6LGP

cryo-EM structure of TRPV3 in lipid nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue POV A 1001

Chain	Residue
A	LEU517
A	ILE583
A	GLN695
A	PLC1007
A	SER518
A	ASP519
A	TRP521
A	PHE522
A	ALA560
A	ARG567
A	SER576
A	GLN580

---

site_id	AC2
Number of Residues	7
Details	binding site for residue PLC A 1002

Chain	Residue
A	LEU599
A	SER624
A	PHE625
A	SER626
B	TYR460
B	TRP559
D	POV801

---

site_id	AC3
Number of Residues	8
Details	binding site for residue PLC A 1003

Chain	Residue
A	LYS438
A	PHE441
A	TYR565
A	GLY568
A	PHE569
A	GLN570
A	SER571
A	ARG696

---

site_id	AC4
Number of Residues	5
Details	binding site for residue POV A 1004

Chain	Residue
A	SER444
A	LYS500
A	GLU501
A	PHE522
A	HIS523

---

site_id	AC5
Number of Residues	2
Details	binding site for residue POV A 1005

Chain	Residue
A	LEU584
A	PHE592

---

site_id	AC6
Number of Residues	10
Details	binding site for residue POV A 1006

Chain	Residue
A	ILE652
A	LEU655
A	ILE659
A	THR660
A	ILE663
A	PHE666
A	VAL667
B	TYR594
B	LEU630
B	PLC803

---

site_id	AC7
Number of Residues	4
Details	binding site for residue PLC A 1007

Chain	Residue
A	GLU546
A	CYS550
A	POV1001
D	PHE656

---

site_id	AC8
Number of Residues	4
Details	binding site for residue PLC B 801

Chain	Residue
A	PHE656
B	GLU546
B	CYS550
B	POV802

---

site_id	AC9
Number of Residues	12
Details	binding site for residue POV B 802

Chain	Residue
B	LEU517
B	SER518
B	ASP519
B	TRP521
B	PHE522
B	ALA560
B	ARG567
B	SER576
B	GLN580
B	ILE583
B	GLN695
B	PLC801

---

site_id	AD1
Number of Residues	7
Details	binding site for residue PLC B 803

Chain	Residue
A	POV1006
B	LEU599
B	SER624
B	PHE625
B	SER626
C	TYR460
C	TRP559

---

site_id	AD2
Number of Residues	8
Details	binding site for residue PLC B 804

Chain	Residue
B	LYS438
B	PHE441
B	TYR565
B	GLY568
B	PHE569
B	GLN570
B	SER571
B	ARG696

---

site_id	AD3
Number of Residues	5
Details	binding site for residue POV B 805

Chain	Residue
B	SER444
B	LYS500
B	GLU501
B	PHE522
B	HIS523

---

site_id	AD4
Number of Residues	2
Details	binding site for residue POV B 806

Chain	Residue
B	LEU584
B	PHE592

---

site_id	AD5
Number of Residues	10
Details	binding site for residue POV B 807

Chain	Residue
B	ILE652
B	LEU655
B	ILE659
B	THR660
B	ILE663
B	PHE666
B	VAL667
C	TYR594
C	LEU630
C	PLC803

---

site_id	AD6
Number of Residues	4
Details	binding site for residue PLC C 801

Chain	Residue
C	POV802
B	PHE656
C	GLU546
C	CYS550

---

site_id	AD7
Number of Residues	12
Details	binding site for residue POV C 802

Chain	Residue
C	LEU517
C	SER518
C	ASP519
C	TRP521
C	PHE522
C	ALA560
C	ARG567
C	SER576
C	GLN580
C	ILE583
C	GLN695
C	PLC801

---

site_id	AD8
Number of Residues	7
Details	binding site for residue PLC C 803

Chain	Residue
B	POV807
C	LEU599
C	SER624
C	PHE625
C	SER626
D	TYR460
D	TRP559

---

site_id	AD9
Number of Residues	8
Details	binding site for residue PLC C 804

Chain	Residue
C	LYS438
C	PHE441
C	TYR565
C	GLY568
C	PHE569
C	GLN570
C	SER571
C	ARG696

---

site_id	AE1
Number of Residues	5
Details	binding site for residue POV C 805

Chain	Residue
C	SER444
C	LYS500
C	GLU501
C	PHE522
C	HIS523

---

site_id	AE2
Number of Residues	2
Details	binding site for residue POV C 806

Chain	Residue
C	LEU584
C	PHE592

---

site_id	AE3
Number of Residues	10
Details	binding site for residue POV C 807

Chain	Residue
C	ILE652
C	LEU655
C	ILE659
C	THR660
C	ILE663
C	PHE666
C	VAL667
D	TYR594
D	LEU630
D	PLC804

---

site_id	AE4
Number of Residues	10
Details	binding site for residue POV D 801

Chain	Residue
A	TYR594
A	LEU630
A	PLC1002
D	ILE652
D	LEU655
D	ILE659
D	THR660
D	ILE663
D	PHE666
D	VAL667

---

site_id	AE5
Number of Residues	4
Details	binding site for residue PLC D 802

Chain	Residue
C	PHE656
D	GLU546
D	CYS550
D	POV803

---

site_id	AE6
Number of Residues	12
Details	binding site for residue POV D 803

Chain	Residue
D	LEU517
D	SER518
D	ASP519
D	TRP521
D	PHE522
D	ALA560
D	ARG567
D	SER576
D	GLN580
D	ILE583
D	GLN695
D	PLC802

---

site_id	AE7
Number of Residues	7
Details	binding site for residue PLC D 804

Chain	Residue
A	TYR460
A	TRP559
C	POV807
D	LEU599
D	SER624
D	PHE625
D	SER626

---

site_id	AE8
Number of Residues	8
Details	binding site for residue PLC D 805

Chain	Residue
D	LYS438
D	PHE441
D	TYR565
D	GLY568
D	PHE569
D	GLN570
D	SER571
D	ARG696

---

site_id	AE9
Number of Residues	5
Details	binding site for residue POV D 806

Chain	Residue
D	SER444
D	LYS500
D	GLU501
D	PHE522
D	HIS523

---

site_id	AF1
Number of Residues	2
Details	binding site for residue POV D 807

Chain	Residue
D	LEU584
D	PHE592

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	116
Details	Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	48
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	68
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	152
Details	Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	100
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	144
Details	Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	112
Details	Repeat: {"description":"ANK 2","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	116
Details	Repeat: {"description":"ANK 3","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	120
Details	Repeat: {"description":"ANK 4","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	128
Details	Repeat: {"description":"ANK 5","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	88
Details	Repeat: {"description":"ANK 6","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	88
Details	Repeat: {"description":"ANK 7","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---