6KSW

Cryo-EM structure of the human concentrative nucleoside transporter CNT3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005337	molecular_function	nucleoside transmembrane transporter activity
A	0005345	molecular_function	purine nucleobase transmembrane transporter activity
A	0005415	molecular_function	nucleoside:sodium symporter activity
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0006855	biological_process	xenobiotic transmembrane transport
A	0015213	molecular_function	uridine transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015389	molecular_function	pyrimidine- and adenosine-specific:sodium symporter activity
A	0015390	molecular_function	purine-specific nucleoside:sodium symporter activity
A	0015855	biological_process	pyrimidine nucleobase transport
A	0015860	biological_process	purine nucleoside transmembrane transport
A	0015862	biological_process	uridine transmembrane transport
A	0015864	biological_process	pyrimidine nucleoside transport
A	0016020	cellular_component	membrane
A	0031526	cellular_component	brush border membrane
A	0035725	biological_process	sodium ion transmembrane transport
A	0072531	biological_process	pyrimidine-containing compound transmembrane transport
A	1901642	biological_process	nucleoside transmembrane transport
A	1904823	biological_process	purine nucleobase transmembrane transport
B	0005337	molecular_function	nucleoside transmembrane transporter activity
B	0005345	molecular_function	purine nucleobase transmembrane transporter activity
B	0005415	molecular_function	nucleoside:sodium symporter activity
B	0005515	molecular_function	protein binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0006805	biological_process	xenobiotic metabolic process
B	0006855	biological_process	xenobiotic transmembrane transport
B	0015213	molecular_function	uridine transmembrane transporter activity
B	0015293	molecular_function	symporter activity
B	0015389	molecular_function	pyrimidine- and adenosine-specific:sodium symporter activity
B	0015390	molecular_function	purine-specific nucleoside:sodium symporter activity
B	0015855	biological_process	pyrimidine nucleobase transport
B	0015860	biological_process	purine nucleoside transmembrane transport
B	0015862	biological_process	uridine transmembrane transport
B	0015864	biological_process	pyrimidine nucleoside transport
B	0016020	cellular_component	membrane
B	0031526	cellular_component	brush border membrane
B	0035725	biological_process	sodium ion transmembrane transport
B	0072531	biological_process	pyrimidine-containing compound transmembrane transport
B	1901642	biological_process	nucleoside transmembrane transport
B	1904823	biological_process	purine nucleobase transmembrane transport
C	0005337	molecular_function	nucleoside transmembrane transporter activity
C	0005345	molecular_function	purine nucleobase transmembrane transporter activity
C	0005415	molecular_function	nucleoside:sodium symporter activity
C	0005515	molecular_function	protein binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0006805	biological_process	xenobiotic metabolic process
C	0006855	biological_process	xenobiotic transmembrane transport
C	0015213	molecular_function	uridine transmembrane transporter activity
C	0015293	molecular_function	symporter activity
C	0015389	molecular_function	pyrimidine- and adenosine-specific:sodium symporter activity
C	0015390	molecular_function	purine-specific nucleoside:sodium symporter activity
C	0015855	biological_process	pyrimidine nucleobase transport
C	0015860	biological_process	purine nucleoside transmembrane transport
C	0015862	biological_process	uridine transmembrane transport
C	0015864	biological_process	pyrimidine nucleoside transport
C	0016020	cellular_component	membrane
C	0031526	cellular_component	brush border membrane
C	0035725	biological_process	sodium ion transmembrane transport
C	0072531	biological_process	pyrimidine-containing compound transmembrane transport
C	1901642	biological_process	nucleoside transmembrane transport
C	1904823	biological_process	purine nucleobase transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	TRANSMEM: Helical; Name=TM1 => ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW

