Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6KS6

TRiC at 0.2 mM ADP-AlFx, Conformation 1, 0.2-C1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005832	cellular_component	chaperonin-containing T-complex
A	0005886	cellular_component	plasma membrane
A	0006457	biological_process	protein folding
A	0016887	molecular_function	ATP hydrolysis activity
A	0051082	molecular_function	unfolded protein binding
A	0140662	molecular_function	ATP-dependent protein folding chaperone
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005832	cellular_component	chaperonin-containing T-complex
B	0006457	biological_process	protein folding
B	0016887	molecular_function	ATP hydrolysis activity
B	0051082	molecular_function	unfolded protein binding
B	0140662	molecular_function	ATP-dependent protein folding chaperone
D	0000166	molecular_function	nucleotide binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005832	cellular_component	chaperonin-containing T-complex
D	0006457	biological_process	protein folding
D	0016887	molecular_function	ATP hydrolysis activity
D	0051082	molecular_function	unfolded protein binding
D	0140662	molecular_function	ATP-dependent protein folding chaperone
E	0000166	molecular_function	nucleotide binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005832	cellular_component	chaperonin-containing T-complex
E	0006457	biological_process	protein folding
E	0016887	molecular_function	ATP hydrolysis activity
E	0051082	molecular_function	unfolded protein binding
E	0140662	molecular_function	ATP-dependent protein folding chaperone
G	0005524	molecular_function	ATP binding
G	0006457	biological_process	protein folding
G	0016887	molecular_function	ATP hydrolysis activity
G	0051082	molecular_function	unfolded protein binding
G	0140662	molecular_function	ATP-dependent protein folding chaperone
H	0000166	molecular_function	nucleotide binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005832	cellular_component	chaperonin-containing T-complex
H	0006457	biological_process	protein folding
H	0016887	molecular_function	ATP hydrolysis activity
H	0051082	molecular_function	unfolded protein binding
H	0140662	molecular_function	ATP-dependent protein folding chaperone
Q	0000166	molecular_function	nucleotide binding
Q	0005515	molecular_function	protein binding
Q	0005524	molecular_function	ATP binding
Q	0005737	cellular_component	cytoplasm
Q	0005832	cellular_component	chaperonin-containing T-complex
Q	0006457	biological_process	protein folding
Q	0016887	molecular_function	ATP hydrolysis activity
Q	0051082	molecular_function	unfolded protein binding
Q	0140662	molecular_function	ATP-dependent protein folding chaperone
Z	0000166	molecular_function	nucleotide binding
Z	0005515	molecular_function	protein binding
Z	0005524	molecular_function	ATP binding
Z	0005737	cellular_component	cytoplasm
Z	0005832	cellular_component	chaperonin-containing T-complex
Z	0006457	biological_process	protein folding
Z	0016887	molecular_function	ATP hydrolysis activity
Z	0051082	molecular_function	unfolded protein binding
Z	0140662	molecular_function	ATP-dependent protein folding chaperone
a	0000166	molecular_function	nucleotide binding
a	0005515	molecular_function	protein binding
a	0005524	molecular_function	ATP binding
a	0005737	cellular_component	cytoplasm
