6LIV

Crystal structure of Tyrosine decarboxylase in complex with PLP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
A	0004837	molecular_function	tyrosine decarboxylase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0016829	molecular_function	lyase activity
A	0016830	molecular_function	carbon-carbon lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0019752	biological_process	carboxylic acid metabolic process
A	0030170	molecular_function	pyridoxal phosphate binding
A	0036467	molecular_function	5-hydroxy-L-tryptophan decarboxylase activity
A	0036468	molecular_function	L-dopa decarboxylase activity
B	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
B	0004837	molecular_function	tyrosine decarboxylase activity
B	0005737	cellular_component	cytoplasm
B	0006520	biological_process	amino acid metabolic process
B	0016829	molecular_function	lyase activity
B	0016830	molecular_function	carbon-carbon lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0019752	biological_process	carboxylic acid metabolic process
B	0030170	molecular_function	pyridoxal phosphate binding
B	0036467	molecular_function	5-hydroxy-L-tryptophan decarboxylase activity
B	0036468	molecular_function	L-dopa decarboxylase activity
C	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
C	0004837	molecular_function	tyrosine decarboxylase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0016829	molecular_function	lyase activity
C	0016830	molecular_function	carbon-carbon lyase activity
C	0016831	molecular_function	carboxy-lyase activity
C	0019752	biological_process	carboxylic acid metabolic process
C	0030170	molecular_function	pyridoxal phosphate binding
C	0036467	molecular_function	5-hydroxy-L-tryptophan decarboxylase activity
C	0036468	molecular_function	L-dopa decarboxylase activity
D	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
D	0004837	molecular_function	tyrosine decarboxylase activity
D	0005737	cellular_component	cytoplasm
D	0006520	biological_process	amino acid metabolic process
D	0016829	molecular_function	lyase activity
D	0016830	molecular_function	carbon-carbon lyase activity
D	0016831	molecular_function	carboxy-lyase activity
D	0019752	biological_process	carboxylic acid metabolic process
D	0030170	molecular_function	pyridoxal phosphate binding
D	0036467	molecular_function	5-hydroxy-L-tryptophan decarboxylase activity
D	0036468	molecular_function	L-dopa decarboxylase activity
E	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
E	0004837	molecular_function	tyrosine decarboxylase activity
E	0005737	cellular_component	cytoplasm
E	0006520	biological_process	amino acid metabolic process
E	0016829	molecular_function	lyase activity
E	0016830	molecular_function	carbon-carbon lyase activity
E	0016831	molecular_function	carboxy-lyase activity
E	0019752	biological_process	carboxylic acid metabolic process
E	0030170	molecular_function	pyridoxal phosphate binding
E	0036467	molecular_function	5-hydroxy-L-tryptophan decarboxylase activity
E	0036468	molecular_function	L-dopa decarboxylase activity
F	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
F	0004837	molecular_function	tyrosine decarboxylase activity
F	0005737	cellular_component	cytoplasm
F	0006520	biological_process	amino acid metabolic process
F	0016829	molecular_function	lyase activity
F	0016830	molecular_function	carbon-carbon lyase activity
F	0016831	molecular_function	carboxy-lyase activity
F	0019752	biological_process	carboxylic acid metabolic process
F	0030170	molecular_function	pyridoxal phosphate binding
F	0036467	molecular_function	5-hydroxy-L-tryptophan decarboxylase activity
F	0036468	molecular_function	L-dopa decarboxylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue GOL A 601

Chain	Residue
A	HIS203
A	LLP319
B	PHE124
B	LEU369
B	SER370

---

site_id	AC2
Number of Residues	7
Details	binding site for residue GOL B 601

Chain	Residue
B	HIS203
B	LLP319
B	GOL602
A	PHE124
A	LEU369
A	SER370
B	TYR100

---

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL B 602

Chain	Residue
A	PHE124
B	HIS203
B	CYS204
B	THR262
B	GOL601
B	GOL603

---

site_id	AC4
Number of Residues	8
Details	binding site for residue GOL B 603

Chain	Residue
B	TYR100
B	THR262
B	SER263
B	THR482
B	HIS483
B	ARG493
B	GOL602
B	HOH774

---

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL C 601

Chain	Residue
C	TYR100
C	HIS203
C	LLP319
C	GOL602
D	SER370

---

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL C 602

Chain	Residue
C	HIS203
C	CYS204
C	THR262
C	GOL601
C	GOL603

---

site_id	AC7
Number of Residues	6
Details	binding site for residue GOL C 603

Chain	Residue
C	THR262
C	SER263
C	THR482
C	HIS483
C	ARG493
C	GOL602

---

site_id	AC8
Number of Residues	7
Details	binding site for residue GOL D 601

Chain	Residue
C	PHE124
C	LEU369
C	SER370
D	TYR100
D	HIS203
D	LLP319
D	GOL602

---

site_id	AC9
Number of Residues	4
Details	binding site for residue GOL D 602

Chain	Residue
D	HIS203
D	CYS204
D	THR262
D	GOL601

---

Functional Information from PROSITE/UniProt

site_id	PS00392
Number of Residues	22
Details	DDC_GAD_HDC_YDC DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. SFsLnahKWFfTtLDCccLWvK

Chain	Residue	Details
A	SER312-LYS333

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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