6L20

Crystal structure of CK2a2 with hematein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000785	cellular_component	chromatin
A	0001669	cellular_component	acrosomal vesicle
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005956	cellular_component	protein kinase CK2 complex
A	0006302	biological_process	double-strand break repair
A	0006468	biological_process	protein phosphorylation
A	0006915	biological_process	apoptotic process
A	0007049	biological_process	cell cycle
A	0007283	biological_process	spermatogenesis
A	0016055	biological_process	Wnt signaling pathway
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016740	molecular_function	transferase activity
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0021987	biological_process	cerebral cortex development
A	0031519	cellular_component	PcG protein complex
A	0051726	biological_process	regulation of cell cycle
A	0097421	biological_process	liver regeneration
A	0106310	molecular_function	protein serine kinase activity
A	1901524	biological_process	regulation of mitophagy
A	1903955	biological_process	positive regulation of protein targeting to mitochondrion
A	1905818	biological_process	regulation of chromosome separation
A	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
A	2001234	biological_process	negative regulation of apoptotic signaling pathway
D	0000166	molecular_function	nucleotide binding
D	0000785	cellular_component	chromatin
D	0001669	cellular_component	acrosomal vesicle
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005956	cellular_component	protein kinase CK2 complex
D	0006302	biological_process	double-strand break repair
D	0006468	biological_process	protein phosphorylation
D	0006915	biological_process	apoptotic process
D	0007049	biological_process	cell cycle
D	0007283	biological_process	spermatogenesis
D	0016055	biological_process	Wnt signaling pathway
D	0016301	molecular_function	kinase activity
D	0016310	biological_process	phosphorylation
D	0016740	molecular_function	transferase activity
D	0018105	biological_process	peptidyl-serine phosphorylation
D	0021987	biological_process	cerebral cortex development
D	0031519	cellular_component	PcG protein complex
D	0051726	biological_process	regulation of cell cycle
D	0097421	biological_process	liver regeneration
D	0106310	molecular_function	protein serine kinase activity
D	1901524	biological_process	regulation of mitophagy
D	1903955	biological_process	positive regulation of protein targeting to mitochondrion
D	1905818	biological_process	regulation of chromosome separation
D	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
D	2001234	biological_process	negative regulation of apoptotic signaling pathway
G	0000166	molecular_function	nucleotide binding
G	0000785	cellular_component	chromatin
G	0001669	cellular_component	acrosomal vesicle
G	0004672	molecular_function	protein kinase activity
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005956	cellular_component	protein kinase CK2 complex
G	0006302	biological_process	double-strand break repair
G	0006468	biological_process	protein phosphorylation
G	0006915	biological_process	apoptotic process
G	0007049	biological_process	cell cycle
G	0007283	biological_process	spermatogenesis
G	0016055	biological_process	Wnt signaling pathway
G	0016301	molecular_function	kinase activity
G	0016310	biological_process	phosphorylation
G	0016740	molecular_function	transferase activity
G	0018105	biological_process	peptidyl-serine phosphorylation
G	0021987	biological_process	cerebral cortex development
G	0031519	cellular_component	PcG protein complex
G	0051726	biological_process	regulation of cell cycle
G	0097421	biological_process	liver regeneration
G	0106310	molecular_function	protein serine kinase activity
G	1901524	biological_process	regulation of mitophagy
G	1903955	biological_process	positive regulation of protein targeting to mitochondrion
G	1905818	biological_process	regulation of chromosome separation
G	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
G	2001234	biological_process	negative regulation of apoptotic signaling pathway
J	0000166	molecular_function	nucleotide binding
J	0000785	cellular_component	chromatin
J	0001669	cellular_component	acrosomal vesicle
J	0004672	molecular_function	protein kinase activity
J	0004674	molecular_function	protein serine/threonine kinase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005956	cellular_component	protein kinase CK2 complex
J	0006302	biological_process	double-strand break repair
J	0006468	biological_process	protein phosphorylation
J	0006915	biological_process	apoptotic process
J	0007049	biological_process	cell cycle
J	0007283	biological_process	spermatogenesis
J	0016055	biological_process	Wnt signaling pathway
J	0016301	molecular_function	kinase activity
J	0016310	biological_process	phosphorylation
J	0016740	molecular_function	transferase activity
J	0018105	biological_process	peptidyl-serine phosphorylation
J	0021987	biological_process	cerebral cortex development
J	0031519	cellular_component	PcG protein complex
J	0051726	biological_process	regulation of cell cycle
J	0097421	biological_process	liver regeneration
J	0106310	molecular_function	protein serine kinase activity
J	1901524	biological_process	regulation of mitophagy
J	1903955	biological_process	positive regulation of protein targeting to mitochondrion
J	1905818	biological_process	regulation of chromosome separation
J	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
J	2001234	biological_process	negative regulation of apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue E3U A 401

Chain	Residue
A	LEU46
A	MET164
A	ILE175
A	ASP176
A	VAL54
A	VAL67
A	LYS69
A	PHE114
A	GLU115
A	TYR116
A	ILE117
A	ASN119

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CL A 402

Chain	Residue
A	ARG81
A	ARG156

---

site_id	AC3
Number of Residues	10
Details	binding site for residue E3U D 401

Chain	Residue
D	VAL54
D	VAL67
D	LYS69
D	GLU82
D	ILE96
D	PHE114
D	TYR116
D	ILE117
D	ILE175
D	ASP176

---

site_id	AC4
Number of Residues	2
Details	binding site for residue CL D 402

Chain	Residue
D	ARG156
D	ASN190

---

site_id	AC5
Number of Residues	12
Details	binding site for residue E3U G 401

Chain	Residue
G	VAL54
G	VAL67
G	LYS69
G	GLU82
G	ILE96
G	PHE114
G	GLU115
G	TYR116
G	ILE117
G	MET164
G	ILE175
G	ASP176

---

site_id	AC6
Number of Residues	11
Details	binding site for residue E3U J 401

Chain	Residue
J	VAL54
J	LYS69
J	GLU82
J	PHE114
J	GLU115
J	TYR116
J	ILE117
J	MET164
J	ILE175
J	ASP176
J	TRP177

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnner..........VVVK

Chain	Residue	Details
A	LEU46-LYS69

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI

Chain	Residue	Details
A	ILE153-ILE165

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP157
D	ASP157
G	ASP157
J	ASP157

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU46
A	LYS69
D	LEU46
D	LYS69
G	LEU46
G	LYS69
J	LEU46
J	LYS69

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	TYR13
D	TYR13
G	TYR13
J	TYR13

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER18
D	SER18
G	SER18
J	SER18

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	SER21
A	SER288
D	SER21
D	SER288
G	SER21
G	SER288
J	SER21
J	SER288

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS97
D	LYS97
G	LYS97
J	LYS97

---