6L6Z

Cryo-EM structure of the Drosophila CTP synthase substrate-bound filament

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003883	molecular_function	CTP synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0016874	molecular_function	ligase activity
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0035167	biological_process	larval lymph gland hemopoiesis
A	0042802	molecular_function	identical protein binding
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0097268	cellular_component	cytoophidium
B	0000166	molecular_function	nucleotide binding
B	0003883	molecular_function	CTP synthase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0035167	biological_process	larval lymph gland hemopoiesis
B	0042802	molecular_function	identical protein binding
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0097268	cellular_component	cytoophidium
C	0000166	molecular_function	nucleotide binding
C	0003883	molecular_function	CTP synthase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0016874	molecular_function	ligase activity
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0035167	biological_process	larval lymph gland hemopoiesis
C	0042802	molecular_function	identical protein binding
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0097268	cellular_component	cytoophidium
D	0000166	molecular_function	nucleotide binding
D	0003883	molecular_function	CTP synthase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0016874	molecular_function	ligase activity
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0035167	biological_process	larval lymph gland hemopoiesis
D	0042802	molecular_function	identical protein binding
D	0044210	biological_process	'de novo' CTP biosynthetic process
D	0097268	cellular_component	cytoophidium
E	0000166	molecular_function	nucleotide binding
E	0003883	molecular_function	CTP synthase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0016874	molecular_function	ligase activity
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0035167	biological_process	larval lymph gland hemopoiesis
E	0042802	molecular_function	identical protein binding
E	0044210	biological_process	'de novo' CTP biosynthetic process
E	0097268	cellular_component	cytoophidium
F	0000166	molecular_function	nucleotide binding
F	0003883	molecular_function	CTP synthase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006241	biological_process	CTP biosynthetic process
F	0016874	molecular_function	ligase activity
F	0019856	biological_process	pyrimidine nucleobase biosynthetic process
F	0035167	biological_process	larval lymph gland hemopoiesis
F	0042802	molecular_function	identical protein binding
F	0044210	biological_process	'de novo' CTP biosynthetic process
F	0097268	cellular_component	cytoophidium
G	0000166	molecular_function	nucleotide binding
G	0003883	molecular_function	CTP synthase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006241	biological_process	CTP biosynthetic process
G	0016874	molecular_function	ligase activity
G	0019856	biological_process	pyrimidine nucleobase biosynthetic process
G	0035167	biological_process	larval lymph gland hemopoiesis
G	0042802	molecular_function	identical protein binding
G	0044210	biological_process	'de novo' CTP biosynthetic process
G	0097268	cellular_component	cytoophidium
H	0000166	molecular_function	nucleotide binding
H	0003883	molecular_function	CTP synthase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006241	biological_process	CTP biosynthetic process
H	0016874	molecular_function	ligase activity
H	0019856	biological_process	pyrimidine nucleobase biosynthetic process
H	0035167	biological_process	larval lymph gland hemopoiesis
H	0042802	molecular_function	identical protein binding
H	0044210	biological_process	'de novo' CTP biosynthetic process
H	0097268	cellular_component	cytoophidium

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	ACT_SITE: For GATase activity => ECO:0000255|PROSITE-ProRule:PRU00605

Chain	Residue	Details
D	CYS399
C	CYS399
C	HIS526
C	GLU528
H	CYS399
H	HIS526
H	GLU528
E	CYS399
E	HIS526
E	GLU528
F	CYS399
D	HIS526
F	HIS526
F	GLU528
G	CYS399
G	HIS526
G	GLU528
D	GLU528
A	CYS399
A	HIS526
A	GLU528
B	CYS399
B	HIS526
B	GLU528

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