6L20

Crystal structure of CK2a2 with hematein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000785	cellular_component	chromatin
A	0001669	cellular_component	acrosomal vesicle
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005956	cellular_component	protein kinase CK2 complex
A	0006302	biological_process	double-strand break repair
A	0006351	biological_process	DNA-templated transcription
A	0006468	biological_process	protein phosphorylation
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0007283	biological_process	spermatogenesis
A	0016055	biological_process	Wnt signaling pathway
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0021987	biological_process	cerebral cortex development
A	0031507	biological_process	heterochromatin formation
A	0031519	cellular_component	PcG protein complex
A	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0042176	biological_process	regulation of protein catabolic process
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0097421	biological_process	liver regeneration
A	0106310	molecular_function	protein serine kinase activity
A	1901524	biological_process	regulation of mitophagy
A	1903955	biological_process	positive regulation of protein targeting to mitochondrion
A	1905818	biological_process	regulation of chromosome separation
A	2001234	biological_process	negative regulation of apoptotic signaling pathway
D	0000166	molecular_function	nucleotide binding
D	0000785	cellular_component	chromatin
D	0001669	cellular_component	acrosomal vesicle
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005956	cellular_component	protein kinase CK2 complex
D	0006302	biological_process	double-strand break repair
D	0006351	biological_process	DNA-templated transcription
D	0006468	biological_process	protein phosphorylation
D	0006915	biological_process	apoptotic process
D	0006974	biological_process	DNA damage response
D	0007283	biological_process	spermatogenesis
D	0016055	biological_process	Wnt signaling pathway
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0021987	biological_process	cerebral cortex development
D	0031507	biological_process	heterochromatin formation
D	0031519	cellular_component	PcG protein complex
D	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0042176	biological_process	regulation of protein catabolic process
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0097421	biological_process	liver regeneration
D	0106310	molecular_function	protein serine kinase activity
D	1901524	biological_process	regulation of mitophagy
D	1903955	biological_process	positive regulation of protein targeting to mitochondrion
D	1905818	biological_process	regulation of chromosome separation
D	2001234	biological_process	negative regulation of apoptotic signaling pathway
G	0000166	molecular_function	nucleotide binding
G	0000785	cellular_component	chromatin
G	0001669	cellular_component	acrosomal vesicle
G	0004672	molecular_function	protein kinase activity
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005956	cellular_component	protein kinase CK2 complex
G	0006302	biological_process	double-strand break repair
G	0006351	biological_process	DNA-templated transcription
G	0006468	biological_process	protein phosphorylation
G	0006915	biological_process	apoptotic process
G	0006974	biological_process	DNA damage response
G	0007283	biological_process	spermatogenesis
G	0016055	biological_process	Wnt signaling pathway
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0021987	biological_process	cerebral cortex development
G	0031507	biological_process	heterochromatin formation
G	0031519	cellular_component	PcG protein complex
G	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
G	0042176	biological_process	regulation of protein catabolic process
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0097421	biological_process	liver regeneration
G	0106310	molecular_function	protein serine kinase activity
G	1901524	biological_process	regulation of mitophagy
G	1903955	biological_process	positive regulation of protein targeting to mitochondrion
G	1905818	biological_process	regulation of chromosome separation
G	2001234	biological_process	negative regulation of apoptotic signaling pathway
J	0000166	molecular_function	nucleotide binding
J	0000785	cellular_component	chromatin
J	0001669	cellular_component	acrosomal vesicle
J	0004672	molecular_function	protein kinase activity
J	0004674	molecular_function	protein serine/threonine kinase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005956	cellular_component	protein kinase CK2 complex
J	0006302	biological_process	double-strand break repair
J	0006351	biological_process	DNA-templated transcription
J	0006468	biological_process	protein phosphorylation
J	0006915	biological_process	apoptotic process
J	0006974	biological_process	DNA damage response
J	0007283	biological_process	spermatogenesis
J	0016055	biological_process	Wnt signaling pathway
J	0016301	molecular_function	kinase activity
J	0016740	molecular_function	transferase activity
J	0021987	biological_process	cerebral cortex development
J	0031507	biological_process	heterochromatin formation
J	0031519	cellular_component	PcG protein complex
J	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
J	0042176	biological_process	regulation of protein catabolic process
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0097421	biological_process	liver regeneration
J	0106310	molecular_function	protein serine kinase activity
J	1901524	biological_process	regulation of mitophagy
J	1903955	biological_process	positive regulation of protein targeting to mitochondrion
J	1905818	biological_process	regulation of chromosome separation
J	2001234	biological_process	negative regulation of apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue E3U A 401

Chain	Residue
A	LEU46
A	MET164
A	ILE175
A	ASP176
A	VAL54
A	VAL67
A	LYS69
A	PHE114
A	GLU115
A	TYR116
A	ILE117
A	ASN119

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CL A 402

Chain	Residue
A	ARG81
A	ARG156

---

site_id	AC3
Number of Residues	10
Details	binding site for residue E3U D 401

Chain	Residue
D	VAL54
D	VAL67
D	LYS69
D	GLU82
D	ILE96
D	PHE114
D	TYR116
D	ILE117
D	ILE175
D	ASP176

---

site_id	AC4
Number of Residues	2
Details	binding site for residue CL D 402

Chain	Residue
D	ARG156
D	ASN190

---

site_id	AC5
Number of Residues	12
Details	binding site for residue E3U G 401

Chain	Residue
G	VAL54
G	VAL67
G	LYS69
G	GLU82
G	ILE96
G	PHE114
G	GLU115
G	TYR116
G	ILE117
G	MET164
G	ILE175
G	ASP176

---

site_id	AC6
Number of Residues	11
Details	binding site for residue E3U J 401

Chain	Residue
J	VAL54
J	LYS69
J	GLU82
J	PHE114
J	GLU115
J	TYR116
J	ILE117
J	MET164
J	ILE175
J	ASP176
J	TRP177

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnner..........VVVK

Chain	Residue	Details
A	LEU46-LYS69

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI

Chain	Residue	Details
A	ILE153-ILE165

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---