6LNI

Cryo-EM structure of amyloid fibril formed by full-length human prion protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001540	molecular_function	amyloid-beta binding
A	0002020	molecular_function	protease binding
A	0005507	molecular_function	copper ion binding
A	0005515	molecular_function	protein binding
A	0005521	molecular_function	lamin binding
A	0005539	molecular_function	glycosaminoglycan binding
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006878	biological_process	intracellular copper ion homeostasis
A	0006979	biological_process	response to oxidative stress
A	0007611	biological_process	learning or memory
A	0007616	biological_process	long-term memory
A	0008017	molecular_function	microtubule binding
A	0009897	cellular_component	external side of plasma membrane
A	0009986	cellular_component	cell surface
A	0010955	biological_process	negative regulation of protein processing
A	0014069	cellular_component	postsynaptic density
A	0015631	molecular_function	tubulin binding
A	0016020	cellular_component	membrane
A	0016234	cellular_component	inclusion body
A	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
A	0019898	cellular_component	extrinsic component of membrane
A	0030425	cellular_component	dendrite
A	0031648	biological_process	protein destabilization
A	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
A	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
A	0032689	biological_process	negative regulation of type II interferon production
A	0032700	biological_process	negative regulation of interleukin-17 production
A	0032703	biological_process	negative regulation of interleukin-2 production
A	0035556	biological_process	intracellular signal transduction
A	0038023	molecular_function	signaling receptor activity
A	0042802	molecular_function	identical protein binding
A	0043008	molecular_function	ATP-dependent protein binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0043195	cellular_component	terminal bouton
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0044325	molecular_function	transmembrane transporter binding
A	0044877	molecular_function	protein-containing complex binding
A	0045121	cellular_component	membrane raft
A	0046007	biological_process	negative regulation of activated T cell proliferation
A	0046686	biological_process	response to cadmium ion
A	0046688	biological_process	response to copper ion
A	0046872	molecular_function	metal ion binding
A	0050850	biological_process	positive regulation of calcium-mediated signaling
A	0050860	biological_process	negative regulation of T cell receptor signaling pathway
A	0051087	molecular_function	protein-folding chaperone binding
A	0051260	biological_process	protein homooligomerization
A	0051726	biological_process	regulation of cell cycle
A	0060090	molecular_function	molecular adaptor activity
A	0070062	cellular_component	extracellular exosome
A	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
A	0071280	biological_process	cellular response to copper ion
A	0090314	biological_process	positive regulation of protein targeting to membrane
A	0097062	biological_process	dendritic spine maintenance
A	0098552	cellular_component	side of membrane
A	0098794	cellular_component	postsynapse
A	0140677	molecular_function	molecular function activator activity
A	0140693	molecular_function	molecular condensate scaffold activity
A	1900272	biological_process	negative regulation of long-term synaptic potentiation
A	1900449	biological_process	regulation of glutamate receptor signaling pathway
A	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
A	1902430	biological_process	negative regulation of amyloid-beta formation
A	1902951	biological_process	negative regulation of dendritic spine maintenance
A	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
A	1903078	biological_process	positive regulation of protein localization to plasma membrane
A	1903135	molecular_function	cupric ion binding
A	1903136	molecular_function	cuprous ion binding
A	1904645	biological_process	response to amyloid-beta
A	1904646	biological_process	cellular response to amyloid-beta
A	1905664	biological_process	regulation of calcium ion import across plasma membrane
A	1990535	biological_process	neuron projection maintenance
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0001540	molecular_function	amyloid-beta binding
B	0002020	molecular_function	protease binding
B	0005507	molecular_function	copper ion binding
B	0005515	molecular_function	protein binding
B	0005521	molecular_function	lamin binding
B	0005539	molecular_function	glycosaminoglycan binding
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006878	biological_process	intracellular copper ion homeostasis
B	0006979	biological_process	response to oxidative stress
B	0007611	biological_process	learning or memory
B	0007616	biological_process	long-term memory
B	0008017	molecular_function	microtubule binding
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010955	biological_process	negative regulation of protein processing
B	0014069	cellular_component	postsynaptic density
B	0015631	molecular_function	tubulin binding
B	0016020	cellular_component	membrane
B	0016234	cellular_component	inclusion body
B	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
B	0019898	cellular_component	extrinsic component of membrane
B	0030425	cellular_component	dendrite
B	0031648	biological_process	protein destabilization
