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6LIO

Crystal structure of human PDK2 complexed with GM67520

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004740molecular_functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005654cellular_componentnucleoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006006biological_processglucose metabolic process
A0006111biological_processregulation of gluconeogenesis
A0006885biological_processregulation of pH
A0008286biological_processinsulin receptor signaling pathway
A0010510biological_processregulation of acetyl-CoA biosynthetic process from pyruvate
A0010565biological_processregulation of cellular ketone metabolic process
A0010906biological_processregulation of glucose metabolic process
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0031670biological_processcellular response to nutrient
A0034614biological_processcellular response to reactive oxygen species
A0042593biological_processglucose homeostasis
A0042803molecular_functionprotein homodimerization activity
A0045254cellular_componentpyruvate dehydrogenase complex
A0050848biological_processregulation of calcium-mediated signaling
A0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
B0004672molecular_functionprotein kinase activity
B0004740molecular_functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005654cellular_componentnucleoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006006biological_processglucose metabolic process
B0006111biological_processregulation of gluconeogenesis
B0006885biological_processregulation of pH
B0008286biological_processinsulin receptor signaling pathway
B0010510biological_processregulation of acetyl-CoA biosynthetic process from pyruvate
B0010565biological_processregulation of cellular ketone metabolic process
B0010906biological_processregulation of glucose metabolic process
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0031670biological_processcellular response to nutrient
B0034614biological_processcellular response to reactive oxygen species
B0042593biological_processglucose homeostasis
B0042803molecular_functionprotein homodimerization activity
B0045254cellular_componentpyruvate dehydrogenase complex
B0050848biological_processregulation of calcium-mediated signaling
B0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue GOL A 401
ChainResidue
APHE39
ASER49
APHE52
ALEU168
AGLN171
AHIS172
AILE175
AHOH528

site_idAC2
Number of Residues3
Detailsbinding site for residue SO4 A 402
ChainResidue
ALYS299
AARG302
AARG298

site_idAC3
Number of Residues4
Detailsbinding site for residue SO4 A 403
ChainResidue
ALYS233
BARG298
BLYS299
BARG302

site_idAC4
Number of Residues4
Detailsbinding site for residue SO4 A 404
ChainResidue
AARG162
AARG166
AASN170
AHOH527

site_idAC5
Number of Residues21
Detailsbinding site for residue EH3 A 405
ChainResidue
ALEU252
AASN255
AARG258
AALA259
AASP290
AGLY294
AVAL295
ALYS299
AARG302
ALEU303
ASER305
ATYR308
AGLY327
ATYR328
AGLY329
ALEU330
APRO331
ALEU346
ATHR354
AHOH540
AHOH556

site_idAC6
Number of Residues5
Detailsbinding site for residue GOL B 401
ChainResidue
BARG157
BLEU371
BPRO372
BVAL373
BASN375

site_idAC7
Number of Residues4
Detailsbinding site for residue GOL B 402
ChainResidue
BPHE39
BSER49
BPHE52
BHOH602

site_idAC8
Number of Residues4
Detailsbinding site for residue SO4 B 403
ChainResidue
BARG166
BASN170
BSER243
BHIS247

site_idAC9
Number of Residues20
Detailsbinding site for residue EH3 B 404
ChainResidue
BLEU252
BASN255
BARG258
BALA259
BASP290
BGLY294
BVAL295
BLYS299
BLEU303
BSER305
BTYR308
BGLY327
BTYR328
BGLY329
BLEU330
BPRO331
BLEU346
BTHR354
BHOH528
BHOH562

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:16401071
ChainResidueDetails
AGLU251
AASP290
AGLY325
BGLU251
BASP290
BGLY325

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ASER309
BSER309

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q15118
ChainResidueDetails
ATYR215
ATYR216
BTYR215
BTYR216

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8BFP9
ChainResidueDetails
ALYS376
BLYS376

225399

PDB entries from 2024-09-25

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