6LO8

Cryo-EM structure of the TIM22 complex from yeast

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005198	molecular_function	structural molecule activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0008320	molecular_function	protein transmembrane transporter activity
A	0015031	biological_process	protein transport
A	0030943	molecular_function	mitochondrion targeting sequence binding
A	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
A	0045039	biological_process	protein insertion into mitochondrial inner membrane
A	0071806	biological_process	protein transmembrane transport
B	0001727	molecular_function	lipid kinase activity
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0006665	biological_process	sphingolipid metabolic process
B	0008320	molecular_function	protein transmembrane transporter activity
B	0015031	biological_process	protein transport
B	0016020	cellular_component	membrane
B	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0045039	biological_process	protein insertion into mitochondrial inner membrane
B	0071806	biological_process	protein transmembrane transport
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006099	biological_process	tricarboxylic acid cycle
C	0006121	biological_process	mitochondrial electron transport, succinate to ubiquinone
C	0008177	molecular_function	succinate dehydrogenase (quinone) activity
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0031966	cellular_component	mitochondrial membrane
C	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
C	0045039	biological_process	protein insertion into mitochondrial inner membrane
C	0045273	cellular_component	respiratory chain complex II (succinate dehydrogenase)
C	0045333	biological_process	cellular respiration
C	0046872	molecular_function	metal ion binding
C	0048038	molecular_function	quinone binding
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005740	cellular_component	mitochondrial envelope
D	0005743	cellular_component	mitochondrial inner membrane
D	0006915	biological_process	apoptotic process
D	0006970	biological_process	response to osmotic stress
D	0008320	molecular_function	protein transmembrane transporter activity
D	0015031	biological_process	protein transport
D	0016020	cellular_component	membrane
D	0031966	cellular_component	mitochondrial membrane
D	0034599	biological_process	cellular response to oxidative stress
D	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
D	0045039	biological_process	protein insertion into mitochondrial inner membrane
D	0046685	biological_process	response to arsenic-containing substance
D	0071806	biological_process	protein transmembrane transport
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005758	cellular_component	mitochondrial intermembrane space
E	0008270	molecular_function	zinc ion binding
E	0015031	biological_process	protein transport
E	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
E	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
E	0045039	biological_process	protein insertion into mitochondrial inner membrane
E	0046872	molecular_function	metal ion binding
E	0051082	molecular_function	unfolded protein binding
E	0140318	molecular_function	protein transporter activity
F	0005515	molecular_function	protein binding
F	0005543	molecular_function	phospholipid binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005758	cellular_component	mitochondrial intermembrane space
F	0008270	molecular_function	zinc ion binding
F	0008320	molecular_function	protein transmembrane transporter activity
F	0015031	biological_process	protein transport
F	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
F	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
F	0045039	biological_process	protein insertion into mitochondrial inner membrane
F	0046872	molecular_function	metal ion binding
F	0071806	biological_process	protein transmembrane transport
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005758	cellular_component	mitochondrial intermembrane space
G	0008270	molecular_function	zinc ion binding
G	0015031	biological_process	protein transport
G	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
G	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
G	0045039	biological_process	protein insertion into mitochondrial inner membrane
G	0046872	molecular_function	metal ion binding
G	0051082	molecular_function	unfolded protein binding
G	0140318	molecular_function	protein transporter activity
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005758	cellular_component	mitochondrial intermembrane space
H	0008270	molecular_function	zinc ion binding
H	0015031	biological_process	protein transport
H	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
H	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
H	0045039	biological_process	protein insertion into mitochondrial inner membrane
H	0046872	molecular_function	metal ion binding
H	0051082	molecular_function	unfolded protein binding
H	0140318	molecular_function	protein transporter activity
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005758	cellular_component	mitochondrial intermembrane space
I	0008270	molecular_function	zinc ion binding
I	0015031	biological_process	protein transport
I	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
I	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
I	0045039	biological_process	protein insertion into mitochondrial inner membrane
I	0046872	molecular_function	metal ion binding
I	0051082	molecular_function	unfolded protein binding
I	0140318	molecular_function	protein transporter activity
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005758	cellular_component	mitochondrial intermembrane space
J	0008270	molecular_function	zinc ion binding
J	0015031	biological_process	protein transport
J	0042719	cellular_component	mitochondrial intermembrane space protein transporter complex
J	0042721	cellular_component	TIM22 mitochondrial import inner membrane insertion complex
J	0045039	biological_process	protein insertion into mitochondrial inner membrane
J	0046872	molecular_function	metal ion binding
J	0051082	molecular_function	unfolded protein binding
J	0140318	molecular_function	protein transporter activity

Functional Information from PROSITE/UniProt

site_id	PS01000
Number of Residues	25
Details	SDH_CYT_1 Succinate dehydrogenase cytochrome b subunit signature 1. RPIsphLtiyqpqLtwylSslHRiS

Chain	Residue	Details
C	ARG75-SER99

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site_id	PS01001
Number of Residues	14
Details	SDH_CYT_2 Succinate dehydrogenase cytochrome b subunit signature 2. HyggAIRHLiWDtA

Chain	Residue	Details
C	HIS156-ALA169

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
F	SER2
G	MET1
I	MET1

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site_id	SWS_FT_FI2
Number of Residues	60
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
D	LEU89-LEU109
D	LEU114-ILE134
D	LEU145-GLU165

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site_id	SWS_FT_FI3
Number of Residues	29
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000255

Chain	Residue	Details
D	LEU110-SER113
D	THR166-ASN192

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site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
C	SER93
C	ARG97

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site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000250

Chain	Residue	Details
C	HIS156

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