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6L3U

Human Cx31.3/GJC3 connexin hemichannel in the presence of calcium

Functional Information from GO Data
ChainGOidnamespacecontents
A0005243molecular_functiongap junction channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0005921cellular_componentgap junction
A0005922cellular_componentconnexin complex
A0007154biological_processcell communication
A0007267biological_processcell-cell signaling
A0007605biological_processsensory perception of sound
A0042552biological_processmyelination
A0042802molecular_functionidentical protein binding
A0043209cellular_componentmyelin sheath
A0055085biological_processtransmembrane transport
A0086053biological_processAV node cell to bundle of His cell communication by electrical coupling
A0086077molecular_functiongap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
B0005243molecular_functiongap junction channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005921cellular_componentgap junction
B0005922cellular_componentconnexin complex
B0007154biological_processcell communication
B0007267biological_processcell-cell signaling
B0007605biological_processsensory perception of sound
B0042552biological_processmyelination
B0042802molecular_functionidentical protein binding
B0043209cellular_componentmyelin sheath
B0055085biological_processtransmembrane transport
B0086053biological_processAV node cell to bundle of His cell communication by electrical coupling
B0086077molecular_functiongap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
C0005243molecular_functiongap junction channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0005921cellular_componentgap junction
C0005922cellular_componentconnexin complex
C0007154biological_processcell communication
C0007267biological_processcell-cell signaling
C0007605biological_processsensory perception of sound
C0042552biological_processmyelination
C0042802molecular_functionidentical protein binding
C0043209cellular_componentmyelin sheath
C0055085biological_processtransmembrane transport
C0086053biological_processAV node cell to bundle of His cell communication by electrical coupling
C0086077molecular_functiongap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
D0005243molecular_functiongap junction channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0005921cellular_componentgap junction
D0005922cellular_componentconnexin complex
D0007154biological_processcell communication
D0007267biological_processcell-cell signaling
D0007605biological_processsensory perception of sound
D0042552biological_processmyelination
D0042802molecular_functionidentical protein binding
D0043209cellular_componentmyelin sheath
D0055085biological_processtransmembrane transport
D0086053biological_processAV node cell to bundle of His cell communication by electrical coupling
D0086077molecular_functiongap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
E0005243molecular_functiongap junction channel activity
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0005921cellular_componentgap junction
E0005922cellular_componentconnexin complex
E0007154biological_processcell communication
E0007267biological_processcell-cell signaling
E0007605biological_processsensory perception of sound
E0042552biological_processmyelination
E0042802molecular_functionidentical protein binding
E0043209cellular_componentmyelin sheath
E0055085biological_processtransmembrane transport
E0086053biological_processAV node cell to bundle of His cell communication by electrical coupling
E0086077molecular_functiongap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
F0005243molecular_functiongap junction channel activity
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0005921cellular_componentgap junction
F0005922cellular_componentconnexin complex
F0007154biological_processcell communication
F0007267biological_processcell-cell signaling
F0007605biological_processsensory perception of sound
F0042552biological_processmyelination
F0042802molecular_functionidentical protein binding
F0043209cellular_componentmyelin sheath
F0055085biological_processtransmembrane transport
F0086053biological_processAV node cell to bundle of His cell communication by electrical coupling
F0086077molecular_functiongap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue LMN A 301
ChainResidue
AALA67
APHE79
BSER186

site_idAC2
Number of Residues3
Detailsbinding site for residue CA A 302
ChainResidue
AASP66
AHIS69
BGLU187

site_idAC3
Number of Residues4
Detailsbinding site for residue LMN A 303
ChainResidue
FPHE79
APRO185
ASER186
FALA67

site_idAC4
Number of Residues3
Detailsbinding site for residue LMN B 301
ChainResidue
BALA67
BPHE79
CSER186

site_idAC5
Number of Residues3
Detailsbinding site for residue CA B 302
ChainResidue
BASP66
BHIS69
CGLU187

site_idAC6
Number of Residues3
Detailsbinding site for residue LMN C 301
ChainResidue
CALA67
CPHE79
DSER186

site_idAC7
Number of Residues3
Detailsbinding site for residue CA C 302
ChainResidue
CASP66
CHIS69
DGLU187

site_idAC8
Number of Residues3
Detailsbinding site for residue LMN D 301
ChainResidue
DALA67
DPHE79
ESER186

site_idAC9
Number of Residues3
Detailsbinding site for residue CA D 302
ChainResidue
DASP66
DHIS69
EGLU187

site_idAD1
Number of Residues3
Detailsbinding site for residue LMN E 301
ChainResidue
EALA67
EPHE79
FSER186

site_idAD2
Number of Residues3
Detailsbinding site for residue CA E 302
ChainResidue
EASP66
EHIS69
FGLU187

site_idAD3
Number of Residues3
Detailsbinding site for residue CA F 301
ChainResidue
AGLU187
FASP66
FHIS69

Functional Information from PROSITE/UniProt
site_idPS00407
Number of Residues14
DetailsCONNEXINS_1 Connexins signature 1. CHTqQPGCkaACFD
ChainResidueDetails
ACYS53-ASP66

site_idPS00408
Number of Residues17
DetailsCONNEXINS_2 Connexins signature 2. Crre.PClgsITCNLSRP
ChainResidueDetails
ACYS169-PRO185

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues714
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-ARG22
DMET1-ARG22
DTYR97-ARG132
DGLY216-ALA279
EMET1-ARG22
ETYR97-ARG132
EGLY216-ALA279
FMET1-ARG22
FTYR97-ARG132
FGLY216-ALA279
ATYR97-ARG132
AGLY216-ALA279
BMET1-ARG22
BTYR97-ARG132
BGLY216-ALA279
CMET1-ARG22
CTYR97-ARG132
CGLY216-ALA279

site_idSWS_FT_FI2
Number of Residues480
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU23-VAL43
CPHE76-LEU96
CLEU133-GLY153
CMET195-LEU215
DLEU23-VAL43
DPHE76-LEU96
DLEU133-GLY153
DMET195-LEU215
ELEU23-VAL43
EPHE76-LEU96
ELEU133-GLY153
APHE76-LEU96
EMET195-LEU215
FLEU23-VAL43
FPHE76-LEU96
FLEU133-GLY153
FMET195-LEU215
ALEU133-GLY153
AMET195-LEU215
BLEU23-VAL43
BPHE76-LEU96
BLEU133-GLY153
BMET195-LEU215
CLEU23-VAL43

site_idSWS_FT_FI3
Number of Residues426
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
ATYR44-ARG75
ELEU154-THR194
FTYR44-ARG75
FLEU154-THR194
ALEU154-THR194
BTYR44-ARG75
BLEU154-THR194
CTYR44-ARG75
CLEU154-THR194
DTYR44-ARG75
DLEU154-THR194
ETYR44-ARG75

224931

PDB entries from 2024-09-11

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