a	0005832	cellular_component	chaperonin-containing T-complex
a	0005886	cellular_component	plasma membrane
a	0006457	biological_process	protein folding
a	0016887	molecular_function	ATP hydrolysis activity
a	0051082	molecular_function	unfolded protein binding
a	0140662	molecular_function	ATP-dependent protein folding chaperone
b	0000166	molecular_function	nucleotide binding
b	0005515	molecular_function	protein binding
b	0005524	molecular_function	ATP binding
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005832	cellular_component	chaperonin-containing T-complex
b	0006457	biological_process	protein folding
b	0016887	molecular_function	ATP hydrolysis activity
b	0051082	molecular_function	unfolded protein binding
b	0140662	molecular_function	ATP-dependent protein folding chaperone
d	0000166	molecular_function	nucleotide binding
d	0005515	molecular_function	protein binding
d	0005524	molecular_function	ATP binding
d	0005737	cellular_component	cytoplasm
d	0005832	cellular_component	chaperonin-containing T-complex
d	0006457	biological_process	protein folding
d	0016887	molecular_function	ATP hydrolysis activity
d	0051082	molecular_function	unfolded protein binding
d	0140662	molecular_function	ATP-dependent protein folding chaperone
e	0000166	molecular_function	nucleotide binding
e	0005515	molecular_function	protein binding
e	0005524	molecular_function	ATP binding
e	0005737	cellular_component	cytoplasm
e	0005832	cellular_component	chaperonin-containing T-complex
e	0006457	biological_process	protein folding
e	0016887	molecular_function	ATP hydrolysis activity
e	0051082	molecular_function	unfolded protein binding
e	0140662	molecular_function	ATP-dependent protein folding chaperone
g	0005524	molecular_function	ATP binding
g	0006457	biological_process	protein folding
g	0016887	molecular_function	ATP hydrolysis activity
g	0051082	molecular_function	unfolded protein binding
g	0140662	molecular_function	ATP-dependent protein folding chaperone
h	0000166	molecular_function	nucleotide binding
h	0005524	molecular_function	ATP binding
h	0005737	cellular_component	cytoplasm
h	0005832	cellular_component	chaperonin-containing T-complex
h	0006457	biological_process	protein folding
h	0016887	molecular_function	ATP hydrolysis activity
h	0051082	molecular_function	unfolded protein binding
h	0140662	molecular_function	ATP-dependent protein folding chaperone
q	0000166	molecular_function	nucleotide binding
q	0005515	molecular_function	protein binding
q	0005524	molecular_function	ATP binding
q	0005737	cellular_component	cytoplasm
q	0005832	cellular_component	chaperonin-containing T-complex
q	0006457	biological_process	protein folding
q	0016887	molecular_function	ATP hydrolysis activity
q	0051082	molecular_function	unfolded protein binding
q	0140662	molecular_function	ATP-dependent protein folding chaperone
z	0000166	molecular_function	nucleotide binding
z	0005515	molecular_function	protein binding
z	0005524	molecular_function	ATP binding
z	0005737	cellular_component	cytoplasm
z	0005832	cellular_component	chaperonin-containing T-complex
z	0006457	biological_process	protein folding
z	0016887	molecular_function	ATP hydrolysis activity
z	0051082	molecular_function	unfolded protein binding
z	0140662	molecular_function	ATP-dependent protein folding chaperone

