6LPK

A2AR crystallized in EROCOC17+4, LCP-SFX at 293 K

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001609	molecular_function	G protein-coupled adenosine receptor activity
A	0001973	biological_process	G protein-coupled adenosine receptor signaling pathway
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005506	molecular_function	iron ion binding
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue ZMA A 2401

Chain	Residue
A	LEU85
A	ILE274
A	HOH2515
A	HOH2517
A	HOH2556
A	HOH2566
A	PHE168
A	GLU169
A	MET177
A	TRP246
A	LEU249
A	HIS250
A	ASN253
A	MET270

---

site_id	AC2
Number of Residues	5
Details	binding site for residue NA A 2402

Chain	Residue
A	ASP52
A	SER91
A	HOH2522
A	HOH2546
A	HOH2579

---

site_id	AC3
Number of Residues	7
Details	binding site for residue CLR A 2403

Chain	Residue
A	ALA72
A	ALA73
A	GLY76
A	ILE80
A	TRD2422
A	ER02423
A	MYS2426

---

site_id	AC4
Number of Residues	5
Details	binding site for residue CLR A 2404

Chain	Residue
A	PRO248
A	CYS262
A	SER263
A	LEU269
A	HOH2550

---

site_id	AC5
Number of Residues	3
Details	binding site for residue CLR A 2405

Chain	Residue
A	MYS2409
A	ER02423
A	HOH2505

---

site_id	AC6
Number of Residues	1
Details	binding site for residue HEX A 2408

Chain	Residue
A	8K62410

---

site_id	AC7
Number of Residues	3
Details	binding site for residue MYS A 2409

Chain	Residue
A	CLR2405
A	ER02423
A	HOH2550

---

site_id	AC8
Number of Residues	4
Details	binding site for residue 8K6 A 2410

Chain	Residue
A	SER6
A	SER7
A	THR11
A	HEX2408

---

site_id	AC9
Number of Residues	1
Details	binding site for residue D10 A 2411

Chain	Residue
A	ILE124

---

site_id	AD1
Number of Residues	3
Details	binding site for residue MYS A 2414

Chain	Residue
A	TYR290
A	ER02416
A	8K62419

---

site_id	AD2
Number of Residues	2
Details	binding site for residue UND A 2415

Chain	Residue
A	SER7
A	TRP29

---

site_id	AD3
Number of Residues	8
Details	binding site for residue ER0 A 2416

Chain	Residue
A	PRO2
A	GLY5
A	SER6
A	TRP268
A	TYR271
A	LEU272
A	THR279
A	MYS2414

---

site_id	AD4
Number of Residues	2
Details	binding site for residue MYS A 2417

Chain	Residue
A	PHE180
A	MYS2424

---

site_id	AD5
Number of Residues	1
Details	binding site for residue 8K6 A 2419

Chain	Residue
A	MYS2414

---

site_id	AD6
Number of Residues	1
Details	binding site for residue OCT A 2421

Chain	Residue
A	PHE257

---

site_id	AD7
Number of Residues	1
Details	binding site for residue TRD A 2422

Chain	Residue
A	CLR2403

---

site_id	AD8
Number of Residues	9
Details	binding site for residue ER0 A 2423

Chain	Residue
A	GLY56
A	VAL57
A	PHE70
A	CYS71
A	GLN163
A	CLR2403
A	CLR2405
A	MYS2409
A	HOH2529

---

site_id	AD9
Number of Residues	3
Details	binding site for residue MYS A 2424

Chain	Residue
A	LEU141
A	TYR179
A	MYS2417

---

site_id	AE1
Number of Residues	1
Details	binding site for residue TRD A 2425

Chain	Residue
A	TRD2427

---

site_id	AE2
Number of Residues	2
Details	binding site for residue MYS A 2426

Chain	Residue
A	PHE258
A	CLR2403

---

site_id	AE3
Number of Residues	2
Details	binding site for residue TRD A 2427

Chain	Residue
A	TYR43
A	TRD2425

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIfSLLAIAIDRYIaI

Chain	Residue	Details
A	SER90-ILE106

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"18832607","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	46
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18832607","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21593763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2YDO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---