Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6L3U

Human Cx31.3/GJC3 connexin hemichannel in the presence of calcium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005243	molecular_function	gap junction channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0005921	cellular_component	gap junction
A	0005922	cellular_component	connexin complex
A	0007154	biological_process	cell communication
A	0007267	biological_process	cell-cell signaling
A	0042802	molecular_function	identical protein binding
A	0043209	cellular_component	myelin sheath
A	0055085	biological_process	transmembrane transport
A	0086053	biological_process	AV node cell to bundle of His cell communication by electrical coupling
A	0086077	molecular_function	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
B	0005243	molecular_function	gap junction channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0005921	cellular_component	gap junction
B	0005922	cellular_component	connexin complex
B	0007154	biological_process	cell communication
B	0007267	biological_process	cell-cell signaling
B	0042802	molecular_function	identical protein binding
B	0043209	cellular_component	myelin sheath
B	0055085	biological_process	transmembrane transport
B	0086053	biological_process	AV node cell to bundle of His cell communication by electrical coupling
B	0086077	molecular_function	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
C	0005243	molecular_function	gap junction channel activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0005921	cellular_component	gap junction
C	0005922	cellular_component	connexin complex
C	0007154	biological_process	cell communication
C	0007267	biological_process	cell-cell signaling
C	0042802	molecular_function	identical protein binding
C	0043209	cellular_component	myelin sheath
C	0055085	biological_process	transmembrane transport
C	0086053	biological_process	AV node cell to bundle of His cell communication by electrical coupling
C	0086077	molecular_function	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
D	0005243	molecular_function	gap junction channel activity
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0005921	cellular_component	gap junction
D	0005922	cellular_component	connexin complex
D	0007154	biological_process	cell communication
D	0007267	biological_process	cell-cell signaling
D	0042802	molecular_function	identical protein binding
D	0043209	cellular_component	myelin sheath
D	0055085	biological_process	transmembrane transport
D	0086053	biological_process	AV node cell to bundle of His cell communication by electrical coupling
D	0086077	molecular_function	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
E	0005243	molecular_function	gap junction channel activity
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0005921	cellular_component	gap junction
E	0005922	cellular_component	connexin complex
E	0007154	biological_process	cell communication
E	0007267	biological_process	cell-cell signaling
E	0042802	molecular_function	identical protein binding
E	0043209	cellular_component	myelin sheath
E	0055085	biological_process	transmembrane transport
E	0086053	biological_process	AV node cell to bundle of His cell communication by electrical coupling
E	0086077	molecular_function	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
F	0005243	molecular_function	gap junction channel activity
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0005921	cellular_component	gap junction
F	0005922	cellular_component	connexin complex
F	0007154	biological_process	cell communication
F	0007267	biological_process	cell-cell signaling
F	0042802	molecular_function	identical protein binding
F	0043209	cellular_component	myelin sheath
F	0055085	biological_process	transmembrane transport
F	0086053	biological_process	AV node cell to bundle of His cell communication by electrical coupling
F	0086077	molecular_function	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue LMN A 301

Chain	Residue
A	ALA67
A	PHE79
B	SER186

site_id	AC2
Number of Residues	3
Details	binding site for residue CA A 302

Chain	Residue
A	ASP66
A	HIS69
B	GLU187

site_id	AC3
Number of Residues	4
Details	binding site for residue LMN A 303

Chain	Residue
F	PHE79
A	PRO185
A	SER186
F	ALA67

site_id	AC4
Number of Residues	3
Details	binding site for residue LMN B 301

Chain	Residue
B	ALA67
B	PHE79
C	SER186

site_id	AC5
Number of Residues	3
Details	binding site for residue CA B 302

Chain	Residue
B	ASP66
B	HIS69
C	GLU187

site_id	AC6
Number of Residues	3
Details	binding site for residue LMN C 301

Chain	Residue
C	ALA67
C	PHE79
D	SER186

site_id	AC7
Number of Residues	3
Details	binding site for residue CA C 302

Chain	Residue
C	ASP66
C	HIS69
D	GLU187

site_id	AC8
Number of Residues	3
Details	binding site for residue LMN D 301

Chain	Residue
D	ALA67
D	PHE79
E	SER186

site_id	AC9
Number of Residues	3
Details	binding site for residue CA D 302

Chain	Residue
D	ASP66
D	HIS69
E	GLU187

site_id	AD1
Number of Residues	3
Details	binding site for residue LMN E 301

Chain	Residue
E	ALA67
E	PHE79
F	SER186

site_id	AD2
Number of Residues	3
Details	binding site for residue CA E 302

Chain	Residue
E	ASP66
E	HIS69
F	GLU187

site_id	AD3
Number of Residues	3
Details	binding site for residue CA F 301

Chain	Residue
A	GLU187
F	ASP66
F	HIS69

Functional Information from PROSITE/UniProt

site_id	PS00407
Number of Residues	14
Details	CONNEXINS_1 Connexins signature 1. CHTqQPGCkaACFD

Chain	Residue	Details
A	CYS53-ASP66

site_id	PS00408
Number of Residues	17
Details	CONNEXINS_2 Connexins signature 2. Crre.PClgsITCNLSRP

Chain	Residue	Details
A	CYS169-PRO185

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	480
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	426
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)