6KVS
Staphylococcus aureus FabH with covalent inhibitor Oxa1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0033818 | molecular_function | beta-ketoacyl-acyl-carrier-protein synthase III activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue OAX A 701 |
| Chain | Residue |
| A | ALA424 |
| A | SER583 |
| A | GLY612 |
| A | GLY613 |
| B | PHE400 |
| A | CYS425 |
| A | PHE470 |
| A | LEU503 |
| A | MET514 |
| A | VAL519 |
| A | ALA553 |
| A | ILE557 |
| A | ASN581 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for Di-peptide OAX E 701 and CYS E 425 |
| Chain | Residue |
| A | PHE400 |
| B | ALA423 |
| B | ALA424 |
| B | SER426 |
| B | GLY427 |
| B | LEU455 |
| B | PHE470 |
| B | LEU503 |
| B | MET514 |
| B | HIS551 |
| B | ALA553 |
| B | ILE557 |
| B | ASN581 |
| B | SER583 |
| B | PHE611 |
| B | GLY612 |
| B | GLY613 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Region: {"description":"ACP-binding","evidences":[{"source":"HAMAP-Rule","id":"MF_01815","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01815","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