B	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
B	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
B	0032689	biological_process	negative regulation of type II interferon production
B	0032700	biological_process	negative regulation of interleukin-17 production
B	0032703	biological_process	negative regulation of interleukin-2 production
B	0035556	biological_process	intracellular signal transduction
B	0038023	molecular_function	signaling receptor activity
B	0042802	molecular_function	identical protein binding
B	0043008	molecular_function	ATP-dependent protein binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0043195	cellular_component	terminal bouton
B	0043525	biological_process	positive regulation of neuron apoptotic process
B	0044325	molecular_function	transmembrane transporter binding
B	0044877	molecular_function	protein-containing complex binding
B	0045121	cellular_component	membrane raft
B	0046007	biological_process	negative regulation of activated T cell proliferation
B	0046686	biological_process	response to cadmium ion
B	0046688	biological_process	response to copper ion
B	0046872	molecular_function	metal ion binding
B	0050850	biological_process	positive regulation of calcium-mediated signaling
B	0050860	biological_process	negative regulation of T cell receptor signaling pathway
B	0051087	molecular_function	protein-folding chaperone binding
B	0051260	biological_process	protein homooligomerization
B	0051726	biological_process	regulation of cell cycle
B	0060090	molecular_function	molecular adaptor activity
B	0070062	cellular_component	extracellular exosome
B	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
B	0071280	biological_process	cellular response to copper ion
B	0090314	biological_process	positive regulation of protein targeting to membrane
B	0097062	biological_process	dendritic spine maintenance
B	0098552	cellular_component	side of membrane
B	0098794	cellular_component	postsynapse
B	0140677	molecular_function	molecular function activator activity
B	0140693	molecular_function	molecular condensate scaffold activity
B	1900272	biological_process	negative regulation of long-term synaptic potentiation
B	1900449	biological_process	regulation of glutamate receptor signaling pathway
B	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
B	1902430	biological_process	negative regulation of amyloid-beta formation
B	1902951	biological_process	negative regulation of dendritic spine maintenance
B	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
B	1903078	biological_process	positive regulation of protein localization to plasma membrane
B	1903135	molecular_function	cupric ion binding
B	1903136	molecular_function	cuprous ion binding
B	1904645	biological_process	response to amyloid-beta
B	1904646	biological_process	cellular response to amyloid-beta
B	1905664	biological_process	regulation of calcium ion import across plasma membrane
B	1990535	biological_process	neuron projection maintenance
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0001540	molecular_function	amyloid-beta binding
C	0002020	molecular_function	protease binding
C	0005507	molecular_function	copper ion binding
C	0005515	molecular_function	protein binding
C	0005521	molecular_function	lamin binding
C	0005539	molecular_function	glycosaminoglycan binding
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006878	biological_process	intracellular copper ion homeostasis
C	0006979	biological_process	response to oxidative stress
C	0007611	biological_process	learning or memory
C	0007616	biological_process	long-term memory
C	0008017	molecular_function	microtubule binding
C	0009897	cellular_component	external side of plasma membrane
C	0009986	cellular_component	cell surface
C	0010955	biological_process	negative regulation of protein processing
C	0014069	cellular_component	postsynaptic density
C	0015631	molecular_function	tubulin binding
C	0016020	cellular_component	membrane
C	0016234	cellular_component	inclusion body
C	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
C	0019898	cellular_component	extrinsic component of membrane
C	0030425	cellular_component	dendrite
C	0031648	biological_process	protein destabilization
C	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
C	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
C	0032689	biological_process	negative regulation of type II interferon production
C	0032700	biological_process	negative regulation of interleukin-17 production
C	0032703	biological_process	negative regulation of interleukin-2 production
C	0035556	biological_process	intracellular signal transduction
C	0038023	molecular_function	signaling receptor activity
C	0042802	molecular_function	identical protein binding
C	0043008	molecular_function	ATP-dependent protein binding
C	0043066	biological_process	negative regulation of apoptotic process
C	0043195	cellular_component	terminal bouton
C	0043525	biological_process	positive regulation of neuron apoptotic process
C	0044325	molecular_function	transmembrane transporter binding
C	0044877	molecular_function	protein-containing complex binding
C	0045121	cellular_component	membrane raft
C	0046007	biological_process	negative regulation of activated T cell proliferation
C	0046686	biological_process	response to cadmium ion
C	0046688	biological_process	response to copper ion
C	0046872	molecular_function	metal ion binding
C	0050850	biological_process	positive regulation of calcium-mediated signaling