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue ADP a 601

Chain	Residue
a	PRO46
a	LEU502
a	VAL517
a	MG602
a	AF3603
a	ASP96
a	GLY97
a	THR99
a	THR162
a	SER165
a	SER166
a	GLY421
a	GLY422

site_id	AC2
Number of Residues	3
Details	binding site for residue MG a 602

Chain	Residue
a	ASP96
a	ADP601
a	AF3603

site_id	AC3
Number of Residues	8
Details	binding site for residue AF3 a 603

Chain	Residue
a	ASP65
a	ASP96
a	THR98
a	THR99
a	LYS167
a	ASP404
a	ADP601
a	MG602

site_id	AC4
Number of Residues	15
Details	binding site for residue ADP A 601

Chain	Residue
A	LEU44
A	PRO46
A	GLY97
A	THR98
A	THR99
A	SER100
A	THR162
A	SER165
A	SER166
A	GLY421
A	GLY422
A	VAL517
A	GLU519
A	MG602
A	AF3603

site_id	AC5
Number of Residues	4
Details	binding site for residue MG A 602

Chain	Residue
A	ASP96
A	LYS167
A	ADP601
A	AF3603

site_id	AC6
Number of Residues	8
Details	binding site for residue AF3 A 603

Chain	Residue
A	ASP65
A	GLY66
A	THR98
A	THR99
A	LYS167
A	ASP404
A	ADP601
A	MG602

site_id	AC7
Number of Residues	16
Details	binding site for residue ADP b 601

Chain	Residue
b	LEU37
b	ASP90
b	GLY91
b	THR93
b	SER94
b	THR159
b	SER162
b	SER163
b	GLY404
b	GLY405
b	GLU408
b	LEU444
b	ILE487
b	GLU489
b	MG602
b	AF3603

site_id	AC8
Number of Residues	3
Details	binding site for residue MG b 602

Chain	Residue
b	ASP90
b	ADP601
b	AF3603

site_id	AC9
Number of Residues	10
Details	binding site for residue AF3 b 603

Chain	Residue
b	ASN58
b	ASP59
b	ASP90
b	GLY91
b	THR92
b	THR93
b	LYS164
b	ASP386
b	ADP601
b	MG602

site_id	AD1
Number of Residues	18
Details	binding site for residue ADP B 601

Chain	Residue
B	THR36
B	LEU37
B	GLY38
B	PRO39
B	ASP90
B	GLY91
B	THR92
B	THR93
B	SER94
B	SER162
B	SER163
B	GLY404
B	LEU444
B	LEU472
B	ILE487
B	GLU489
B	MG602
B	AF3603

site_id	AD2
Number of Residues	4
Details	binding site for residue MG B 602

Chain	Residue
B	SER163
B	ADP601
B	AF3603
B	ASP90

site_id	AD3
Number of Residues	8
Details	binding site for residue AF3 B 603

Chain	Residue
B	ASP59
B	ASP90
B	THR92
B	THR93
B	LYS164
B	ASP386
B	ADP601
B	MG602

site_id	AD4
Number of Residues	19
Details	binding site for residue ADP d 601

Chain	Residue
d	LEU39
d	GLY40
d	PRO41
d	ASP91
d	GLY92
d	THR93
d	THR94
d	SER95
d	THR156
d	SER157
d	SER159
d	GLY413
d	GLY414
d	ILE482
d	VAL484
d	ILE497
d	GLN499
d	MG602
d	AF3603

site_id	AD5
Number of Residues	3
Details	binding site for residue MG d 602

Chain	Residue
d	ASP91
d	SER157
d	ADP601

site_id	AD6
Number of Residues	6
Details	binding site for residue AF3 d 603

Chain	Residue
d	ASP60
d	THR93
d	THR94
d	LYS161
d	ASP396
d	ADP601

site_id	AD7
Number of Residues	18
Details	binding site for residue ADP D 601

Chain	Residue
D	LEU39
D	GLY40
D	PRO41
D	ASP91
D	GLY92
D	THR93
D	THR94
D	THR156
D	SER159
D	SER160
D	LYS161
D	GLY414
D	LEU454
D	ILE482
D	VAL484
D	ILE497
D	MG602
D	AF3603

site_id	AD8
Number of Residues	3
Details	binding site for residue MG D 602

Chain	Residue
D	ASP91
D	SER157
D	ADP601

site_id	AD9
Number of Residues	8
Details	binding site for residue AF3 D 603

Chain	Residue
D	ASN59
D	ASP60
D	GLY61
D	THR93
D	THR94
D	LYS161
D	ASP396
D	ADP601

site_id	AE1
Number of Residues	17
Details	binding site for residue ADP e 601

Chain	Residue
e	LEU65
e	GLY66
e	PRO67
e	ASP117
e	GLY118
e	THR119
e	THR120
e	THR186
e	SER187
e	SER190
e	GLY442
e	GLY443
e	VAL527
e	ASP529
e	LYS534
e	MG602
e	AF3603

site_id	AE2
Number of Residues	3
Details	binding site for residue MG e 602

Chain	Residue
e	ASP117
e	ADP601
e	AF3603

site_id	AE3
Number of Residues	8
Details	binding site for residue AF3 e 603

Chain	Residue
e	ASP86
e	ASP117
e	THR119
e	THR120
e	LYS191
e	ASP425
e	ADP601
e	MG602

