6KXW
Crystal structure of human aquaporin AQP7 in bound to glycerol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005811 | cellular_component | lipid droplet |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005911 | cellular_component | cell-cell junction |
| A | 0006833 | biological_process | water transport |
| A | 0015204 | molecular_function | urea transmembrane transporter activity |
| A | 0015250 | molecular_function | water channel activity |
| A | 0015254 | molecular_function | glycerol channel activity |
| A | 0015267 | molecular_function | channel activity |
| A | 0015793 | biological_process | glycerol transmembrane transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071918 | biological_process | urea transmembrane transport |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005811 | cellular_component | lipid droplet |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005911 | cellular_component | cell-cell junction |
| B | 0006833 | biological_process | water transport |
| B | 0015204 | molecular_function | urea transmembrane transporter activity |
| B | 0015250 | molecular_function | water channel activity |
| B | 0015254 | molecular_function | glycerol channel activity |
| B | 0015267 | molecular_function | channel activity |
| B | 0015793 | biological_process | glycerol transmembrane transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0071918 | biological_process | urea transmembrane transport |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005811 | cellular_component | lipid droplet |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0005911 | cellular_component | cell-cell junction |
| C | 0006833 | biological_process | water transport |
| C | 0015204 | molecular_function | urea transmembrane transporter activity |
| C | 0015250 | molecular_function | water channel activity |
| C | 0015254 | molecular_function | glycerol channel activity |
| C | 0015267 | molecular_function | channel activity |
| C | 0015793 | biological_process | glycerol transmembrane transport |
| C | 0016020 | cellular_component | membrane |
| C | 0016323 | cellular_component | basolateral plasma membrane |
| C | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| C | 0031410 | cellular_component | cytoplasmic vesicle |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0071918 | biological_process | urea transmembrane transport |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005811 | cellular_component | lipid droplet |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0005911 | cellular_component | cell-cell junction |
| D | 0006833 | biological_process | water transport |
| D | 0015204 | molecular_function | urea transmembrane transporter activity |
| D | 0015250 | molecular_function | water channel activity |
| D | 0015254 | molecular_function | glycerol channel activity |
| D | 0015267 | molecular_function | channel activity |
| D | 0015793 | biological_process | glycerol transmembrane transport |
| D | 0016020 | cellular_component | membrane |
| D | 0016323 | cellular_component | basolateral plasma membrane |
| D | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| D | 0031410 | cellular_component | cytoplasmic vesicle |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0071918 | biological_process | urea transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 401 |
| Chain | Residue |
| A | THR160 |
| A | TYR161 |
| A | PRO163 |
| A | ASN220 |
| A | GLY222 |
| D | TYR64 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 400 |
| Chain | Residue |
| C | ARG229 |
| C | TYR67 |
| C | VAL70 |
| C | GLY222 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 68 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 276 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 68 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 84 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 104 |
| Details | Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 68 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 64 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 84 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AMW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8AMX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | Motif: {"description":"NPA 1","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | Motif: {"description":"NPA 2","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 12 |
| Details | Site: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"36737436","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Site: {"description":"Important for permeability to glycerol","evidences":[{"source":"PubMed","id":"30423801","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