C	0050860	biological_process	negative regulation of T cell receptor signaling pathway
C	0051087	molecular_function	protein-folding chaperone binding
C	0051260	biological_process	protein homooligomerization
C	0051726	biological_process	regulation of cell cycle
C	0060090	molecular_function	molecular adaptor activity
C	0070062	cellular_component	extracellular exosome
C	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
C	0071280	biological_process	cellular response to copper ion
C	0090314	biological_process	positive regulation of protein targeting to membrane
C	0097062	biological_process	dendritic spine maintenance
C	0098552	cellular_component	side of membrane
C	0098794	cellular_component	postsynapse
C	0140677	molecular_function	molecular function activator activity
C	0140693	molecular_function	molecular condensate scaffold activity
C	1900272	biological_process	negative regulation of long-term synaptic potentiation
C	1900449	biological_process	regulation of glutamate receptor signaling pathway
C	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
C	1902430	biological_process	negative regulation of amyloid-beta formation
C	1902951	biological_process	negative regulation of dendritic spine maintenance
C	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
C	1903078	biological_process	positive regulation of protein localization to plasma membrane
C	1903135	molecular_function	cupric ion binding
C	1903136	molecular_function	cuprous ion binding
C	1904645	biological_process	response to amyloid-beta
C	1904646	biological_process	cellular response to amyloid-beta
C	1905664	biological_process	regulation of calcium ion import across plasma membrane
C	1990535	biological_process	neuron projection maintenance
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0001540	molecular_function	amyloid-beta binding
D	0002020	molecular_function	protease binding
D	0005507	molecular_function	copper ion binding
D	0005515	molecular_function	protein binding
D	0005521	molecular_function	lamin binding
D	0005539	molecular_function	glycosaminoglycan binding
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006878	biological_process	intracellular copper ion homeostasis
D	0006979	biological_process	response to oxidative stress
D	0007611	biological_process	learning or memory
D	0007616	biological_process	long-term memory
D	0008017	molecular_function	microtubule binding
D	0009897	cellular_component	external side of plasma membrane
D	0009986	cellular_component	cell surface
D	0010955	biological_process	negative regulation of protein processing
D	0014069	cellular_component	postsynaptic density
D	0015631	molecular_function	tubulin binding
D	0016020	cellular_component	membrane
D	0016234	cellular_component	inclusion body
D	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
D	0019898	cellular_component	extrinsic component of membrane
D	0030425	cellular_component	dendrite
D	0031648	biological_process	protein destabilization
D	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
D	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
D	0032689	biological_process	negative regulation of type II interferon production
D	0032700	biological_process	negative regulation of interleukin-17 production
D	0032703	biological_process	negative regulation of interleukin-2 production
D	0035556	biological_process	intracellular signal transduction
D	0038023	molecular_function	signaling receptor activity
D	0042802	molecular_function	identical protein binding
D	0043008	molecular_function	ATP-dependent protein binding
D	0043066	biological_process	negative regulation of apoptotic process
D	0043195	cellular_component	terminal bouton
D	0043525	biological_process	positive regulation of neuron apoptotic process
D	0044325	molecular_function	transmembrane transporter binding
D	0044877	molecular_function	protein-containing complex binding
D	0045121	cellular_component	membrane raft
D	0046007	biological_process	negative regulation of activated T cell proliferation
D	0046686	biological_process	response to cadmium ion
D	0046688	biological_process	response to copper ion
D	0046872	molecular_function	metal ion binding
D	0050850	biological_process	positive regulation of calcium-mediated signaling
D	0050860	biological_process	negative regulation of T cell receptor signaling pathway
D	0051087	molecular_function	protein-folding chaperone binding
D	0051260	biological_process	protein homooligomerization
D	0051726	biological_process	regulation of cell cycle
D	0060090	molecular_function	molecular adaptor activity
D	0070062	cellular_component	extracellular exosome
D	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
D	0071280	biological_process	cellular response to copper ion
D	0090314	biological_process	positive regulation of protein targeting to membrane
D	0097062	biological_process	dendritic spine maintenance
D	0098552	cellular_component	side of membrane
D	0098794	cellular_component	postsynapse
D	0140677	molecular_function	molecular function activator activity
D	0140693	molecular_function	molecular condensate scaffold activity
D	1900272	biological_process	negative regulation of long-term synaptic potentiation
D	1900449	biological_process	regulation of glutamate receptor signaling pathway
D	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
D	1902430	biological_process	negative regulation of amyloid-beta formation
D	1902951	biological_process	negative regulation of dendritic spine maintenance
