6L2G

Crystal structure of Aspergillus fumigatus mitochondrial acetyl-CoA acetyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
A	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
A	0005739	cellular_component	mitochondrion
A	0006635	biological_process	fatty acid beta-oxidation
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0046872	molecular_function	metal ion binding
B	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
B	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
B	0005739	cellular_component	mitochondrion
B	0006635	biological_process	fatty acid beta-oxidation
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0046872	molecular_function	metal ion binding
C	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
C	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
C	0005739	cellular_component	mitochondrion
C	0006635	biological_process	fatty acid beta-oxidation
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0046872	molecular_function	metal ion binding
D	0003985	molecular_function	acetyl-CoA C-acetyltransferase activity
D	0003988	molecular_function	acetyl-CoA C-acyltransferase activity
D	0005739	cellular_component	mitochondrion
D	0006635	biological_process	fatty acid beta-oxidation
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00098
Number of Residues	19
Details	THIOLASE_1 Thiolases acyl-enzyme intermediate signature. VNKvCASGLkAValaaqnI

Chain	Residue	Details
A	VAL120-ILE138

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site_id	PS00099
Number of Residues	14
Details	THIOLASE_3 Thiolases active site. GVAAICNGgGaAtA

Chain	Residue	Details
A	GLY410-ALA423

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site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. FAQGNRALARIVSTA

Chain	Residue	Details
A	PHE304-ALA318

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Acyl-thioester intermediate => ECO:0000250|UniProtKB:P24752

Chain	Residue	Details
A	SCY124
B	SCY124
C	SCY124
D	SCY124

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site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10020

Chain	Residue	Details
A	HIS387
A	CYS415
B	HIS387
B	CYS415
C	HIS387
C	CYS415
D	HIS387
D	CYS415

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site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q4WCL5

Chain	Residue	Details
A	TYR219
B	ASN416
C	TYR219
C	LYS262
C	ALA280
C	SER284
C	ASN416
D	TYR219
D	LYS262
D	ALA280
D	SER284
A	LYS262
D	ASN416
A	ALA280
A	SER284
A	ASN416
B	TYR219
B	LYS262
B	ALA280
B	SER284

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:32005728, ECO:0007744|PDB:6L2C

Chain	Residue	Details
A	ASN229
B	ASN229
C	ASN229
D	ASN229

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