site_id	AE4
Number of Residues	15
Details	binding site for residue ADP E 601

Chain	Residue
E	GLY66
E	ASP117
E	GLY118
E	THR119
E	THR120
E	GLY189
E	SER190
E	GLY442
E	GLY443
E	LEU515
E	VAL527
E	ASP529
E	LYS534
E	MG602
E	AF3603

site_id	AE5
Number of Residues	3
Details	binding site for residue MG E 602

Chain	Residue
E	ASP117
E	ADP601
E	AF3603

site_id	AE6
Number of Residues	7
Details	binding site for residue AF3 E 603

Chain	Residue
E	ASP86
E	THR119
E	THR120
E	LYS191
E	ASP425
E	ADP601
E	MG602

site_id	AE7
Number of Residues	15
Details	binding site for residue ADP g 601

Chain	Residue
g	LEU39
g	PRO41
g	GLY92
g	THR93
g	THR94
g	THR95
g	SER158
g	THR161
g	GLY476
g	ILE544
g	GLY546
g	ILE559
g	GLU561
g	MG602
g	AF3603

site_id	AE8
Number of Residues	3
Details	binding site for residue MG g 602

Chain	Residue
g	ASP91
g	ADP601
g	AF3603

site_id	AE9
Number of Residues	9
Details	binding site for residue AF3 g 603

Chain	Residue
g	ASP60
g	GLY61
g	GLY90
g	THR93
g	THR94
g	LYS162
g	ADP601
g	MG602
g	HOH701

site_id	AF1
Number of Residues	20
Details	binding site for residue ADP G 601

Chain	Residue
G	LEU39
G	PRO41
G	ASP91
G	GLY92
G	THR93
G	THR94
G	THR95
G	SER158
G	THR161
G	GLY475
G	GLY476
G	GLY477
G	LEU516
G	ILE544
G	GLY546
G	TYR557
G	GLU561
G	LYS566
G	MG602
G	AF3603

site_id	AF2
Number of Residues	4
Details	binding site for residue MG G 602

Chain	Residue
G	ASP91
G	SER158
G	ADP601
G	AF3603

site_id	AF3
Number of Residues	8
Details	binding site for residue AF3 G 603

Chain	Residue
G	ASP60
G	ASP91
G	THR93
G	THR94
G	LYS162
G	ASP458
G	ADP601
G	MG602

site_id	AF4
Number of Residues	11
Details	binding site for residue ADP h 601

Chain	Residue
h	LEU44
h	GLY45
h	PRO46
h	ASP96
h	GLY97
h	SER167
h	SER168
h	GLY413
h	GLU498
h	MG602
h	AF3603

site_id	AF5
Number of Residues	3
Details	binding site for residue MG h 602

Chain	Residue
h	ASP96
h	ADP601
h	AF3603

site_id	AF6
Number of Residues	8
Details	binding site for residue AF3 h 603

Chain	Residue
h	ASP65
h	GLY95
h	THR98
h	THR99
h	LYS169
h	ASP395
h	ADP601
h	MG602

site_id	AF7
Number of Residues	16
Details	binding site for residue ADP H 601

Chain	Residue
H	LEU44
H	ASP96
H	GLY97
H	THR98
H	THR99
H	SER100
H	SER167
H	SER168
H	GLY412
H	GLY413
H	LEU453
H	PHE483
H	GLU498
H	LYS503
H	MG602
H	AF3603

site_id	AF8
Number of Residues	3
Details	binding site for residue MG H 602

Chain	Residue
H	ASP96
H	ADP601
H	AF3603

site_id	AF9
Number of Residues	7
Details	binding site for residue AF3 H 603

Chain	Residue
H	ASP65
H	GLY95
H	THR98
H	THR99
H	ASP395
H	ADP601
H	MG602

site_id	AG1
Number of Residues	13
Details	binding site for residue ADP q 601

Chain	Residue
q	MET46
q	PRO48
q	ASP98
q	GLY99
q	SER168
q	SER169
q	TYR172
q	GLY422
q	ALA423
q	LEU463
q	ILE517
q	ASP519
q	MG602