D	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
D	1903078	biological_process	positive regulation of protein localization to plasma membrane
D	1903135	molecular_function	cupric ion binding
D	1903136	molecular_function	cuprous ion binding
D	1904645	biological_process	response to amyloid-beta
D	1904646	biological_process	cellular response to amyloid-beta
D	1905664	biological_process	regulation of calcium ion import across plasma membrane
D	1990535	biological_process	neuron projection maintenance
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0001540	molecular_function	amyloid-beta binding
E	0002020	molecular_function	protease binding
E	0005507	molecular_function	copper ion binding
E	0005515	molecular_function	protein binding
E	0005521	molecular_function	lamin binding
E	0005539	molecular_function	glycosaminoglycan binding
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006878	biological_process	intracellular copper ion homeostasis
E	0006979	biological_process	response to oxidative stress
E	0007611	biological_process	learning or memory
E	0007616	biological_process	long-term memory
E	0008017	molecular_function	microtubule binding
E	0009897	cellular_component	external side of plasma membrane
E	0009986	cellular_component	cell surface
E	0010955	biological_process	negative regulation of protein processing
E	0014069	cellular_component	postsynaptic density
E	0015631	molecular_function	tubulin binding
E	0016020	cellular_component	membrane
E	0016234	cellular_component	inclusion body
E	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
E	0019898	cellular_component	extrinsic component of membrane
E	0030425	cellular_component	dendrite
E	0031648	biological_process	protein destabilization
E	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
E	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
E	0032689	biological_process	negative regulation of type II interferon production
E	0032700	biological_process	negative regulation of interleukin-17 production
E	0032703	biological_process	negative regulation of interleukin-2 production
E	0035556	biological_process	intracellular signal transduction
E	0038023	molecular_function	signaling receptor activity
E	0042802	molecular_function	identical protein binding
E	0043008	molecular_function	ATP-dependent protein binding
E	0043066	biological_process	negative regulation of apoptotic process
E	0043195	cellular_component	terminal bouton
E	0043525	biological_process	positive regulation of neuron apoptotic process
E	0044325	molecular_function	transmembrane transporter binding
E	0044877	molecular_function	protein-containing complex binding
E	0045121	cellular_component	membrane raft
E	0046007	biological_process	negative regulation of activated T cell proliferation
E	0046686	biological_process	response to cadmium ion
E	0046688	biological_process	response to copper ion
E	0046872	molecular_function	metal ion binding
E	0050850	biological_process	positive regulation of calcium-mediated signaling
E	0050860	biological_process	negative regulation of T cell receptor signaling pathway
E	0051087	molecular_function	protein-folding chaperone binding
E	0051260	biological_process	protein homooligomerization
E	0051726	biological_process	regulation of cell cycle
E	0060090	molecular_function	molecular adaptor activity
E	0070062	cellular_component	extracellular exosome
E	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
E	0071280	biological_process	cellular response to copper ion
E	0090314	biological_process	positive regulation of protein targeting to membrane
E	0097062	biological_process	dendritic spine maintenance
E	0098552	cellular_component	side of membrane
E	0098794	cellular_component	postsynapse
E	0140677	molecular_function	molecular function activator activity
E	0140693	molecular_function	molecular condensate scaffold activity
E	1900272	biological_process	negative regulation of long-term synaptic potentiation
E	1900449	biological_process	regulation of glutamate receptor signaling pathway
E	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
E	1902430	biological_process	negative regulation of amyloid-beta formation
E	1902951	biological_process	negative regulation of dendritic spine maintenance
E	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
E	1903078	biological_process	positive regulation of protein localization to plasma membrane
E	1903135	molecular_function	cupric ion binding
E	1903136	molecular_function	cuprous ion binding
E	1904645	biological_process	response to amyloid-beta
E	1904646	biological_process	cellular response to amyloid-beta
E	1905664	biological_process	regulation of calcium ion import across plasma membrane
E	1990535	biological_process	neuron projection maintenance
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0001540	molecular_function	amyloid-beta binding
F	0002020	molecular_function	protease binding
F	0005507	molecular_function	copper ion binding
F	0005515	molecular_function	protein binding
F	0005521	molecular_function	lamin binding
F	0005539	molecular_function	glycosaminoglycan binding
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005794	cellular_component	Golgi apparatus
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006878	biological_process	intracellular copper ion homeostasis
F	0006979	biological_process	response to oxidative stress
F	0007611	biological_process	learning or memory
