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6KW5

The ClassC RSC-Nucleosome Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000785cellular_componentchromatin
A0003674molecular_functionmolecular_function
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0006325biological_processchromatin organization
A0006337biological_processnucleosome disassembly
A0006338biological_processchromatin remodeling
A0006357biological_processregulation of transcription by RNA polymerase II
A0006368biological_processtranscription elongation by RNA polymerase II
A0016586cellular_componentRSC-type complex
C0000785cellular_componentchromatin
C0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
C0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
C0003677molecular_functionDNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0006303biological_processdouble-strand break repair via nonhomologous end joining
C0006325biological_processchromatin organization
C0006337biological_processnucleosome disassembly
C0006338biological_processchromatin remodeling
C0006355biological_processregulation of DNA-templated transcription
C0006368biological_processtranscription elongation by RNA polymerase II
C0008270molecular_functionzinc ion binding
C0016586cellular_componentRSC-type complex
C0043565molecular_functionsequence-specific DNA binding
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046872molecular_functionmetal ion binding
D0000785cellular_componentchromatin
D0003677molecular_functionDNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0006303biological_processdouble-strand break repair via nonhomologous end joining
D0006325biological_processchromatin organization
D0006337biological_processnucleosome disassembly
D0006338biological_processchromatin remodeling
D0006355biological_processregulation of DNA-templated transcription
D0006368biological_processtranscription elongation by RNA polymerase II
D0008270molecular_functionzinc ion binding
D0016514cellular_componentSWI/SNF complex
D0016586cellular_componentRSC-type complex
D0042393molecular_functionhistone binding
D0045893biological_processpositive regulation of DNA-templated transcription
D0046872molecular_functionmetal ion binding
E0000086biological_processG2/M transition of mitotic cell cycle
E0000785cellular_componentchromatin
E0003682molecular_functionchromatin binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0006337biological_processnucleosome disassembly
E0006338biological_processchromatin remodeling
E0006368biological_processtranscription elongation by RNA polymerase II
E0016586cellular_componentRSC-type complex
f0000785cellular_componentchromatin
f0003674molecular_functionmolecular_function
f0003682molecular_functionchromatin binding
f0005198molecular_functionstructural molecule activity
f0005515molecular_functionprotein binding
f0005634cellular_componentnucleus
f0006325biological_processchromatin organization
f0006337biological_processnucleosome disassembly
f0006338biological_processchromatin remodeling
f0006355biological_processregulation of DNA-templated transcription
f0006357biological_processregulation of transcription by RNA polymerase II
f0006368biological_processtranscription elongation by RNA polymerase II
f0016514cellular_componentSWI/SNF complex
f0016586cellular_componentRSC-type complex
f0035267cellular_componentNuA4 histone acetyltransferase complex
f0043232cellular_componentintracellular non-membrane-bounded organelle
f0045944biological_processpositive regulation of transcription by RNA polymerase II
F0000785cellular_componentchromatin
F0003674molecular_functionmolecular_function
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0006325biological_processchromatin organization
F0006337biological_processnucleosome disassembly
F0006338biological_processchromatin remodeling
F0006368biological_processtranscription elongation by RNA polymerase II
F0016586cellular_componentRSC-type complex
F0031490molecular_functionchromatin DNA binding
g0000785cellular_componentchromatin
g0005198molecular_functionstructural molecule activity
g0005515molecular_functionprotein binding
g0005634cellular_componentnucleus
g0006325biological_processchromatin organization
g0006337biological_processnucleosome disassembly
g0006338biological_processchromatin remodeling
g0006355biological_processregulation of DNA-templated transcription
g0006357biological_processregulation of transcription by RNA polymerase II
g0006368biological_processtranscription elongation by RNA polymerase II
g0016514cellular_componentSWI/SNF complex
g0016586cellular_componentRSC-type complex
g0043232cellular_componentintracellular non-membrane-bounded organelle
g0045944biological_processpositive regulation of transcription by RNA polymerase II
G0000086biological_processG2/M transition of mitotic cell cycle
G0000228cellular_componentnuclear chromosome
G0000785cellular_componentchromatin
G0003712molecular_functiontranscription coregulator activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0006302biological_processdouble-strand break repair
G0006325biological_processchromatin organization
G0006337biological_processnucleosome disassembly
G0006338biological_processchromatin remodeling
G0006357biological_processregulation of transcription by RNA polymerase II
G0006368biological_processtranscription elongation by RNA polymerase II
G0007059biological_processchromosome segregation
G0016586cellular_componentRSC-type complex
G0031055biological_processchromatin remodeling at centromere
G0031491molecular_functionnucleosome binding
G0033262biological_processregulation of nuclear cell cycle DNA replication
h0000785cellular_componentchromatin
h0005515molecular_functionprotein binding
