Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue HEC A 301 |
| Chain | Residue |
| A | GLY59 |
| A | HIS98 |
| A | ILE101 |
| A | ILE102 |
| A | LYS107 |
| A | PHE110 |
| A | TRP123 |
| A | HEC304 |
| A | GLY60 |
| A | PHE61 |
| A | LEU65 |
| A | HIS66 |
| A | MET71 |
| A | THR93 |
| A | CYS94 |
| A | CYS97 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue HEC A 302 |
| Chain | Residue |
| A | ARG48 |
| A | PHE132 |
| A | VAL133 |
| A | LEU166 |
| A | PHE167 |
| A | MET168 |
| A | CYS171 |
| A | HIS175 |
| A | ASN220 |
| A | CYS221 |
| A | CYS224 |
| A | HIS225 |
| B | ALA839 |
| B | ASN854 |
| B | ARG855 |
| C | TRP150 |
| C | MET160 |
| D | TYR97 |
| D | LEU99 |
| E | HIS34 |
| E | TYR38 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | binding site for residue HEC A 303 |
| Chain | Residue |
| A | HIS77 |
| A | HIS85 |
| A | ALA86 |
| A | ASN87 |
| A | ILE88 |
| A | LYS125 |
| A | HIS127 |
| A | LEU129 |
| A | PHE135 |
| A | HIS137 |
| A | HIS140 |
| A | VAL141 |
| A | VAL145 |
| A | GLY146 |
| A | CYS147 |
| A | CYS150 |
| A | HIS151 |
| A | PHE189 |
| A | HEC304 |
| B | HEC1101 |
| B | ILE89 |
| E | GLN46 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | binding site for residue HEC A 304 |
| Chain | Residue |
| A | GLN56 |
| A | PHE61 |
| A | HIS63 |
| A | MET71 |
| A | CYS73 |
| A | CYS76 |
| A | HIS77 |
| A | TRP123 |
| A | ASN124 |
| A | LYS125 |
| A | VAL126 |
| A | HIS127 |
| A | CYS147 |
| A | HIS151 |
| A | ILE154 |
| A | MET191 |
| A | HEC301 |
| A | HEC303 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue HEC B 1101 |
| Chain | Residue |
| A | VAL133 |
| A | PHE135 |
| A | ILE139 |
| A | HIS140 |
| A | LYS143 |
| A | VAL145 |
| A | TRP170 |
| A | CYS171 |
| A | CYS174 |
| A | HIS175 |
| A | TYR181 |
| A | ARG213 |
| A | LEU218 |
| A | ILE223 |
| A | CYS224 |
| A | HEC303 |
| B | ARG929 |
| B | ILE930 |
| B | ARG933 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue EL6 B 1102 |
| Chain | Residue |
| B | CYS78 |
| C | PHE69 |
| C | TRP146 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue SF4 B 1103 |
| Chain | Residue |
| B | CYS769 |
| B | ASN770 |
| B | SER771 |
| B | CYS772 |
| B | ASN773 |
| B | CYS775 |
| B | ILE804 |
| B | CYS952 |
| B | THR954 |
| B | ILE957 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue SF4 B 1104 |
| Chain | Residue |
| B | CYS779 |
| B | ASN783 |
| B | TRP801 |
| B | CYS918 |
| B | PHE920 |
| B | CYS921 |
| B | THR946 |
| B | CYS948 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residue SF4 B 1105 |
| Chain | Residue |
| B | CYS824 |
| B | GLN825 |
| B | GLN826 |
| B | CYS827 |
| B | PRO831 |
| B | CYS832 |
| B | ASN849 |
| B | CYS866 |
| B | TYR868 |
| B | VAL870 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue F3S B 1106 |
| Chain | Residue |
| B | VAL835 |
| B | CYS836 |
| B | VAL838 |
| B | CYS856 |
| B | VAL857 |
| B | GLY858 |
| B | THR859 |
| B | CYS862 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue EL6 E 201 |
| Chain | Residue |
| A | PHE41 |
| C | SER176 |
| E | CYS33 |
| site_id | AD3 |
| Number of Residues | 14 |
| Details | binding site for residue HEC E 202 |
| Chain | Residue |
| E | TYR112 |
| E | CYS113 |
| E | CYS116 |
| E | HIS117 |
| E | PRO133 |
| E | PRO136 |
| E | ARG142 |
| E | VAL154 |
| E | ARG159 |
| E | ARG160 |
| E | THR161 |
| E | MET162 |
| E | TYR165 |
| E | ILE182 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue ACE E 32 |
| Chain | Residue |
| B | ALA81 |
| B | LEU82 |
| E | CYS33 |
| E | HIS34 |
| E | LEU35 |
| E | TYR38 |
