6LIO
Crystal structure of human PDK2 complexed with GM67520
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004740 | molecular_function | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006111 | biological_process | regulation of gluconeogenesis |
| A | 0006885 | biological_process | regulation of pH |
| A | 0008286 | biological_process | insulin receptor signaling pathway |
| A | 0010510 | biological_process | regulation of pyruvate decarboxylation to acetyl-CoA |
| A | 0010565 | biological_process | regulation of ketone metabolic process |
| A | 0010906 | biological_process | regulation of glucose metabolic process |
| A | 0031670 | biological_process | cellular response to nutrient |
| A | 0033554 | biological_process | cellular response to stress |
| A | 0034614 | biological_process | cellular response to reactive oxygen species |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| A | 0072332 | biological_process | intrinsic apoptotic signaling pathway by p53 class mediator |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004740 | molecular_function | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0006111 | biological_process | regulation of gluconeogenesis |
| B | 0006885 | biological_process | regulation of pH |
| B | 0008286 | biological_process | insulin receptor signaling pathway |
| B | 0010510 | biological_process | regulation of pyruvate decarboxylation to acetyl-CoA |
| B | 0010565 | biological_process | regulation of ketone metabolic process |
| B | 0010906 | biological_process | regulation of glucose metabolic process |
| B | 0031670 | biological_process | cellular response to nutrient |
| B | 0033554 | biological_process | cellular response to stress |
| B | 0034614 | biological_process | cellular response to reactive oxygen species |
| B | 0042593 | biological_process | glucose homeostasis |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| B | 0072332 | biological_process | intrinsic apoptotic signaling pathway by p53 class mediator |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | PHE39 |
| A | SER49 |
| A | PHE52 |
| A | LEU168 |
| A | GLN171 |
| A | HIS172 |
| A | ILE175 |
| A | HOH528 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | LYS299 |
| A | ARG302 |
| A | ARG298 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | LYS233 |
| B | ARG298 |
| B | LYS299 |
| B | ARG302 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | ARG162 |
| A | ARG166 |
| A | ASN170 |
| A | HOH527 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | binding site for residue EH3 A 405 |
| Chain | Residue |
| A | LEU252 |
| A | ASN255 |
| A | ARG258 |
| A | ALA259 |
| A | ASP290 |
| A | GLY294 |
| A | VAL295 |
| A | LYS299 |
| A | ARG302 |
| A | LEU303 |
| A | SER305 |
| A | TYR308 |
| A | GLY327 |
| A | TYR328 |
| A | GLY329 |
| A | LEU330 |
| A | PRO331 |
| A | LEU346 |
| A | THR354 |
| A | HOH540 |
| A | HOH556 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 401 |
| Chain | Residue |
| B | ARG157 |
| B | LEU371 |
| B | PRO372 |
| B | VAL373 |
| B | ASN375 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| B | PHE39 |
| B | SER49 |
| B | PHE52 |
| B | HOH602 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | ARG166 |
| B | ASN170 |
| B | SER243 |
| B | HIS247 |
| site_id | AC9 |
| Number of Residues | 20 |
| Details | binding site for residue EH3 B 404 |
| Chain | Residue |
| B | LEU252 |
| B | ASN255 |
| B | ARG258 |
| B | ALA259 |
| B | ASP290 |
| B | GLY294 |
| B | VAL295 |
| B | LYS299 |
| B | LEU303 |
| B | SER305 |
| B | TYR308 |
| B | GLY327 |
| B | TYR328 |
| B | GLY329 |
| B | LEU330 |
| B | PRO331 |
| B | LEU346 |
| B | THR354 |
| B | HOH528 |
| B | HOH562 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 26 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16401071","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q15118","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8BFP9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