h0005634cellular_componentnucleus
h0006337biological_processnucleosome disassembly
h0006338biological_processchromatin remodeling
h0006357biological_processregulation of transcription by RNA polymerase II
h0006368biological_processtranscription elongation by RNA polymerase II
h0007059biological_processchromosome segregation
h0015616molecular_functionDNA translocase activity
h0016514cellular_componentSWI/SNF complex
h0016586cellular_componentRSC-type complex
H0000785cellular_componentchromatin
H0003677molecular_functionDNA binding
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0006303biological_processdouble-strand break repair via nonhomologous end joining
H0006325biological_processchromatin organization
H0006337biological_processnucleosome disassembly
H0006338biological_processchromatin remodeling
H0006355biological_processregulation of DNA-templated transcription
H0006368biological_processtranscription elongation by RNA polymerase II
H0008270molecular_functionzinc ion binding
H0016514cellular_componentSWI/SNF complex
H0016586cellular_componentRSC-type complex
H0042393molecular_functionhistone binding
H0045893biological_processpositive regulation of DNA-templated transcription
H0046872molecular_functionmetal ion binding
I0000785cellular_componentchromatin
I0005198molecular_functionstructural molecule activity
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0006325biological_processchromatin organization
I0006337biological_processnucleosome disassembly
I0006338biological_processchromatin remodeling
I0006357biological_processregulation of transcription by RNA polymerase II
I0016514cellular_componentSWI/SNF complex
I0016586cellular_componentRSC-type complex
I0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
J0000775cellular_componentchromosome, centromeric region
J0000785cellular_componentchromatin
J0003677molecular_functionDNA binding
J0004386molecular_functionhelicase activity
J0005515molecular_functionprotein binding
J0005524molecular_functionATP binding
J0005634cellular_componentnucleus
J0006284biological_processbase-excision repair
J0006302biological_processdouble-strand break repair
J0006325biological_processchromatin organization
J0006337biological_processnucleosome disassembly
J0006338biological_processchromatin remodeling
J0006355biological_processregulation of DNA-templated transcription
J0006368biological_processtranscription elongation by RNA polymerase II
J0007010biological_processcytoskeleton organization
J0007059biological_processchromosome segregation
J0008094molecular_functionATP-dependent activity, acting on DNA
J0015616molecular_functionDNA translocase activity
J0016586cellular_componentRSC-type complex
J0016787molecular_functionhydrolase activity
J0016887molecular_functionATP hydrolysis activity
J0031055biological_processchromatin remodeling at centromere
J0042393molecular_functionhistone binding
J0045944biological_processpositive regulation of transcription by RNA polymerase II
J0051321biological_processmeiotic cell cycle
J0070577molecular_functionlysine-acetylated histone binding
J0140566molecular_functionhistone reader activity
J0140658molecular_functionATP-dependent chromatin remodeler activity
K0000785cellular_componentchromatin
K0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
K0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
K0003677molecular_functionDNA binding
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0006325biological_processchromatin organization
K0006337biological_processnucleosome disassembly
K0006338biological_processchromatin remodeling
K0006355biological_processregulation of DNA-templated transcription
K0006368biological_processtranscription elongation by RNA polymerase II
K0008270molecular_functionzinc ion binding
K0016586cellular_componentRSC-type complex
K0033262biological_processregulation of nuclear cell cycle DNA replication
K0043565molecular_functionsequence-specific DNA binding
K0045944biological_processpositive regulation of transcription by RNA polymerase II
K0046872molecular_functionmetal ion binding
L0000724biological_processdouble-strand break repair via homologous recombination
L0003682molecular_functionchromatin binding
L0005634cellular_componentnucleus
L0006276biological_processplasmid maintenance
L0006303biological_processdouble-strand break repair via nonhomologous end joining
L0006325biological_processchromatin organization
L0006337biological_processnucleosome disassembly
L0006338biological_processchromatin remodeling
L0006366biological_processtranscription by RNA polymerase II
L0006368biological_processtranscription elongation by RNA polymerase II
L0007059biological_processchromosome segregation
L0007062biological_processsister chromatid cohesion
L0016586cellular_componentRSC-type complex
L0030435biological_processsporulation resulting in formation of a cellular spore
L0042173biological_processregulation of sporulation resulting in formation of a cellular spore
L0070914biological_processUV-damage excision repair
M0000785cellular_componentchromatin
M0003677molecular_functionDNA binding
M0005634cellular_componentnucleus
M0006325biological_processchromatin organization
M0006337biological_processnucleosome disassembly
M0006338biological_processchromatin remodeling
M0006355biological_processregulation of DNA-templated transcription
M0006357biological_processregulation of transcription by RNA polymerase II
M0006368biological_processtranscription elongation by RNA polymerase II
M0009303biological_processrRNA transcription
M0016586cellular_componentRSC-type complex
O0000786cellular_componentnucleosome
O0003677molecular_functionDNA binding
O0005634cellular_componentnucleus
O0005694cellular_componentchromosome