F	0007616	biological_process	long-term memory
F	0008017	molecular_function	microtubule binding
F	0009897	cellular_component	external side of plasma membrane
F	0009986	cellular_component	cell surface
F	0010955	biological_process	negative regulation of protein processing
F	0014069	cellular_component	postsynaptic density
F	0015631	molecular_function	tubulin binding
F	0016020	cellular_component	membrane
F	0016234	cellular_component	inclusion body
F	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
F	0019898	cellular_component	extrinsic component of membrane
F	0030425	cellular_component	dendrite
F	0031648	biological_process	protein destabilization
F	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
F	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
F	0032689	biological_process	negative regulation of type II interferon production
F	0032700	biological_process	negative regulation of interleukin-17 production
F	0032703	biological_process	negative regulation of interleukin-2 production
F	0035556	biological_process	intracellular signal transduction
F	0038023	molecular_function	signaling receptor activity
F	0042802	molecular_function	identical protein binding
F	0043008	molecular_function	ATP-dependent protein binding
F	0043066	biological_process	negative regulation of apoptotic process
F	0043195	cellular_component	terminal bouton
F	0043525	biological_process	positive regulation of neuron apoptotic process
F	0044325	molecular_function	transmembrane transporter binding
F	0044877	molecular_function	protein-containing complex binding
F	0045121	cellular_component	membrane raft
F	0046007	biological_process	negative regulation of activated T cell proliferation
F	0046686	biological_process	response to cadmium ion
F	0046688	biological_process	response to copper ion
F	0046872	molecular_function	metal ion binding
F	0050850	biological_process	positive regulation of calcium-mediated signaling
F	0050860	biological_process	negative regulation of T cell receptor signaling pathway
F	0051087	molecular_function	protein-folding chaperone binding
F	0051260	biological_process	protein homooligomerization
F	0051726	biological_process	regulation of cell cycle
F	0060090	molecular_function	molecular adaptor activity
F	0070062	cellular_component	extracellular exosome
F	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
F	0071280	biological_process	cellular response to copper ion
F	0090314	biological_process	positive regulation of protein targeting to membrane
F	0097062	biological_process	dendritic spine maintenance
F	0098552	cellular_component	side of membrane
F	0098794	cellular_component	postsynapse
F	0140677	molecular_function	molecular function activator activity
F	0140693	molecular_function	molecular condensate scaffold activity
F	1900272	biological_process	negative regulation of long-term synaptic potentiation
F	1900449	biological_process	regulation of glutamate receptor signaling pathway
F	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
F	1902430	biological_process	negative regulation of amyloid-beta formation
F	1902951	biological_process	negative regulation of dendritic spine maintenance
F	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
F	1903078	biological_process	positive regulation of protein localization to plasma membrane
F	1903135	molecular_function	cupric ion binding
F	1903136	molecular_function	cuprous ion binding
F	1904645	biological_process	response to amyloid-beta
F	1904646	biological_process	cellular response to amyloid-beta
F	1905664	biological_process	regulation of calcium ion import across plasma membrane
F	1990535	biological_process	neuron projection maintenance
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0001540	molecular_function	amyloid-beta binding
G	0002020	molecular_function	protease binding
G	0005507	molecular_function	copper ion binding
G	0005515	molecular_function	protein binding
G	0005521	molecular_function	lamin binding
G	0005539	molecular_function	glycosaminoglycan binding
G	0005737	cellular_component	cytoplasm
G	0005783	cellular_component	endoplasmic reticulum
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006878	biological_process	intracellular copper ion homeostasis
G	0006979	biological_process	response to oxidative stress
G	0007611	biological_process	learning or memory
G	0007616	biological_process	long-term memory
G	0008017	molecular_function	microtubule binding
G	0009897	cellular_component	external side of plasma membrane
G	0009986	cellular_component	cell surface
G	0010955	biological_process	negative regulation of protein processing
G	0014069	cellular_component	postsynaptic density
G	0015631	molecular_function	tubulin binding
G	0016020	cellular_component	membrane
G	0016234	cellular_component	inclusion body
G	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
G	0019898	cellular_component	extrinsic component of membrane
G	0030425	cellular_component	dendrite
G	0031648	biological_process	protein destabilization
G	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
G	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
G	0032689	biological_process	negative regulation of type II interferon production
G	0032700	biological_process	negative regulation of interleukin-17 production
G	0032703	biological_process	negative regulation of interleukin-2 production
G	0035556	biological_process	intracellular signal transduction
G	0038023	molecular_function	signaling receptor activity
