6LCP
Cryo-EM structure of Dnf1 from Chaetomium thermophilum in the E2P state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005215 | molecular_function | transporter activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005768 | cellular_component | endosome |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006869 | biological_process | lipid transport |
| A | 0006897 | biological_process | endocytosis |
| A | 0007163 | biological_process | establishment or maintenance of cell polarity |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0015914 | biological_process | phospholipid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0045332 | biological_process | phospholipid translocation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070867 | cellular_component | mating projection tip membrane |
| A | 0090554 | molecular_function | phosphatidylcholine floppase activity |
| A | 0090556 | molecular_function | phosphatidylserine floppase activity |
| A | 0099040 | biological_process | ceramide translocation |
| A | 0140326 | molecular_function | ATPase-coupled intramembrane lipid transporter activity |
| A | 0140331 | biological_process | aminophospholipid translocation |
| A | 0140346 | molecular_function | phosphatidylserine flippase activity |
| A | 0140351 | molecular_function | glycosylceramide flippase activity |
| A | 1990531 | cellular_component | phospholipid-translocating ATPase complex |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00154 |
| Number of Residues | 7 |
| Details | ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT |
| Chain | Residue | Details |
| A | ASP606-THR612 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 73 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| B | MET1-LYS48 | |
| B | PHE381-SER407 | |
| A | SER559-MET1123 | |
| A | ASP1168-TYR1200 | |
| A | TYR1259-ASP1262 | |
| A | LYS1324-MET1555 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| B | LEU49-THR69 | |
| A | LEU1303-VAL1323 | |
| B | ILE360-PHE380 | |
| A | VAL492-ILE512 | |
| A | PHE538-ILE558 | |
| A | ILE1124-PHE1144 | |
| A | THR1147-LEU1167 | |
| A | MET1201-LEU1221 | |
| A | LEU1238-THR1258 | |
| A | TRP1263-TYR1283 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 289 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| B | TYR70-GLY359 | |
| A | ALA513-GLY537 | |
| A | GLU1145-TYR1146 | |
| A | THR1222-ARG1237 | |
| A | THR1284-GLU1302 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| B | ASN131 | |
| B | ASN189 | |
| B | ASN219 | |
| B | ASN232 | |
| B | ASN241 | |
| B | ASN314 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9Y2Q0 |
| Chain | Residue | Details |
| A | ASP606 | |
| A | THR608 | |
| A | PHE781 | |
| A | ASP1057 | |
| A | ASN1060 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P32660 |
| Chain | Residue | Details |
| A | LYS607 | |
| A | GLU740 | |
| A | SER783 | |
| A | ARG839 | |
| A | THR840 | |
| A | THR919 | |
| A | ARG1031 | |
| A | LYS1037 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P39524 |
| Chain | Residue | Details |
| A | LYS786 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P04191 |
| Chain | Residue | Details |
| A | LYS804 | |
| A | GLY920 | |
| A | ASP921 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8NB49 |
| Chain | Residue | Details |
| A | ASP1061 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:32303992, ECO:0007744|PDB:6LCP |
| Chain | Residue | Details |
| A | ARG1320 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | SITE: Involved in the release of the transported lipid into the cytosolic leaflet => ECO:0000250|UniProtKB:C7EXK4 |
| Chain | Residue | Details |
| A | ILE554 |
