6LQ8
Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria smegmatis in complex with C22CoA
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004466 | molecular_function | long-chain fatty acyl-CoA dehydrogenase activity |
A | 0006631 | biological_process | fatty acid metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
A | 0016937 | molecular_function | short-chain fatty acyl-CoA dehydrogenase activity |
A | 0070991 | molecular_function | medium-chain fatty acyl-CoA dehydrogenase activity |
B | 0004466 | molecular_function | long-chain fatty acyl-CoA dehydrogenase activity |
B | 0006631 | biological_process | fatty acid metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
B | 0016937 | molecular_function | short-chain fatty acyl-CoA dehydrogenase activity |
B | 0070991 | molecular_function | medium-chain fatty acyl-CoA dehydrogenase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 33 |
Details | binding site for residue FAD A 701 |
Chain | Residue |
A | MET162 |
A | LEU445 |
A | TYR446 |
A | ALA447 |
A | THR449 |
A | ALA451 |
A | EO3702 |
A | COA703 |
A | HOH874 |
A | HOH973 |
A | HOH987 |
A | LEU164 |
A | HOH988 |
A | HOH990 |
A | HOH1049 |
B | ARG326 |
B | GLN328 |
B | ILE345 |
B | HIS348 |
B | GLN420 |
B | THR421 |
B | GLY423 |
A | THR165 |
B | GLY424 |
B | HOH850 |
B | HOH897 |
B | HOH919 |
A | GLY170 |
A | SER171 |
A | PHE196 |
A | ILE197 |
A | THR198 |
A | ILE442 |
site_id | AC2 |
Number of Residues | 32 |
Details | binding site for residue FAD B 701 |
Chain | Residue |
A | ARG326 |
A | GLN328 |
A | ILE345 |
A | HIS348 |
A | GLN420 |
A | THR421 |
A | GLY423 |
A | GLY424 |
A | HOH836 |
A | HOH857 |
A | HOH1023 |
B | MET162 |
B | LEU164 |
B | THR165 |
B | GLY170 |
B | SER171 |
B | PHE196 |
B | ILE197 |
B | THR198 |
B | ILE442 |
B | LEU445 |
B | TYR446 |
B | ALA447 |
B | THR449 |
B | ALA451 |
B | EO3702 |
B | COA703 |
B | HOH996 |
B | HOH1050 |
B | HOH1068 |
B | HOH1080 |
B | HOH1196 |
site_id | AC3 |
Number of Residues | 42 |
Details | binding site for residues EO3 A 702 and COA A 703 |
Chain | Residue |
A | HOH963 |
A | HOH975 |
A | HOH1054 |
A | HOH1063 |
A | HOH1070 |
A | HOH1080 |
A | HOH1203 |
B | LYS338 |
A | VAL95 |
A | GLY96 |
A | LEU97 |
A | GLN111 |
A | MET130 |
A | GLY133 |
A | MET134 |
A | GLU136 |
A | ILE137 |
A | MET162 |
A | SER171 |
A | VAL173 |
A | THR198 |
A | THR224 |
A | LYS225 |
A | ILE290 |
A | PHE294 |
A | GLU298 |
A | GLN299 |
A | ALA300 |
A | ARG301 |
A | TYR446 |
A | ALA447 |
A | GLY448 |
A | ASP456 |
A | ARG460 |
A | LYS461 |
A | ARG464 |
A | FAD701 |
A | HOH834 |
A | HOH848 |
A | HOH886 |
A | HOH904 |
A | HOH910 |
site_id | AC4 |
Number of Residues | 43 |
Details | binding site for residues EO3 B 702 and COA B 703 |
Chain | Residue |
A | LYS338 |
A | HOH1176 |
B | ARG108 |
B | GLN111 |
B | TRP112 |
B | MET130 |
B | GLY133 |
B | MET134 |
B | ALA160 |
B | MET162 |
B | SER171 |
B | VAL173 |
B | THR198 |
B | THR224 |
B | LYS225 |
B | ILE290 |
B | PHE294 |
B | GLU298 |
B | GLN299 |
B | ARG301 |
B | GLN376 |
B | TYR446 |
B | ALA447 |
B | GLY448 |
B | ILE452 |
B | ASP456 |
B | ARG460 |
B | LYS461 |
B | FAD701 |
B | HOH824 |
B | HOH849 |
B | HOH876 |
B | HOH916 |
B | HOH920 |
B | HOH923 |
B | HOH981 |
B | HOH1008 |
B | HOH1027 |
B | HOH1059 |
B | HOH1112 |
B | HOH1139 |
B | HOH1236 |
B | HOH1266 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:32601219 |
Chain | Residue | Details |
A | ALA447 | |
B | ALA447 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000269|PubMed:32601219 |
Chain | Residue | Details |
A | MET162 | |
A | THR449 | |
A | ASP456 | |
A | ARG460 | |
B | MET162 | |
B | SER171 | |
B | THR198 | |
B | THR224 | |
B | ARG301 | |
B | ARG326 | |
B | LYS338 | |
A | SER171 | |
B | GLN420 | |
B | ALA447 | |
B | THR449 | |
B | ASP456 | |
B | ARG460 | |
A | THR198 | |
A | THR224 | |
A | ARG301 | |
A | ARG326 | |
A | LYS338 | |
A | GLN420 | |
A | ALA447 |