G	0042802	molecular_function	identical protein binding
G	0043008	molecular_function	ATP-dependent protein binding
G	0043066	biological_process	negative regulation of apoptotic process
G	0043195	cellular_component	terminal bouton
G	0043525	biological_process	positive regulation of neuron apoptotic process
G	0044325	molecular_function	transmembrane transporter binding
G	0044877	molecular_function	protein-containing complex binding
G	0045121	cellular_component	membrane raft
G	0046007	biological_process	negative regulation of activated T cell proliferation
G	0046686	biological_process	response to cadmium ion
G	0046688	biological_process	response to copper ion
G	0046872	molecular_function	metal ion binding
G	0050850	biological_process	positive regulation of calcium-mediated signaling
G	0050860	biological_process	negative regulation of T cell receptor signaling pathway
G	0051087	molecular_function	protein-folding chaperone binding
G	0051260	biological_process	protein homooligomerization
G	0051726	biological_process	regulation of cell cycle
G	0060090	molecular_function	molecular adaptor activity
G	0070062	cellular_component	extracellular exosome
G	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
G	0071280	biological_process	cellular response to copper ion
G	0090314	biological_process	positive regulation of protein targeting to membrane
G	0097062	biological_process	dendritic spine maintenance
G	0098552	cellular_component	side of membrane
G	0098794	cellular_component	postsynapse
G	0140677	molecular_function	molecular function activator activity
G	0140693	molecular_function	molecular condensate scaffold activity
G	1900272	biological_process	negative regulation of long-term synaptic potentiation
G	1900449	biological_process	regulation of glutamate receptor signaling pathway
G	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
G	1902430	biological_process	negative regulation of amyloid-beta formation
G	1902951	biological_process	negative regulation of dendritic spine maintenance
G	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
G	1903078	biological_process	positive regulation of protein localization to plasma membrane
G	1903135	molecular_function	cupric ion binding
G	1903136	molecular_function	cuprous ion binding
G	1904645	biological_process	response to amyloid-beta
G	1904646	biological_process	cellular response to amyloid-beta
G	1905664	biological_process	regulation of calcium ion import across plasma membrane
G	1990535	biological_process	neuron projection maintenance
H	0000122	biological_process	negative regulation of transcription by RNA polymerase II
H	0001540	molecular_function	amyloid-beta binding
H	0002020	molecular_function	protease binding
H	0005507	molecular_function	copper ion binding
H	0005515	molecular_function	protein binding
H	0005521	molecular_function	lamin binding
H	0005539	molecular_function	glycosaminoglycan binding
H	0005737	cellular_component	cytoplasm
H	0005783	cellular_component	endoplasmic reticulum
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006878	biological_process	intracellular copper ion homeostasis
H	0006979	biological_process	response to oxidative stress
H	0007611	biological_process	learning or memory
H	0007616	biological_process	long-term memory
H	0008017	molecular_function	microtubule binding
H	0009897	cellular_component	external side of plasma membrane
H	0009986	cellular_component	cell surface
H	0010955	biological_process	negative regulation of protein processing
H	0014069	cellular_component	postsynaptic density
H	0015631	molecular_function	tubulin binding
H	0016020	cellular_component	membrane
H	0016234	cellular_component	inclusion body
H	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
H	0019898	cellular_component	extrinsic component of membrane
H	0030425	cellular_component	dendrite
H	0031648	biological_process	protein destabilization
H	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
H	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
H	0032689	biological_process	negative regulation of type II interferon production
H	0032700	biological_process	negative regulation of interleukin-17 production
H	0032703	biological_process	negative regulation of interleukin-2 production
H	0035556	biological_process	intracellular signal transduction
H	0038023	molecular_function	signaling receptor activity
H	0042802	molecular_function	identical protein binding
H	0043008	molecular_function	ATP-dependent protein binding
H	0043066	biological_process	negative regulation of apoptotic process
H	0043195	cellular_component	terminal bouton
H	0043525	biological_process	positive regulation of neuron apoptotic process
H	0044325	molecular_function	transmembrane transporter binding
H	0044877	molecular_function	protein-containing complex binding
H	0045121	cellular_component	membrane raft
H	0046007	biological_process	negative regulation of activated T cell proliferation
H	0046686	biological_process	response to cadmium ion
H	0046688	biological_process	response to copper ion
H	0046872	molecular_function	metal ion binding
H	0050850	biological_process	positive regulation of calcium-mediated signaling
H	0050860	biological_process	negative regulation of T cell receptor signaling pathway
H	0051087	molecular_function	protein-folding chaperone binding
H	0051260	biological_process	protein homooligomerization
H	0051726	biological_process	regulation of cell cycle
