6LR0

structure of human bile salt exporter ABCB11

Functional Information from GO Data

Chain	GOid	namespace	contents
U	0000139	cellular_component	Golgi membrane
U	0005515	molecular_function	protein binding
U	0005524	molecular_function	ATP binding
U	0005768	cellular_component	endosome
U	0005886	cellular_component	plasma membrane
U	0006631	biological_process	fatty acid metabolic process
U	0006699	biological_process	bile acid biosynthetic process
U	0006805	biological_process	xenobiotic metabolic process
U	0006855	biological_process	xenobiotic transmembrane transport
U	0006869	biological_process	lipid transport
U	0006979	biological_process	response to oxidative stress
U	0008206	biological_process	bile acid metabolic process
U	0008559	molecular_function	ABC-type xenobiotic transporter activity
U	0009410	biological_process	response to xenobiotic stimulus
U	0009986	cellular_component	cell surface
U	0014070	biological_process	response to organic cyclic compound
U	0015125	molecular_function	bile acid transmembrane transporter activity
U	0015126	molecular_function	canalicular bile acid transmembrane transporter activity
U	0015144	molecular_function	carbohydrate transmembrane transporter activity
U	0015432	molecular_function	ABC-type bile acid transporter activity
U	0015721	biological_process	bile acid and bile salt transport
U	0015722	biological_process	canalicular bile acid transport
U	0016020	cellular_component	membrane
U	0016323	cellular_component	basolateral plasma membrane
U	0016324	cellular_component	apical plasma membrane
U	0016567	biological_process	protein ubiquitination
U	0016887	molecular_function	ATP hydrolysis activity
U	0031998	biological_process	regulation of fatty acid beta-oxidation
U	0034219	biological_process	carbohydrate transmembrane transport
U	0038183	biological_process	bile acid signaling pathway
U	0042632	biological_process	cholesterol homeostasis
U	0043627	biological_process	response to estrogen
U	0045177	cellular_component	apical part of cell
U	0045471	biological_process	response to ethanol
U	0046581	cellular_component	intercellular canaliculus
U	0046618	biological_process	xenobiotic export from cell
U	0046691	cellular_component	intracellular canaliculus
U	0055037	cellular_component	recycling endosome
U	0055038	cellular_component	recycling endosome membrane
U	0055085	biological_process	transmembrane transport
U	0055088	biological_process	lipid homeostasis
U	0055091	biological_process	phospholipid homeostasis
U	0070062	cellular_component	extracellular exosome
U	0071466	biological_process	cellular response to xenobiotic stimulus
U	0120188	biological_process	regulation of bile acid secretion
U	0120189	biological_process	positive regulation of bile acid secretion
U	0140359	molecular_function	ABC-type transporter activity
U	1904251	biological_process	regulation of bile acid metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. MSGGQKQRVAIARAL

Chain	Residue	Details
U	MET559-LEU573

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	952
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
U	MET1-MET62
U	ARG169-ASP215
U	SER262-GLY319
U	ASN375-MET755
U	GLN816-GLN869
U	ALA912-ASN979
U	ARG1033-SER1321

---

site_id	SWS_FT_FI2
Number of Residues	240
Details	TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
U	PHE63-PHE83
U	ILE891-LEU911
U	ILE980-TYR1000
U	LEU1012-GLY1032
U	ILE148-ALA168
U	GLN216-PHE236
U	LEU241-LEU261
U	ILE320-ALA340
U	TYR354-GLY374
U	LEU756-PHE776
U	ILE795-LEU815
U	GLY870-MET890

---

site_id	SWS_FT_FI3
Number of Residues	105
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
U	GLY84-GLY147
U	ARG237-LYS240
U	PHE341-GLU353
U	SER777-GLN794
U	ARG1001-GLY1011

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434

Chain	Residue	Details
U	GLY455
U	GLY1113

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
U	THR586

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site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
U	SER587
U	SER704
U	SER1214

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9QY30

Chain	Residue	Details
U	SER690

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O70127

Chain	Residue	Details
U	SER701
U	SER1321

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17082223

Chain	Residue	Details
U	ASN109
U	ASN116
U	ASN122
U	ASN125

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