Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046294 | biological_process | formaldehyde catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051903 | molecular_function | S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | CYS48 |
| A | ASP226 |
| A | VAL227 |
| A | LYS231 |
| A | CYS273 |
| A | THR274 |
| A | GLY275 |
| A | VAL276 |
| A | ILE297 |
| A | GLY298 |
| A | ALA299 |
| A | HIS49 |
| A | NA408 |
| A | NA409 |
| A | HOH508 |
| A | HOH532 |
| A | HOH548 |
| A | HOH549 |
| A | HOH569 |
| A | HOH592 |
| A | HOH646 |
| A | HOH648 |
| A | THR50 |
| A | HOH664 |
| A | HOH690 |
| A | HOH698 |
| A | CYS177 |
| A | THR181 |
| A | GLY202 |
| A | GLY204 |
| A | THR205 |
| A | VAL206 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 402 |
| Chain | Residue |
| A | CYS99 |
| A | CYS102 |
| A | CYS105 |
| A | CYS113 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 403 |
| Chain | Residue |
| A | CYS48 |
| A | HIS69 |
| A | GLU70 |
| A | CYS177 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | SER20 |
| A | GLY21 |
| A | PRO22 |
| A | VAL23 |
| A | THR55 |
| A | LYS56 |
| A | GLN360 |
| A | PHE363 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | MET124 |
| A | HIS142 |
| A | ALA144 |
| A | SER145 |
| A | ASP156 |
| A | TYR159 |
| A | HOH502 |
| A | HOH554 |
| A | HOH619 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 406 |
| Chain | Residue |
| A | GLU285 |
| A | ILE289 |
| A | LEU310 |
| A | ILE311 |
| A | ARG316 |
| A | HOH605 |
| A | HOH607 |
| A | HOH795 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 407 |
| Chain | Residue |
| A | GLY275 |
| A | PRO277 |
| A | LEU280 |
| A | GLY298 |
| A | GLY300 |
| A | LEU312 |
| A | HOH540 |
| A | HOH544 |
| A | HOH671 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 408 |
| Chain | Residue |
| A | CYS48 |
| A | HIS49 |
| A | NAD401 |
| A | HOH690 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 409 |
| Chain | Residue |
| A | ILE297 |
| A | NAD401 |
| A | HOH869 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 410 |
| Chain | Residue |
| A | MET42 |
| A | GLU380 |
| A | HOH848 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 411 |
| Chain | Residue |
| A | ALA35 |
| A | SER36 |
| A | ASP156 |
| A | HOH568 |
Functional Information from PROSITE/UniProt
| site_id | PS00059 |
| Number of Residues | 15 |
| Details | ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEgVGViesiGkdA |
| Chain | Residue | Details |
| A | GLY68-ALA82 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | CYS48 | |
| A | ASP226 | |
| A | LYS231 | |
| A | THR274 | |
| A | ILE297 | |
| A | THR321 | |
| A | HIS49 | |
| A | HIS69 | |
| A | CYS99 | |
| A | CYS102 | |
| A | CYS105 | |
| A | CYS113 | |
| A | CYS177 | |
| A | GLY202 | |