H	0060090	molecular_function	molecular adaptor activity
H	0070062	cellular_component	extracellular exosome
H	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
H	0071280	biological_process	cellular response to copper ion
H	0090314	biological_process	positive regulation of protein targeting to membrane
H	0097062	biological_process	dendritic spine maintenance
H	0098552	cellular_component	side of membrane
H	0098794	cellular_component	postsynapse
H	0140677	molecular_function	molecular function activator activity
H	0140693	molecular_function	molecular condensate scaffold activity
H	1900272	biological_process	negative regulation of long-term synaptic potentiation
H	1900449	biological_process	regulation of glutamate receptor signaling pathway
H	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
H	1902430	biological_process	negative regulation of amyloid-beta formation
H	1902951	biological_process	negative regulation of dendritic spine maintenance
H	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
H	1903078	biological_process	positive regulation of protein localization to plasma membrane
H	1903135	molecular_function	cupric ion binding
H	1903136	molecular_function	cuprous ion binding
H	1904645	biological_process	response to amyloid-beta
H	1904646	biological_process	cellular response to amyloid-beta
H	1905664	biological_process	regulation of calcium ion import across plasma membrane
H	1990535	biological_process	neuron projection maintenance
I	0000122	biological_process	negative regulation of transcription by RNA polymerase II
I	0001540	molecular_function	amyloid-beta binding
I	0002020	molecular_function	protease binding
I	0005507	molecular_function	copper ion binding
I	0005515	molecular_function	protein binding
I	0005521	molecular_function	lamin binding
I	0005539	molecular_function	glycosaminoglycan binding
I	0005737	cellular_component	cytoplasm
I	0005783	cellular_component	endoplasmic reticulum
I	0005794	cellular_component	Golgi apparatus
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006878	biological_process	intracellular copper ion homeostasis
I	0006979	biological_process	response to oxidative stress
I	0007611	biological_process	learning or memory
I	0007616	biological_process	long-term memory
I	0008017	molecular_function	microtubule binding
I	0009897	cellular_component	external side of plasma membrane
I	0009986	cellular_component	cell surface
I	0010955	biological_process	negative regulation of protein processing
I	0014069	cellular_component	postsynaptic density
I	0015631	molecular_function	tubulin binding
I	0016020	cellular_component	membrane
I	0016234	cellular_component	inclusion body
I	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
I	0019898	cellular_component	extrinsic component of membrane
I	0030425	cellular_component	dendrite
I	0031648	biological_process	protein destabilization
I	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
I	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
I	0032689	biological_process	negative regulation of type II interferon production
I	0032700	biological_process	negative regulation of interleukin-17 production
I	0032703	biological_process	negative regulation of interleukin-2 production
I	0035556	biological_process	intracellular signal transduction
I	0038023	molecular_function	signaling receptor activity
I	0042802	molecular_function	identical protein binding
I	0043008	molecular_function	ATP-dependent protein binding
I	0043066	biological_process	negative regulation of apoptotic process
I	0043195	cellular_component	terminal bouton
I	0043525	biological_process	positive regulation of neuron apoptotic process
I	0044325	molecular_function	transmembrane transporter binding
I	0044877	molecular_function	protein-containing complex binding
I	0045121	cellular_component	membrane raft
I	0046007	biological_process	negative regulation of activated T cell proliferation
I	0046686	biological_process	response to cadmium ion
I	0046688	biological_process	response to copper ion
I	0046872	molecular_function	metal ion binding
I	0050850	biological_process	positive regulation of calcium-mediated signaling
I	0050860	biological_process	negative regulation of T cell receptor signaling pathway
I	0051087	molecular_function	protein-folding chaperone binding
I	0051260	biological_process	protein homooligomerization
I	0051726	biological_process	regulation of cell cycle
I	0060090	molecular_function	molecular adaptor activity
I	0070062	cellular_component	extracellular exosome
I	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
I	0071280	biological_process	cellular response to copper ion
I	0090314	biological_process	positive regulation of protein targeting to membrane
I	0097062	biological_process	dendritic spine maintenance
I	0098552	cellular_component	side of membrane
I	0098794	cellular_component	postsynapse
I	0140677	molecular_function	molecular function activator activity
I	0140693	molecular_function	molecular condensate scaffold activity
I	1900272	biological_process	negative regulation of long-term synaptic potentiation
I	1900449	biological_process	regulation of glutamate receptor signaling pathway
I	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
I	1902430	biological_process	negative regulation of amyloid-beta formation
I	1902951	biological_process	negative regulation of dendritic spine maintenance
I	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
