6L30
Crystal structure of the epithelial cell transforming 2 (ECT2)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0043547 | biological_process | positive regulation of GTPase activity |
| A | 2000431 | biological_process | regulation of cytokinesis, actomyosin contractile ring assembly |
Functional Information from PROSITE/UniProt
| site_id | PS00741 |
| Number of Residues | 26 |
| Details | DH_1 Dbl homology (DH) domain signature. LveLLirPVqrLpSvaLlLnDLkkhT |
| Chain | Residue | Details |
| A | LEU558-THR583 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKC/PRKCI => ECO:0000269|PubMed:21189248, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR328 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER336 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER345 | |
| A | SER811 | |
| A | SER339 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:16170345, ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | THR342 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:16247472 |
| Chain | Residue | Details |
| A | THR413 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER685 | |
| A | SER830 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by CDK1 => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | THR815 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS580 |
