6L48
Structure of the human sterol O-acyltransferase 1 in resting state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008374 | molecular_function | O-acyltransferase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0034736 | molecular_function | cholesterol O-acyltransferase activity |
| A | 0042632 | biological_process | cholesterol homeostasis |
| B | 0008374 | molecular_function | O-acyltransferase activity |
| B | 0016020 | cellular_component | membrane |
| B | 0034736 | molecular_function | cholesterol O-acyltransferase activity |
| B | 0042632 | biological_process | cholesterol homeostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue CLR A 2001 |
| Chain | Residue |
| A | HIS137 |
| B | TRP408 |
| A | THR140 |
| B | LEU133 |
| B | ILE138 |
| B | TYR142 |
| B | PHE145 |
| B | TYR336 |
| B | PHE378 |
| B | PHE382 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue CLR B 2001 |
| Chain | Residue |
| A | LEU133 |
| A | ILE138 |
| A | TYR142 |
| A | PHE145 |
| A | TYR336 |
| A | PHE378 |
| A | PHE382 |
| A | TRP408 |
| B | HIS137 |
| B | THR140 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 94 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 116 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 46 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 64 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 62 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 12 |
| Details | Motif: {"description":"FYXDWWN motif","evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"16154994","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16647063","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32433613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32433614","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6P2J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VUM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
