6KUC

Crystal structure of Plasmodium falciparum histo-aspartic protease (HAP) zymogen (Form 2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue PEG A 401

Chain	Residue
A	ASP69
A	THR71
A	LYS101
A	SER132
A	ILE133
A	GLY134
A	ASN279

---

site_id	AC2
Number of Residues	8
Details	binding site for residue PEG A 402

Chain	Residue
A	PHE3
A	ASP4
A	VAL6
A	THR224
A	PRO291
A	ASP293
A	SER1
A	GLU2

---

site_id	AC3
Number of Residues	6
Details	binding site for residue PEG A 403

Chain	Residue
A	THR256
A	LYS264
A	VAL265
A	THR267
A	GLU269
A	LYS308

---

site_id	AC4
Number of Residues	3
Details	binding site for residue PEG A 404

Chain	Residue
A	LYS9
A	ARG91
A	HOH520

---

site_id	AC5
Number of Residues	2
Details	binding site for residue GOL A 405

Chain	Residue
A	GLU174
A	ARG176

---

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL A 406

Chain	Residue
A	GLU175
A	GLY180
A	LEU182
A	THR252
A	LYS253

---

site_id	AC7
Number of Residues	3
Details	binding site for residue GOL A 407

Chain	Residue
A	ASN30
A	ASP119
A	LYS296

---

site_id	AC8
Number of Residues	1
Details	binding site for residue GOL A 408

Chain	Residue
A	ASP10

---

site_id	AC9
Number of Residues	2
Details	binding site for residue GOL A 409

Chain	Residue
A	ARG176
A	HOH507

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	307
Details	Domain: {"description":"Peptidase A1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01103","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---