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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6LQI

Cryo-EM structure of the mouse Piezo1 isoform Piezo1.1

Functional Information from GO Data
ChainGOidnamespacecontents
A0005261molecular_functionmonoatomic cation channel activity
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006812biological_processmonoatomic cation transport
A0008381molecular_functionmechanosensitive monoatomic ion channel activity
A0010831biological_processpositive regulation of myotube differentiation
A0016020cellular_componentmembrane
A0031258cellular_componentlamellipodium membrane
A0032420cellular_componentstereocilium
A0032437cellular_componentcuticular plate
A0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
A0033625biological_processpositive regulation of integrin activation
A0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
A0034220biological_processmonoatomic ion transmembrane transport
A0042391biological_processregulation of membrane potential
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0050982biological_processdetection of mechanical stimulus
A0071260biological_processcellular response to mechanical stimulus
A0098655biological_processmonoatomic cation transmembrane transport
A0140135molecular_functionmechanosensitive monoatomic cation channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005515molecular_functionprotein binding
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006812biological_processmonoatomic cation transport
B0008381molecular_functionmechanosensitive monoatomic ion channel activity
B0010831biological_processpositive regulation of myotube differentiation
B0016020cellular_componentmembrane
B0031258cellular_componentlamellipodium membrane
B0032420cellular_componentstereocilium
B0032437cellular_componentcuticular plate
B0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
B0033625biological_processpositive regulation of integrin activation
B0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
B0034220biological_processmonoatomic ion transmembrane transport
B0042391biological_processregulation of membrane potential
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0050982biological_processdetection of mechanical stimulus
B0071260biological_processcellular response to mechanical stimulus
B0098655biological_processmonoatomic cation transmembrane transport
B0140135molecular_functionmechanosensitive monoatomic cation channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005515molecular_functionprotein binding
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006812biological_processmonoatomic cation transport
C0008381molecular_functionmechanosensitive monoatomic ion channel activity
C0010831biological_processpositive regulation of myotube differentiation
C0016020cellular_componentmembrane
C0031258cellular_componentlamellipodium membrane
C0032420cellular_componentstereocilium
C0032437cellular_componentcuticular plate
C0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
C0033625biological_processpositive regulation of integrin activation
C0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
C0034220biological_processmonoatomic ion transmembrane transport
C0042391biological_processregulation of membrane potential
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0050982biological_processdetection of mechanical stimulus
C0071260biological_processcellular response to mechanical stimulus
C0098655biological_processmonoatomic cation transmembrane transport
C0140135molecular_functionmechanosensitive monoatomic cation channel activity
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YQCVAAH
ChainResidueDetails
ATYR1656-HIS1662
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues3
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=14","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues27
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=16","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues33
DetailsTransmembrane: {"description":"Helical; Name=17","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues30
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues39
DetailsTransmembrane: {"description":"Helical; Name=18","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues672
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=19","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues81
DetailsTransmembrane: {"description":"Helical; Name=20","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues45
DetailsTransmembrane: {"description":"Helical; Name=21","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues45
DetailsTransmembrane: {"description":"Helical; Name=22","evidences":[{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues45
DetailsTransmembrane: {"description":"Helical; Name=23","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues63
DetailsTransmembrane: {"description":"Helical; Name=24","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues78
DetailsTransmembrane: {"description":"Helical; Name=25","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Name=26","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=28","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues129
DetailsTransmembrane: {"description":"Helical; Name=29","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues45
DetailsTransmembrane: {"description":"Helical; Name=30","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Name=31","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues63
DetailsTransmembrane: {"description":"Helical; Name=32","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues57
DetailsTransmembrane: {"description":"Helical; Name=33","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=34","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues45
DetailsTransmembrane: {"description":"Helical; Name=36","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=37","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=38","evidences":[{"source":"PubMed","id":"35388220","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37590348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WLT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8IMZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues93
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19144319","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

240971

PDB entries from 2025-08-27

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