site_id	AG2
Number of Residues	5
Details	binding site for residue MG q 602

Chain	Residue
q	ASP98
q	VAL166
q	SER169
q	LYS170
q	ADP601

site_id	AG3
Number of Residues	4
Details	binding site for residue MG Q 601

Chain	Residue
Q	ASP98
Q	VAL166
Q	SER169
Q	ADP602

site_id	AG4
Number of Residues	15
Details	binding site for residue ADP Q 602

Chain	Residue
Q	MET46
Q	PRO48
Q	ASP98
Q	GLY99
Q	THR100
Q	ASN101
Q	SER168
Q	SER169
Q	LYS170
Q	GLY422
Q	ALA423
Q	VAL499
Q	ILE517
Q	ASP519
Q	MG601

site_id	AG5
Number of Residues	17
Details	binding site for residue ADP z 601

Chain	Residue
z	LEU37
z	PRO39
z	ASP89
z	GLY90
z	THR91
z	THR92
z	THR93
z	THR160
z	GLY414
z	ALA415
z	GLY416
z	LEU458
z	VAL491
z	ILE506
z	ASP508
z	MG602
z	AF3603

site_id	AG6
Number of Residues	3
Details	binding site for residue MG z 602

Chain	Residue
z	ASP89
z	ADP601
z	AF3603

site_id	AG7
Number of Residues	9
Details	binding site for residue AF3 z 603

Chain	Residue
z	ASP58
z	ASP89
z	THR91
z	THR92
z	LYS161
z	ASP397
z	ADP601
z	MG602
z	HOH701

site_id	AG8
Number of Residues	14
Details	binding site for residue ADP Z 601

Chain	Residue
Z	LEU37
Z	PRO39
Z	ASP89
Z	GLY90
Z	THR92
Z	THR93
Z	THR160
Z	GLY414
Z	ALA415
Z	GLY416
Z	VAL491
Z	ILE506
Z	MG602
Z	AF3603

site_id	AG9
Number of Residues	3
Details	binding site for residue MG Z 602

Chain	Residue
Z	ASP89
Z	ADP601
Z	AF3603

site_id	AH1
Number of Residues	8
Details	binding site for residue AF3 Z 603

Chain	Residue
Z	ASP58
Z	THR91
Z	THR92
Z	LYS161
Z	ASP397
Z	ADP601
Z	MG602
Z	HOH701

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	34
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGDGTTSVTIlAgelmkeakpfleegisshLIMK

Chain	Residue	Details
h	VAL94-LYS127

site_id	PS00750
Number of Residues	13
Details	TCP1_1 Chaperonins TCP-1 signature 1. KStLGPkGmdKLL

Chain	Residue	Details
b	LYS34-LEU46
d	ARG36-ILE48
e	LYS62-LEU74
q	LEU43-ILE55
z	GLU34-LEU46
g	ARG36-LEU48
a	LYS41-LEU53

site_id	PS00751
Number of Residues	17
Details	TCP1_2 Chaperonins TCP-1 signature 2. ISNDGATILklLdVvHP

Chain	Residue	Details
h	ILE62-PRO78
b	VAL56-PRO72
d	ILE57-PRO73
q	ILE64-PRO80
z	LEU55-PRO71
g	LEU57-PRO73
a	VAL62-PRO78

site_id	PS00995
Number of Residues	9
Details	TCP1_3 Chaperonins TCP-1 signature 3. QDaeVGDGT

Chain	Residue	Details
h	GLN90-THR98
b	GLN84-THR92
d	GLN85-THR93
e	GLN111-THR119
q	GLN92-THR100
z	GLN83-THR91
g	GLN85-THR93
a	GLN90-THR98

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"12872131","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)