6KSE
Crystal Structure of E447A Acyl-CoA Dehydrogenase FadE5 mutant from Mycobacteria tuberculosisin complex with C18CoA
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004466 | molecular_function | long-chain fatty acyl-CoA dehydrogenase activity |
A | 0005576 | cellular_component | extracellular region |
A | 0005886 | cellular_component | plasma membrane |
A | 0006631 | biological_process | fatty acid metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
A | 0016937 | molecular_function | short-chain fatty acyl-CoA dehydrogenase activity |
A | 0052572 | biological_process | response to host immune response |
A | 0070991 | molecular_function | medium-chain fatty acyl-CoA dehydrogenase activity |
B | 0004466 | molecular_function | long-chain fatty acyl-CoA dehydrogenase activity |
B | 0005576 | cellular_component | extracellular region |
B | 0005886 | cellular_component | plasma membrane |
B | 0006631 | biological_process | fatty acid metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
B | 0016937 | molecular_function | short-chain fatty acyl-CoA dehydrogenase activity |
B | 0052572 | biological_process | response to host immune response |
B | 0070991 | molecular_function | medium-chain fatty acyl-CoA dehydrogenase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 28 |
Details | binding site for residue FAD A 701 |
Chain | Residue |
A | MET162 |
A | THR449 |
A | ALA451 |
A | ST9702 |
A | HOH873 |
A | HOH875 |
A | HOH879 |
A | HOH965 |
A | HOH1006 |
A | HOH1018 |
B | ARG326 |
A | LEU164 |
B | GLN328 |
B | ILE345 |
B | HIS348 |
B | VAL351 |
B | GLN420 |
B | THR421 |
B | GLY423 |
B | GLY424 |
B | HOH816 |
A | THR165 |
A | GLY170 |
A | SER171 |
A | PHE196 |
A | THR198 |
A | ILE442 |
A | ALA447 |
site_id | AC2 |
Number of Residues | 41 |
Details | binding site for residue ST9 A 702 |
Chain | Residue |
A | ASP93 |
A | VAL95 |
A | HIS115 |
A | TRP126 |
A | GLY130 |
A | GLY133 |
A | PHE134 |
A | MET162 |
A | SER171 |
A | VAL173 |
A | THR224 |
A | LYS225 |
A | ILE290 |
A | PHE294 |
A | GLU298 |
A | ALA300 |
A | ARG301 |
A | MET303 |
A | TYR446 |
A | ALA447 |
A | GLY448 |
A | ILE452 |
A | ASP456 |
A | ARG460 |
A | LYS461 |
A | ARG464 |
A | FAD701 |
A | HOH833 |
A | HOH863 |
A | HOH870 |
A | HOH896 |
A | HOH966 |
A | HOH983 |
A | HOH1008 |
A | HOH1014 |
A | HOH1028 |
A | HOH1036 |
A | HOH1042 |
A | HOH1047 |
A | HOH1151 |
B | LYS338 |
site_id | AC3 |
Number of Residues | 26 |
Details | binding site for residue FAD B 701 |
Chain | Residue |
A | ARG326 |
A | GLN328 |
A | ILE345 |
A | HIS348 |
A | GLN420 |
A | THR421 |
A | GLY423 |
A | GLY424 |
A | HOH832 |
A | HOH860 |
A | HOH861 |
B | MET162 |
B | LEU164 |
B | THR165 |
B | GLY170 |
B | SER171 |
B | PHE196 |
B | THR198 |
B | THR266 |
B | ILE442 |
B | THR449 |
B | ALA451 |
B | ST9702 |
B | HOH902 |
B | HOH957 |
B | HOH1056 |
site_id | AC4 |
Number of Residues | 36 |
Details | binding site for residue ST9 B 702 |
Chain | Residue |
B | GLY133 |
B | PHE134 |
B | GLN136 |
B | MET162 |
B | SER171 |
B | VAL173 |
B | THR224 |
B | LYS225 |
B | ILE290 |
B | PHE294 |
B | GLU298 |
B | GLN299 |
B | ARG301 |
B | TYR446 |
B | ALA447 |
B | GLY448 |
B | ILE452 |
B | ASP456 |
B | ARG460 |
B | LYS461 |
B | ARG464 |
B | FAD701 |
B | HOH841 |
B | HOH843 |
B | HOH866 |
B | HOH871 |
B | HOH926 |
B | HOH932 |
B | HOH948 |
B | HOH996 |
B | HOH1058 |
B | HOH1087 |
A | LYS338 |
B | GLY96 |
B | ILE97 |
B | LYS108 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:32601219 |
Chain | Residue | Details |
A | ALA447 | |
B | ALA447 |
site_id | SWS_FT_FI2 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000269|PubMed:32601219 |
Chain | Residue | Details |
A | MET162 | |
A | THR449 | |
A | ASP456 | |
A | ARG460 | |
B | MET162 | |
B | SER171 | |
B | THR198 | |
B | THR224 | |
B | ARG301 | |
B | ARG326 | |
B | LYS338 | |
A | SER171 | |
B | GLN420 | |
B | ALA447 | |
B | THR449 | |
B | ASP456 | |
B | ARG460 | |
A | THR198 | |
A | THR224 | |
A | ARG301 | |
A | ARG326 | |
A | LYS338 | |
A | GLN420 | |
A | ALA447 |