Chain	Residue	Details
C	HIS104-LEU124
A	HIS104-LEU124
B	HIS104-LEU124

---

site_id	SWS_FT_FI2
Number of Residues	585
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
C	ASN125-ALA129
A	PRO249-PHE285
A	PRO386-SER387
A	TRP471-VAL508
A	LYS529-ILE567
A	SER615-PHE692
B	ASN125-ALA129
B	LYS196-GLY198
B	PRO249-PHE285
B	PRO386-SER387
B	TRP471-VAL508
C	LYS196-GLY198
B	LYS529-ILE567
B	SER615-PHE692
C	PRO249-PHE285
C	PRO386-SER387
C	TRP471-VAL508
C	LYS529-ILE567
C	SER615-PHE692
A	ASN125-ALA129
A	LYS196-GLY198

---

site_id	SWS_FT_FI3
Number of Residues	60
Details	TRANSMEM: Helical; Name=TM2 => ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW

Chain	Residue	Details
C	LEU130-ALA150
A	LEU130-ALA150
B	LEU130-ALA150

---

site_id	SWS_FT_FI4
Number of Residues	333
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
C	LYS151-LEU174
A	ARG350-HIS362
A	PRO410-SER444
A	SER579-GLY591
B	LYS151-LEU174
B	TYR221-ARG228
B	GLY307-GLU330
B	ARG350-HIS362
B	PRO410-SER444
B	SER579-GLY591
C	TYR221-ARG228
C	GLY307-GLU330
C	ARG350-HIS362
C	PRO410-SER444
C	SER579-GLY591
A	LYS151-LEU174
A	TYR221-ARG228
A	GLY307-GLU330

---

site_id	SWS_FT_FI5
Number of Residues	60
Details	TRANSMEM: Helical; Name=TM3 => ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW

Chain	Residue	Details
C	LYS175-ALA195
A	LYS175-ALA195
B	LYS175-ALA195

---

site_id	SWS_FT_FI6
Number of Residues	63
Details	TRANSMEM: Helical; Name=TM4 => ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW

Chain	Residue	Details
C	GLN199-LYS220
A	GLN199-LYS220
B	GLN199-LYS220

---

site_id	SWS_FT_FI7
Number of Residues	57
Details	TRANSMEM: Helical; Name=TM5 => ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW

Chain	Residue	Details
C	PRO229-ASP248
A	PRO229-ASP248
B	PRO229-ASP248

---

site_id	SWS_FT_FI8
Number of Residues	60
Details	TRANSMEM: Helical; Name=TM6 => ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW

Chain	Residue	Details
C	ALA286-LEU306
A	ALA286-LEU306
B	ALA286-LEU306

---

site_id	SWS_FT_FI9
Number of Residues	54
Details	INTRAMEM: Helical; Name=HP1 => ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW

Chain	Residue	Details
C	SER331-VAL349
A	SER331-VAL349
B	SER331-VAL349

---

site_id	SWS_FT_FI10
Number of Residues	66
Details	TRANSMEM: Helical; Name=TM7 => ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW

Chain	Residue	Details
C	ALA363-VAL385
A	ALA363-VAL385
B	ALA363-VAL385

---

site_id	SWS_FT_FI11
Number of Residues	63
Details	TRANSMEM: Helical; Name=TM8 => ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW

Chain	Residue	Details
C	SER388-TRP409
A	SER388-TRP409
B	SER388-TRP409

---

site_id	SWS_FT_FI12
Number of Residues	75
Details	TRANSMEM: Helical; Name=TM9 => ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW

Chain	Residue	Details
C	ILE445-SER470
A	ILE445-SER470
B	ILE445-SER470

---

site_id	SWS_FT_FI13
Number of Residues	57
Details	INTRAMEM: Helical; Name=HP2 => ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW

Chain	Residue	Details
C	ALA509-SER528
A	ALA509-SER528
B	ALA509-SER528

---

site_id	SWS_FT_FI14
Number of Residues	30
Details	TRANSMEM: Helical; Name=TM10 => ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW

Chain	Residue	Details
C	GLY568-THR578
A	GLY568-THR578
B	GLY568-THR578

---

site_id	SWS_FT_FI15
Number of Residues	66
Details	TRANSMEM: Helical; Name=TM11 => ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW

Chain	Residue	Details
C	ALA592-SER614
A	ALA592-SER614
B	ALA592-SER614

---