O0030527molecular_functionstructural constituent of chromatin
O0046982molecular_functionprotein heterodimerization activity
P0000775cellular_componentchromosome, centromeric region
P0000785cellular_componentchromatin
P0003677molecular_functionDNA binding
P0004386molecular_functionhelicase activity
P0005515molecular_functionprotein binding
P0005524molecular_functionATP binding
P0005634cellular_componentnucleus
P0006284biological_processbase-excision repair
P0006302biological_processdouble-strand break repair
P0006325biological_processchromatin organization
P0006337biological_processnucleosome disassembly
P0006338biological_processchromatin remodeling
P0006355biological_processregulation of DNA-templated transcription
P0006368biological_processtranscription elongation by RNA polymerase II
P0007010biological_processcytoskeleton organization
P0007059biological_processchromosome segregation
P0008094molecular_functionATP-dependent activity, acting on DNA
P0015616molecular_functionDNA translocase activity
P0016586cellular_componentRSC-type complex
P0016787molecular_functionhydrolase activity
P0016887molecular_functionATP hydrolysis activity
P0031055biological_processchromatin remodeling at centromere
P0042393molecular_functionhistone binding
P0045944biological_processpositive regulation of transcription by RNA polymerase II
P0051321biological_processmeiotic cell cycle
P0070577molecular_functionlysine-acetylated histone binding
P0140566molecular_functionhistone reader activity
P0140658molecular_functionATP-dependent chromatin remodeler activity
Q0000775cellular_componentchromosome, centromeric region
Q0000785cellular_componentchromatin
Q0003677molecular_functionDNA binding
Q0004386molecular_functionhelicase activity
Q0005515molecular_functionprotein binding
Q0005524molecular_functionATP binding
Q0005634cellular_componentnucleus
Q0006284biological_processbase-excision repair
Q0006302biological_processdouble-strand break repair
Q0006325biological_processchromatin organization
Q0006337biological_processnucleosome disassembly
Q0006338biological_processchromatin remodeling
Q0006355biological_processregulation of DNA-templated transcription
Q0006368biological_processtranscription elongation by RNA polymerase II
Q0007010biological_processcytoskeleton organization
Q0007059biological_processchromosome segregation
Q0008094molecular_functionATP-dependent activity, acting on DNA
Q0015616molecular_functionDNA translocase activity
Q0016586cellular_componentRSC-type complex
Q0016787molecular_functionhydrolase activity
Q0016887molecular_functionATP hydrolysis activity
Q0031055biological_processchromatin remodeling at centromere
Q0042393molecular_functionhistone binding
Q0045944biological_processpositive regulation of transcription by RNA polymerase II
Q0051321biological_processmeiotic cell cycle
Q0070577molecular_functionlysine-acetylated histone binding
Q0140566molecular_functionhistone reader activity
Q0140658molecular_functionATP-dependent chromatin remodeler activity
R0000786cellular_componentnucleosome
R0003677molecular_functionDNA binding
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005654cellular_componentnucleoplasm
R0005694cellular_componentchromosome
R0030527molecular_functionstructural constituent of chromatin
R0046982molecular_functionprotein heterodimerization activity
S0000786cellular_componentnucleosome
S0003677molecular_functionDNA binding
S0005515molecular_functionprotein binding
S0005634cellular_componentnucleus
S0005694cellular_componentchromosome
S0006334biological_processnucleosome assembly
S0030527molecular_functionstructural constituent of chromatin
S0046982molecular_functionprotein heterodimerization activity
T0000786cellular_componentnucleosome
T0003677molecular_functionDNA binding
T0005634cellular_componentnucleus
T0005694cellular_componentchromosome
T0030527molecular_functionstructural constituent of chromatin
T0046982molecular_functionprotein heterodimerization activity
U0000786cellular_componentnucleosome
U0003677molecular_functionDNA binding
U0030527molecular_functionstructural constituent of chromatin
U0046982molecular_functionprotein heterodimerization activity
V0000786cellular_componentnucleosome
V0003677molecular_functionDNA binding
V0005515molecular_functionprotein binding
V0005634cellular_componentnucleus
V0005654cellular_componentnucleoplasm
V0005694cellular_componentchromosome
V0030527molecular_functionstructural constituent of chromatin
V0046982molecular_functionprotein heterodimerization activity
W0000786cellular_componentnucleosome
W0003677molecular_functionDNA binding
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005694cellular_componentchromosome
W0006334biological_processnucleosome assembly
W0030527molecular_functionstructural constituent of chromatin
W0046982molecular_functionprotein heterodimerization activity
X0000785cellular_componentchromatin
X0003682molecular_functionchromatin binding
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0006325biological_processchromatin organization
X0006337biological_processnucleosome disassembly
X0006338biological_processchromatin remodeling
X0006366biological_processtranscription by RNA polymerase II
X0006368biological_processtranscription elongation by RNA polymerase II
X0016586cellular_componentRSC-type complex
X0070577molecular_functionlysine-acetylated histone binding
X0140566molecular_functionhistone reader activity
Y0000786cellular_componentnucleosome
Y0003677molecular_functionDNA binding
Y0030527molecular_functionstructural constituent of chromatin
Y0046982molecular_functionprotein heterodimerization activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue ZN H 1001
ChainResidue
HCYS260
HCYS263
HASN265
HCYS283
HCYS286

