6L2G
Crystal structure of Aspergillus fumigatus mitochondrial acetyl-CoA acetyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0003988 | molecular_function | acetyl-CoA C-acyltransferase activity |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00098 |
| Number of Residues | 19 |
| Details | THIOLASE_1 Thiolases acyl-enzyme intermediate signature. VNKvCASGLkAValaaqnI |
| Chain | Residue | Details |
| A | VAL120-ILE138 |
| site_id | PS00099 |
| Number of Residues | 14 |
| Details | THIOLASE_3 Thiolases active site. GVAAICNGgGaAtA |
| Chain | Residue | Details |
| A | GLY410-ALA423 |
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. FAQGNRALARIVSTA |
| Chain | Residue | Details |
| A | PHE304-ALA318 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Acyl-thioester intermediate => ECO:0000250|UniProtKB:P24752 |
| Chain | Residue | Details |
| A | SCY124 | |
| B | SCY124 | |
| C | SCY124 | |
| D | SCY124 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10020 |
| Chain | Residue | Details |
| A | HIS387 | |
| A | CYS415 | |
| B | HIS387 | |
| B | CYS415 | |
| C | HIS387 | |
| C | CYS415 | |
| D | HIS387 | |
| D | CYS415 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q4WCL5 |
| Chain | Residue | Details |
| A | TYR219 | |
| B | ASN416 | |
| C | TYR219 | |
| C | LYS262 | |
| C | ALA280 | |
| C | SER284 | |
| C | ASN416 | |
| D | TYR219 | |
| D | LYS262 | |
| D | ALA280 | |
| D | SER284 | |
| A | LYS262 | |
| D | ASN416 | |
| A | ALA280 | |
| A | SER284 | |
| A | ASN416 | |
| B | TYR219 | |
| B | LYS262 | |
| B | ALA280 | |
| B | SER284 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:32005728, ECO:0007744|PDB:6L2C |
| Chain | Residue | Details |
| A | ASN229 | |
| B | ASN229 | |
| C | ASN229 | |
| D | ASN229 |
