6LJ8

Crystal structure of NDM-1 in complex with D-captopril derivative wss04134

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue EG0 A 301

Chain	Residue
A	TRP93
A	HOH500
A	HOH514
A	HIS122
A	ASP124
A	HIS189
A	ASN220
A	HIS250
A	ZN305
A	ZN306
A	HOH430

---

site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 302

Chain	Residue
A	GLN151
A	GLY153
A	HOH420

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 303

Chain	Residue
A	THR94
A	GLN123
A	HOH438
A	HOH469
A	HOH591

---

site_id	AC4
Number of Residues	6
Details	binding site for residue EDO A 304

Chain	Residue
A	HIS133
A	GLY237
A	ARG256
A	ILE259
A	HOH426
A	HOH485

---

site_id	AC5
Number of Residues	5
Details	binding site for residue ZN A 305

Chain	Residue
A	HIS120
A	HIS122
A	HIS189
A	EG0301
A	ZN306

---

site_id	AC6
Number of Residues	5
Details	binding site for residue ZN A 306

Chain	Residue
A	ASP124
A	CYS208
A	HIS250
A	EG0301
A	ZN305

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22713171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25815530","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22713171","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---