO245 |
| B | SER246 |
| B | HIS249 |
| B | HOH503 |
| B | HOH523 |
| B | HOH559 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | ARG203 |
| B | LYS208 |
| B | THR209 |
| B | HOH516 |
| B | HOH528 |
| B | HOH555 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | ARG203 |
| B | PHE205 |
| B | LYS207 |
| B | HOH543 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| B | LYS299 |
| B | ARG300 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 405 |
| Chain | Residue |
| B | LYS233 |
| B | GLN317 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 101 |
| Chain | Residue |
| C | ACE23 |
| C | ALA24 |
| C | ARG26 |
| C | HOH201 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 101 |
| Chain | Residue |
| D | ACE23 |
| D | ALA24 |
| D | ARG26 |
| D | HOH201 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide ACE C 23 and ALA C 24 |
| Chain | Residue |
| A | THR323 |
| A | VAL324 |
| A | VAL325 |
| C | ALA25 |
| C | SO4101 |
| site_id | AD3 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide ARG C 26 and ESU C 27 |
| Chain | Residue |
| A | SER230 |
| A | HIS259 |
| A | SER261 |
| A | TYR262 |
| A | GLY281 |
| A | TRP282 |
| A | GLY283 |
| A | GLU284 |
| A | PHE285 |
| A | ILE304 |
| A | ALA321 |
| A | GLU322 |
| A | HOH533 |
| C | ALA25 |
| C | SER28 |
| C | SO4101 |
| C | HOH203 |
| C | HOH205 |
| site_id | AD4 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide ESU C 27 and SER C 28 |
| Chain | Residue |
| A | SER230 |
| A | HIS259 |
| A | SER261 |
| A | TYR262 |
| A | GLY281 |
| A | TRP282 |
| A | GLY283 |
| A | GLU284 |
| A | GLY320 |
| A | ALA321 |
| A | GLU322 |
| A | HOH533 |
| A | HOH538 |
| C | ARG26 |
| C | ALA29 |
| C | PRO30 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide ACE D 23 and ALA D 24 |
| Chain | Residue |
| B | THR323 |
| B | VAL324 |
| B | VAL325 |
| D | ALA25 |
| D | ARG26 |
| D | SO4101 |
| site_id | AD6 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide ARG D 26 and ESU D 27 |
| Chain | Residue |
| B | GLU322 |
| B | HOH532 |
| D | ALA24 |
| D | ALA25 |
| D | SER28 |
| D | SO4101 |
| D | HOH204 |
| D | HOH207 |
| B | SER230 |
| B | HIS259 |
| B | SER261 |
| B | TYR262 |
| B | GLY281 |
| B | TRP282 |
| B | GLY283 |
| B | GLU284 |
| B | PHE285 |
| B | ILE304 |
| B | ALA321 |
| site_id | AD7 |
| Number of Residues | 17 |
| Details | binding site for Di-peptide ESU D 27 and SER D 28 |
| Chain | Residue |
| B | SER230 |
| B | HIS259 |
| B | SER261 |
| B | TYR262 |
| B | GLY281 |
| B | TRP282 |
| B | GLY283 |
| B | GLU284 |
| B | GLY320 |
| B | ALA321 |
| B | GLU322 |
| B | HOH532 |
| B | HOH539 |
| D | ARG26 |
| D | ALA29 |
| D | PRO30 |
| D | HOH203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Region: {"description":"Histone H3K27cr binding","evidences":[{"source":"PubMed","id":"27103431","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IQL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
