6KSW
Cryo-EM structure of the human concentrative nucleoside transporter CNT3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005337 | molecular_function | nucleoside transmembrane transporter activity |
| A | 0005345 | molecular_function | purine nucleobase transmembrane transporter activity |
| A | 0005415 | molecular_function | nucleoside:sodium symporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0006855 | biological_process | xenobiotic transmembrane transport |
| A | 0015213 | molecular_function | uridine transmembrane transporter activity |
| A | 0015293 | molecular_function | symporter activity |
| A | 0015389 | molecular_function | pyrimidine- and adenosine-specific:sodium symporter activity |
| A | 0015390 | molecular_function | purine-specific nucleoside:sodium symporter activity |
| A | 0015855 | biological_process | pyrimidine nucleobase transport |
| A | 0015860 | biological_process | purine nucleoside transmembrane transport |
| A | 0015862 | biological_process | uridine transmembrane transport |
| A | 0015864 | biological_process | pyrimidine nucleoside transport |
| A | 0016020 | cellular_component | membrane |
| A | 0031526 | cellular_component | brush border membrane |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0072531 | biological_process | pyrimidine-containing compound transmembrane transport |
| A | 1901642 | biological_process | nucleoside transmembrane transport |
| A | 1904823 | biological_process | purine nucleobase transmembrane transport |
| B | 0005337 | molecular_function | nucleoside transmembrane transporter activity |
| B | 0005345 | molecular_function | purine nucleobase transmembrane transporter activity |
| B | 0005415 | molecular_function | nucleoside:sodium symporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006805 | biological_process | xenobiotic metabolic process |
| B | 0006855 | biological_process | xenobiotic transmembrane transport |
| B | 0015213 | molecular_function | uridine transmembrane transporter activity |
| B | 0015293 | molecular_function | symporter activity |
| B | 0015389 | molecular_function | pyrimidine- and adenosine-specific:sodium symporter activity |
| B | 0015390 | molecular_function | purine-specific nucleoside:sodium symporter activity |
| B | 0015855 | biological_process | pyrimidine nucleobase transport |
| B | 0015860 | biological_process | purine nucleoside transmembrane transport |
| B | 0015862 | biological_process | uridine transmembrane transport |
| B | 0015864 | biological_process | pyrimidine nucleoside transport |
| B | 0016020 | cellular_component | membrane |
| B | 0031526 | cellular_component | brush border membrane |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0072531 | biological_process | pyrimidine-containing compound transmembrane transport |
| B | 1901642 | biological_process | nucleoside transmembrane transport |
| B | 1904823 | biological_process | purine nucleobase transmembrane transport |
| C | 0005337 | molecular_function | nucleoside transmembrane transporter activity |
| C | 0005345 | molecular_function | purine nucleobase transmembrane transporter activity |
| C | 0005415 | molecular_function | nucleoside:sodium symporter activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005789 | cellular_component | endoplasmic reticulum membrane |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006805 | biological_process | xenobiotic metabolic process |
| C | 0006855 | biological_process | xenobiotic transmembrane transport |
| C | 0015213 | molecular_function | uridine transmembrane transporter activity |
| C | 0015293 | molecular_function | symporter activity |
| C | 0015389 | molecular_function | pyrimidine- and adenosine-specific:sodium symporter activity |
| C | 0015390 | molecular_function | purine-specific nucleoside:sodium symporter activity |
| C | 0015855 | biological_process | pyrimidine nucleobase transport |
| C | 0015860 | biological_process | purine nucleoside transmembrane transport |
| C | 0015862 | biological_process | uridine transmembrane transport |
| C | 0015864 | biological_process | pyrimidine nucleoside transport |
| C | 0016020 | cellular_component | membrane |
| C | 0031526 | cellular_component | brush border membrane |
| C | 0035725 | biological_process | sodium ion transmembrane transport |
| C | 0072531 | biological_process | pyrimidine-containing compound transmembrane transport |
| C | 1901642 | biological_process | nucleoside transmembrane transport |
| C | 1904823 | biological_process | purine nucleobase transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 60 |
| Details | Transmembrane: {"description":"Helical; Name=TM1","evidences":[{"source":"PubMed","id":"32776918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 354 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"32776918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 231 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 60 |
| Details | Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"32776918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 63 |
| Details | Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"32776918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 57 |
| Details | Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"32776918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 60 |
| Details | Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"32776918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 54 |
| Details | Intramembrane: {"description":"Helical; Name=HP1","evidences":[{"source":"PubMed","id":"32776918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 66 |
| Details | Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"32776918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 63 |
| Details | Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"32776918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 75 |
| Details | Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"32776918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 57 |
| Details | Intramembrane: {"description":"Helical; Name=HP2","evidences":[{"source":"PubMed","id":"32776918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 30 |
| Details | Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"32776918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 66 |
| Details | Transmembrane: {"description":"Helical; Name=TM11","evidences":[{"source":"PubMed","id":"32776918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KSW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
