6LMW

Cryo-EM structure of the CALHM chimeric construct (8-mer)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005227	molecular_function	calcium activated cation channel activity
A	0005244	molecular_function	voltage-gated ion channel activity
A	0006812	biological_process	cation transport
B	0005227	molecular_function	calcium activated cation channel activity
B	0005244	molecular_function	voltage-gated ion channel activity
B	0006812	biological_process	cation transport
C	0005227	molecular_function	calcium activated cation channel activity
C	0005244	molecular_function	voltage-gated ion channel activity
C	0006812	biological_process	cation transport
D	0005227	molecular_function	calcium activated cation channel activity
D	0005244	molecular_function	voltage-gated ion channel activity
D	0006812	biological_process	cation transport
E	0005227	molecular_function	calcium activated cation channel activity
E	0005244	molecular_function	voltage-gated ion channel activity
E	0006812	biological_process	cation transport
F	0005227	molecular_function	calcium activated cation channel activity
F	0005244	molecular_function	voltage-gated ion channel activity
F	0006812	biological_process	cation transport
G	0005227	molecular_function	calcium activated cation channel activity
G	0005244	molecular_function	voltage-gated ion channel activity
G	0006812	biological_process	cation transport
H	0005227	molecular_function	calcium activated cation channel activity
H	0005244	molecular_function	voltage-gated ion channel activity
H	0006812	biological_process	cation transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	360
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	MET1-ASN20
E	ASN72-MET98
F	MET1-ASN20
F	ASN72-MET98
G	MET1-ASN20
G	ASN72-MET98
H	MET1-ASN20
H	ASN72-MET98
A	ASN72-MET98
B	MET1-ASN20
B	ASN72-MET98
C	MET1-ASN20
C	ASN72-MET98
D	MET1-ASN20
D	ASN72-MET98
E	MET1-ASN20

---

site_id	SWS_FT_FI2
Number of Residues	120
Details	TRANSMEM: Helical; Name=S1 => ECO:0000269|PubMed:32832629, ECO:0007744|PDB:6LMT

Chain	Residue	Details
A	GLY21-SER36
B	GLY21-SER36
C	GLY21-SER36
D	GLY21-SER36
E	GLY21-SER36
F	GLY21-SER36
G	GLY21-SER36
H	GLY21-SER36

---

site_id	SWS_FT_FI3
Number of Residues	504
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	PHE37-ASN48
E	LEU125-ILE177
F	PHE37-ASN48
F	LEU125-ILE177
G	PHE37-ASN48
G	LEU125-ILE177
H	PHE37-ASN48
H	LEU125-ILE177
A	LEU125-ILE177
B	PHE37-ASN48
B	LEU125-ILE177
C	PHE37-ASN48
C	LEU125-ILE177
D	PHE37-ASN48
D	LEU125-ILE177
E	PHE37-ASN48

---

site_id	SWS_FT_FI4
Number of Residues	176
Details	TRANSMEM: Helical; Name=S2 => ECO:0000269|PubMed:32832629, ECO:0007744|PDB:6LMT

Chain	Residue	Details
A	TYR49-ASN71
B	TYR49-ASN71
C	TYR49-ASN71
D	TYR49-ASN71
E	TYR49-ASN71
F	TYR49-ASN71
G	TYR49-ASN71
H	TYR49-ASN71

---

site_id	SWS_FT_FI5
Number of Residues	200
Details	TRANSMEM: Helical; Name=S3 => ECO:0000269|PubMed:32832629, ECO:0007744|PDB:6LMT

Chain	Residue	Details
A	LEU99-PHE124
B	LEU99-PHE124
C	LEU99-PHE124
D	LEU99-PHE124
E	LEU99-PHE124
F	LEU99-PHE124
G	LEU99-PHE124
H	LEU99-PHE124

---

site_id	SWS_FT_FI6
Number of Residues	200
Details	TRANSMEM: Helical; Name=S4 => ECO:0000269|PubMed:32832629, ECO:0007744|PDB:6LMT

Chain	Residue	Details
A	LYS178-ARG203
B	LYS178-ARG203
C	LYS178-ARG203
D	LYS178-ARG203
E	LYS178-ARG203
F	LYS178-ARG203
G	LYS178-ARG203
H	LYS178-ARG203

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:D3Z291

Chain	Residue	Details
A	CYS100
E	CYS205
F	CYS100
F	CYS205
G	CYS100
G	CYS205
H	CYS100
H	CYS205
A	CYS205
B	CYS100
B	CYS205
C	CYS100
C	CYS205
D	CYS100
D	CYS205
E	CYS100

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000250|UniProtKB:Q8IU99

Chain	Residue	Details
A	ASN139
B	ASN139
C	ASN139
D	ASN139
E	ASN139
F	ASN139
G	ASN139
H	ASN139

---