I	1903078	biological_process	positive regulation of protein localization to plasma membrane
I	1903135	molecular_function	cupric ion binding
I	1903136	molecular_function	cuprous ion binding
I	1904645	biological_process	response to amyloid-beta
I	1904646	biological_process	cellular response to amyloid-beta
I	1905664	biological_process	regulation of calcium ion import across plasma membrane
I	1990535	biological_process	neuron projection maintenance
J	0000122	biological_process	negative regulation of transcription by RNA polymerase II
J	0001540	molecular_function	amyloid-beta binding
J	0002020	molecular_function	protease binding
J	0005507	molecular_function	copper ion binding
J	0005515	molecular_function	protein binding
J	0005521	molecular_function	lamin binding
J	0005539	molecular_function	glycosaminoglycan binding
J	0005737	cellular_component	cytoplasm
J	0005783	cellular_component	endoplasmic reticulum
J	0005794	cellular_component	Golgi apparatus
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006878	biological_process	intracellular copper ion homeostasis
J	0006979	biological_process	response to oxidative stress
J	0007611	biological_process	learning or memory
J	0007616	biological_process	long-term memory
J	0008017	molecular_function	microtubule binding
J	0009897	cellular_component	external side of plasma membrane
J	0009986	cellular_component	cell surface
J	0010955	biological_process	negative regulation of protein processing
J	0014069	cellular_component	postsynaptic density
J	0015631	molecular_function	tubulin binding
J	0016020	cellular_component	membrane
J	0016234	cellular_component	inclusion body
J	0019828	molecular_function	aspartic-type endopeptidase inhibitor activity
J	0019898	cellular_component	extrinsic component of membrane
J	0030425	cellular_component	dendrite
J	0031648	biological_process	protein destabilization
J	0031802	molecular_function	type 5 metabotropic glutamate receptor binding
J	0031805	molecular_function	type 8 metabotropic glutamate receptor binding
J	0032689	biological_process	negative regulation of type II interferon production
J	0032700	biological_process	negative regulation of interleukin-17 production
J	0032703	biological_process	negative regulation of interleukin-2 production
J	0035556	biological_process	intracellular signal transduction
J	0038023	molecular_function	signaling receptor activity
J	0042802	molecular_function	identical protein binding
J	0043008	molecular_function	ATP-dependent protein binding
J	0043066	biological_process	negative regulation of apoptotic process
J	0043195	cellular_component	terminal bouton
J	0043525	biological_process	positive regulation of neuron apoptotic process
J	0044325	molecular_function	transmembrane transporter binding
J	0044877	molecular_function	protein-containing complex binding
J	0045121	cellular_component	membrane raft
J	0046007	biological_process	negative regulation of activated T cell proliferation
J	0046686	biological_process	response to cadmium ion
J	0046688	biological_process	response to copper ion
J	0046872	molecular_function	metal ion binding
J	0050850	biological_process	positive regulation of calcium-mediated signaling
J	0050860	biological_process	negative regulation of T cell receptor signaling pathway
J	0051087	molecular_function	protein-folding chaperone binding
J	0051260	biological_process	protein homooligomerization
J	0051726	biological_process	regulation of cell cycle
J	0060090	molecular_function	molecular adaptor activity
J	0070062	cellular_component	extracellular exosome
J	0070885	biological_process	negative regulation of calcineurin-NFAT signaling cascade
J	0071280	biological_process	cellular response to copper ion
J	0090314	biological_process	positive regulation of protein targeting to membrane
J	0097062	biological_process	dendritic spine maintenance
J	0098552	cellular_component	side of membrane
J	0098794	cellular_component	postsynapse
J	0140677	molecular_function	molecular function activator activity
J	0140693	molecular_function	molecular condensate scaffold activity
J	1900272	biological_process	negative regulation of long-term synaptic potentiation
J	1900449	biological_process	regulation of glutamate receptor signaling pathway
J	1900451	biological_process	positive regulation of glutamate receptor signaling pathway
J	1902430	biological_process	negative regulation of amyloid-beta formation
J	1902951	biological_process	negative regulation of dendritic spine maintenance
J	1902992	biological_process	negative regulation of amyloid precursor protein catabolic process
J	1903078	biological_process	positive regulation of protein localization to plasma membrane
J	1903135	molecular_function	cupric ion binding
J	1903136	molecular_function	cuprous ion binding
J	1904645	biological_process	response to amyloid-beta
J	1904646	biological_process	cellular response to amyloid-beta
J	1905664	biological_process	regulation of calcium ion import across plasma membrane
J	1990535	biological_process	neuron projection maintenance

Functional Information from PROSITE/UniProt

site_id	PS00291
Number of Residues	16
Details	PRION_1 Prion protein signature 1. AGAAAAGAVVGGLGGY

Chain	Residue	Details
A	ALA113-TYR128

---

site_id	PS00706
Number of Residues	19
Details	PRION_2 Prion protein signature 2. EtDvKMMeRVVeQMCitQY

Chain	Residue	Details
A	GLU200-TYR218

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12214108","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---