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6KRQ

Peroxiredoxin from Aeropyrum pernix K1 (ApPrx) 0Cys F80A mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0004601molecular_functionperoxidase activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006979biological_processresponse to oxidative stress
A0008379molecular_functionthioredoxin peroxidase activity
A0016209molecular_functionantioxidant activity
A0016491molecular_functionoxidoreductase activity
A0033554biological_processcellular response to stress
A0042744biological_processhydrogen peroxide catabolic process
A0042802molecular_functionidentical protein binding
A0045454biological_processcell redox homeostasis
A0051920molecular_functionperoxiredoxin activity
A0055114biological_processobsolete oxidation-reduction process
A0070301biological_processcellular response to hydrogen peroxide
A0098869biological_processcellular oxidant detoxification
A0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
B0004601molecular_functionperoxidase activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006979biological_processresponse to oxidative stress
B0008379molecular_functionthioredoxin peroxidase activity
B0016209molecular_functionantioxidant activity
B0016491molecular_functionoxidoreductase activity
B0033554biological_processcellular response to stress
B0042744biological_processhydrogen peroxide catabolic process
B0042802molecular_functionidentical protein binding
B0045454biological_processcell redox homeostasis
B0051920molecular_functionperoxiredoxin activity
B0055114biological_processobsolete oxidation-reduction process
B0070301biological_processcellular response to hydrogen peroxide
B0098869biological_processcellular oxidant detoxification
B0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
C0004601molecular_functionperoxidase activity
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006979biological_processresponse to oxidative stress
C0008379molecular_functionthioredoxin peroxidase activity
C0016209molecular_functionantioxidant activity
C0016491molecular_functionoxidoreductase activity
C0033554biological_processcellular response to stress
C0042744biological_processhydrogen peroxide catabolic process
C0042802molecular_functionidentical protein binding
C0045454biological_processcell redox homeostasis
C0051920molecular_functionperoxiredoxin activity
C0055114biological_processobsolete oxidation-reduction process
C0070301biological_processcellular response to hydrogen peroxide
C0098869biological_processcellular oxidant detoxification
C0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
D0004601molecular_functionperoxidase activity
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006979biological_processresponse to oxidative stress
D0008379molecular_functionthioredoxin peroxidase activity
D0016209molecular_functionantioxidant activity
D0016491molecular_functionoxidoreductase activity
D0033554biological_processcellular response to stress
D0042744biological_processhydrogen peroxide catabolic process
D0042802molecular_functionidentical protein binding
D0045454biological_processcell redox homeostasis
D0051920molecular_functionperoxiredoxin activity
D0055114biological_processobsolete oxidation-reduction process
D0070301biological_processcellular response to hydrogen peroxide
D0098869biological_processcellular oxidant detoxification
D0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
E0004601molecular_functionperoxidase activity
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006979biological_processresponse to oxidative stress
E0008379molecular_functionthioredoxin peroxidase activity
E0016209molecular_functionantioxidant activity
E0016491molecular_functionoxidoreductase activity
E0033554biological_processcellular response to stress
E0042744biological_processhydrogen peroxide catabolic process
E0042802molecular_functionidentical protein binding
E0045454biological_processcell redox homeostasis
E0051920molecular_functionperoxiredoxin activity
E0055114biological_processobsolete oxidation-reduction process
E0070301biological_processcellular response to hydrogen peroxide
E0098869biological_processcellular oxidant detoxification
E0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
F0004601molecular_functionperoxidase activity
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006979biological_processresponse to oxidative stress
F0008379molecular_functionthioredoxin peroxidase activity
F0016209molecular_functionantioxidant activity
F0016491molecular_functionoxidoreductase activity
F0033554biological_processcellular response to stress
F0042744biological_processhydrogen peroxide catabolic process
F0042802molecular_functionidentical protein binding
F0045454biological_processcell redox homeostasis
F0051920molecular_functionperoxiredoxin activity
F0055114biological_processobsolete oxidation-reduction process
F0070301biological_processcellular response to hydrogen peroxide
F0098869biological_processcellular oxidant detoxification
F0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
G0004601molecular_functionperoxidase activity
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006979biological_processresponse to oxidative stress
G0008379molecular_functionthioredoxin peroxidase activity
G0016209molecular_functionantioxidant activity
G0016491molecular_functionoxidoreductase activity
G0033554biological_processcellular response to stress
G0042744biological_processhydrogen peroxide catabolic process
G0042802molecular_functionidentical protein binding
G0045454biological_processcell redox homeostasis
G0051920molecular_functionperoxiredoxin activity
G0055114biological_processobsolete oxidation-reduction process
G0070301biological_processcellular response to hydrogen peroxide
G0098869biological_processcellular oxidant detoxification
G0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
H0004601molecular_functionperoxidase activity
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006979biological_processresponse to oxidative stress
H0008379molecular_functionthioredoxin peroxidase activity
H0016209molecular_functionantioxidant activity
H0016491molecular_functionoxidoreductase activity
H0033554biological_processcellular response to stress
H0042744biological_processhydrogen peroxide catabolic process
H0042802molecular_functionidentical protein binding
H0045454biological_processcell redox homeostasis
H0051920molecular_functionperoxiredoxin activity
H0055114biological_processobsolete oxidation-reduction process
H0070301biological_processcellular response to hydrogen peroxide
H0098869biological_processcellular oxidant detoxification
H0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
I0004601molecular_functionperoxidase activity
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006979biological_processresponse to oxidative stress
I0008379molecular_functionthioredoxin peroxidase activity
I0016209molecular_functionantioxidant activity
I0016491molecular_functionoxidoreductase activity
I0033554biological_processcellular response to stress
I0042744biological_processhydrogen peroxide catabolic process
I0042802molecular_functionidentical protein binding
I0045454biological_processcell redox homeostasis
I0051920molecular_functionperoxiredoxin activity
I0055114biological_processobsolete oxidation-reduction process
I0070301biological_processcellular response to hydrogen peroxide
I0098869biological_processcellular oxidant detoxification
I0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
J0004601molecular_functionperoxidase activity
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006979biological_processresponse to oxidative stress
J0008379molecular_functionthioredoxin peroxidase activity
J0016209molecular_functionantioxidant activity
J0016491molecular_functionoxidoreductase activity
J0033554biological_processcellular response to stress
J0042744biological_processhydrogen peroxide catabolic process
J0042802molecular_functionidentical protein binding
J0045454biological_processcell redox homeostasis
J0051920molecular_functionperoxiredoxin activity
J0055114biological_processobsolete oxidation-reduction process
J0070301biological_processcellular response to hydrogen peroxide
J0098869biological_processcellular oxidant detoxification
J0140824molecular_functionthioredoxin-dependent peroxiredoxin activity
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue CIT A 301
ChainResidue
ATHR47
APRO48
AVAL49
ASER50
AARG126
AMET145
AHOH401
BALA170
BPRO189

