6L48
Structure of the human sterol O-acyltransferase 1 in resting state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008374 | molecular_function | O-acyltransferase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0034736 | molecular_function | cholesterol O-acyltransferase activity |
| A | 0042632 | biological_process | cholesterol homeostasis |
| B | 0008374 | molecular_function | O-acyltransferase activity |
| B | 0016020 | cellular_component | membrane |
| B | 0034736 | molecular_function | cholesterol O-acyltransferase activity |
| B | 0042632 | biological_process | cholesterol homeostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue CLR A 2001 |
| Chain | Residue |
| A | HIS137 |
| B | TRP408 |
| A | THR140 |
| B | LEU133 |
| B | ILE138 |
| B | TYR142 |
| B | PHE145 |
| B | TYR336 |
| B | PHE378 |
| B | PHE382 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue CLR B 2001 |
| Chain | Residue |
| A | LEU133 |
| A | ILE138 |
| A | TYR142 |
| A | PHE145 |
| A | TYR336 |
| A | PHE378 |
| A | PHE382 |
| A | TRP408 |
| B | HIS137 |
| B | THR140 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM |
| Chain | Residue | Details |
| A | ARG139-ASP160 | |
| B | ARG139-ASP160 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 136 |
| Details | TOPO_DOM: Lumenal => ECO:0000305 |
| Chain | Residue | Details |
| A | TYR161-LYS180 | |
| B | PRO529-PHE550 | |
| A | ALA245-SER252 | |
| A | LYS353-SER369 | |
| A | SER469-VAL474 | |
| A | PRO529-PHE550 | |
| B | TYR161-LYS180 | |
| B | ALA245-SER252 | |
| B | LYS353-SER369 | |
| B | SER469-VAL474 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 50 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM |
| Chain | Residue | Details |
| A | PHE181-TRP206 | |
| B | PHE181-TRP206 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 210 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | ALA207-ILE218 | |
| A | ARG277-ARG319 | |
| A | LEU396-ARG443 | |
| A | ASN491-LYS496 | |
| B | ALA207-ILE218 | |
| B | ARG277-ARG319 | |
| B | LEU396-ARG443 | |
| B | ASN491-LYS496 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 50 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM |
| Chain | Residue | Details |
| A | ARG219-LEU244 | |
| B | ARG219-LEU244 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 46 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM |
| Chain | Residue | Details |
| A | ARG253-PRO276 | |
| B | ARG253-PRO276 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 64 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM |
| Chain | Residue | Details |
| A | TRP320-ILE352 | |
| B | TRP320-ILE352 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 50 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM |
| Chain | Residue | Details |
| A | ILE370-MET395 | |
| B | ILE370-MET395 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM |
| Chain | Residue | Details |
| A | PHE444-LEU468 | |
| B | PHE444-LEU468 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 30 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM |
| Chain | Residue | Details |
| A | LEU475-VAL490 | |
| B | LEU475-VAL490 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 62 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM |
| Chain | Residue | Details |
| A | PRO497-CYS528 | |
| B | PRO497-CYS528 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:16154994, ECO:0000269|PubMed:16647063, ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0007744|PDB:6VUM |
| Chain | Residue | Details |
| A | HIS460 | |
| B | HIS460 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:32433613, ECO:0007744|PDB:6VUM |
| Chain | Residue | Details |
| A | HIS137 | |
| A | ARG418 | |
| A | TYR433 | |
| A | SER456 | |
| B | HIS137 | |
| B | ARG418 | |
| B | TYR433 | |
| B | SER456 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:32433614, ECO:0007744|PDB:6P2P |
| Chain | Residue | Details |
| A | ASN415 | |
| B | ASN415 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:32433614, ECO:0007744|PDB:6P2J |
| Chain | Residue | Details |
| A | ASN421 | |
| B | ASN421 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM |
| Chain | Residue | Details |
| A | HIS425 | |
| A | LYS445 | |
| B | HIS425 | |
| B | LYS445 |
