6LKY
Crystal structure of isocitrate dehydrogenase from Methylococcus capsulatus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004449 | molecular_function | isocitrate dehydrogenase (NAD+) activity |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006102 | biological_process | isocitrate metabolic process |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0051287 | molecular_function | NAD binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004449 | molecular_function | isocitrate dehydrogenase (NAD+) activity |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006102 | biological_process | isocitrate metabolic process |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | binding site for residue NAD A 501 |
| Chain | Residue |
| A | LYS66 |
| A | VAL262 |
| A | HIS263 |
| A | GLY264 |
| A | SER265 |
| A | ALA266 |
| A | ASP268 |
| A | ILE269 |
| A | ASN276 |
| A | ACE502 |
| A | CIT503 |
| A | PRO68 |
| A | HOH620 |
| A | HOH626 |
| A | HOH682 |
| A | HOH684 |
| A | HOH710 |
| B | ASN176 |
| B | ILE205 |
| B | ALA208 |
| B | HOH532 |
| A | LEU69 |
| A | THR70 |
| A | THR71 |
| A | ASN81 |
| A | LEU244 |
| A | GLY245 |
| A | GLU260 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ACE A 502 |
| Chain | Residue |
| A | LEU244 |
| A | GLY245 |
| A | NAD501 |
| A | HOH602 |
| B | MET211 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue CIT A 503 |
| Chain | Residue |
| A | THR71 |
| A | SER79 |
| A | ASN81 |
| A | ARG85 |
| A | ARG95 |
| A | ARG116 |
| A | TYR123 |
| A | ASP231 |
| A | NAD501 |
| A | HOH619 |
| B | LYS174 |
| B | ASN176 |
| B | ILE177 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 504 |
| Chain | Residue |
| A | LYS168 |
| A | THR170 |
| A | ASP202 |
| A | ARG204 |
| A | PHE220 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ACE A 505 |
| Chain | Residue |
| A | VAL214 |
| A | HOH717 |
| B | ALA106 |
| B | HOH544 |
| B | HOH549 |
| site_id | AC6 |
| Number of Residues | 24 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| A | ASN176 |
| A | ILE205 |
| A | HOH649 |
| B | ILE12 |
| B | LYS66 |
| B | PRO68 |
| B | LEU69 |
| B | THR70 |
| B | THR71 |
| B | ASN81 |
| B | GLY245 |
| B | GLU260 |
| B | VAL262 |
| B | HIS263 |
| B | GLY264 |
| B | SER265 |
| B | ALA266 |
| B | ASP268 |
| B | ALA275 |
| B | ASN276 |
| B | CIT406 |
| B | HOH525 |
| B | HOH582 |
| B | HOH645 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue ACE B 402 |
| Chain | Residue |
| A | ILE177 |
| B | LEU122 |
| B | GLY125 |
| B | ILE126 |
| B | GLU127 |
| B | ILE142 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue ACE B 403 |
| Chain | Residue |
| B | GLY102 |
| B | GLU309 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue ACE B 404 |
| Chain | Residue |
| B | ARG78 |
| B | THR83 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 405 |
| Chain | Residue |
| A | ALA124 |
| B | PHE129 |
| B | ILE130 |
| B | LYS131 |
| site_id | AD2 |
| Number of Residues | 13 |
| Details | binding site for residue CIT B 406 |
| Chain | Residue |
| B | ASN81 |
| B | ARG85 |
| B | ARG95 |
| B | ARG116 |
| B | TYR123 |
| B | ASP231 |
| B | NAD401 |
| B | HOH554 |
| A | LYS174 |
| A | ASN176 |
| A | HOH690 |
| B | THR71 |
| B | SER79 |
Functional Information from PROSITE/UniProt
| site_id | PS00470 |
| Number of Residues | 20 |
| Details | IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NLFGDIlSDlaAgli.GGLGL |
| Chain | Residue | Details |
| A | ASN227-LEU246 |