site_idAC2
Number of Residues10
Detailsbinding site for residue CIT B 301
ChainResidue
AALA170
APRO188
APRO189
BTHR47
BPRO48
BVAL49
BSER50
BARG126
BMET145
BHOH406

site_idAC3
Number of Residues8
Detailsbinding site for residue CIT C 301
ChainResidue
CTHR47
CPRO48
CVAL49
CSER50
CARG126
DALA170
DPRO188
DPRO189

site_idAC4
Number of Residues8
Detailsbinding site for residue CIT D 301
ChainResidue
CALA170
CPRO189
DTHR47
DPRO48
DVAL49
DSER50
DARG126
DMET145

site_idAC5
Number of Residues8
Detailsbinding site for residue CIT E 301
ChainResidue
ETHR47
EPRO48
EVAL49
ESER50
EARG126
EHOH450
FALA170
FPRO189

site_idAC6
Number of Residues9
Detailsbinding site for residue CIT F 301
ChainResidue
EALA170
EPRO188
EPRO189
FTHR47
FPRO48
FVAL49
FSER50
FARG126
FMET145

site_idAC7
Number of Residues9
Detailsbinding site for residue CIT G 301
ChainResidue
GTHR47
GPRO48
GVAL49
GSER50
GARG126
GMET145
GHOH446
HPRO188
HPRO189

site_idAC8
Number of Residues9
Detailsbinding site for residue CIT H 301
ChainResidue
GALA170
GPRO188
GPRO189
HTHR47
HPRO48
HVAL49
HSER50
HARG126
HMET145

site_idAC9
Number of Residues9
Detailsbinding site for residue CIT I 301
ChainResidue
ITHR47
IPRO48
IVAL49
ISER50
IARG126
IMET145
JALA170
JPRO188
JPRO189

site_idAD1
Number of Residues10
Detailsbinding site for residue CIT J 301
ChainResidue
IALA170
IPRO188
IPRO189
JTHR47
JPRO48
JVAL49
JSER50
JARG126
JMET145
JHOH405

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000255|HAMAP-Rule:MF_00401, ECO:0000269|PubMed:16214169, ECO:0000269|PubMed:18436649
ChainResidueDetails
ASER50
JSER50
BSER50
CSER50
DSER50
ESER50
FSER50
GSER50
HSER50
ISER50

site_idSWS_FT_FI2
Number of Residues10
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00401, ECO:0000269|PubMed:19819903
ChainResidueDetails
AARG126
JARG126
BARG126
CARG126
DARG126
EARG126
FARG126
GARG126
HARG126
IARG126

226707

PDB entries from 2024-10-30

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