Functional Information from PROSITE/UniProt
site_idPS00046
Number of Residues7
DetailsHISTONE_H2A Histone H2A signature. AGLqFPV
ChainResidueDetails
TALA21-VAL27

site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
WGLY14-HIS18

site_idPS00322
Number of Residues7
DetailsHISTONE_H3_1 Histone H3 signature 1. KAPRKQL
ChainResidueDetails
RLYS14-LEU20

site_idPS00357
Number of Residues23
DetailsHISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG
ChainResidueDetails
UARG92-GLY114

site_idPS00463
Number of Residues30
DetailsZN2_CY6_FUNGAL_1 Zn(2)-C6 fungal-type DNA-binding domain signature. ACtqCRkrKigCdrakpi......CgnCvkynkpd.C
ChainResidueDetails
CALA14-CYS43
KALA13-CYS42

site_idPS00633
Number of Residues57
DetailsBROMODOMAIN_1 Bromodomain signature. FkdFiklpSrkfhp..QYYykIqqpMsineIksrdye....YedgpsnflldvelLtkNCqaY
ChainResidueDetails
XPHE77-TYR133
XSER210-PHE267
PTHR1275-TYR1332
LSER40-TYR95

site_idPS00959
Number of Residues9
DetailsHISTONE_H3_2 Histone H3 signature 2. PFqRLVREI
ChainResidueDetails
RPRO66-ILE74

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250
ChainResidueDetails
TSER1
OSER1
VARG2
VARG17

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250
ChainResidueDetails
TLYS5
OLYS5
QSER38
HCYS286
DCYS260
DCYS263
DCYS283
DCYS286

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P0C0S8
ChainResidueDetails
TLYS9
TLYS95
OLYS9
OLYS95

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-(2-hydroxyisobutyryl)lysine; alternate => ECO:0000250|UniProtKB:P0C0S8
ChainResidueDetails
TLYS36
OLYS36

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000250|UniProtKB:P0C0S8
ChainResidueDetails
TLYS74
TLYS75
OLYS74
OLYS75
SLYS8
SLYS16
SLYS44
SLYS79

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N5-methylglutamine => ECO:0000250
ChainResidueDetails
TGLN104
OGLN104
SLYS12
SLYS20

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P0C0S8
ChainResidueDetails
TLYS118
OLYS118
SLYS31
SLYS91

site_idSWS_FT_FI8
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250
ChainResidueDetails
TLYS13
VSER10
TLYS15
TLYS119
OLYS13
OLYS15
OLYS119

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: N6-lactoyllysine; alternate => ECO:0000250|UniProtKB:P84228
ChainResidueDetails
RLYS14
VLYS14
STYR51
STYR88

site_idSWS_FT_FI10
Number of Residues10
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
RLYS18
VLYS64
RLYS23
RLYS27
RLYS36
RLYS64
VLYS18
VLYS23
VLYS27
VLYS36

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Citrulline => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
RARG26
VARG26

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
RSER28
VSER28

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P68431
ChainResidueDetails
RLYS37
VLYS37
SLYS91

site_idSWS_FT_FI14
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
RTYR41
VTYR41

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84228
ChainResidueDetails
RLYS56
RLYS79
VLYS56
VLYS79

site_idSWS_FT_FI16
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
RSER57
VSER57

site_idSWS_FT_FI17
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
RTHR80
RTHR107
VTHR80
VTHR107

site_idSWS_FT_FI18
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243
ChainResidueDetails
RSER86
VSER86

site_idSWS_FT_FI19
Number of Residues2
DetailsMOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
RLYS115
VLYS115

site_idSWS_FT_FI20
Number of Residues2
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
RLYS122
VLYS122

site_idSWS_FT_FI21
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q71DI3
ChainResidueDetails
RCYS110
VCYS110

225158

PDB entries from 2024-09-18

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