6KOC
X-ray Structure of the proton-pumping cytochrome aa3-600 menaquinol oxidase from Bacillus subtilis complexed with 3-iodo-N-oxo-2-heptyl-4-hydroxyquinoline
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004129 | molecular_function | cytochrome-c oxidase activity |
A | 0005507 | molecular_function | copper ion binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0006119 | biological_process | oxidative phosphorylation |
A | 0009060 | biological_process | aerobic respiration |
A | 0015990 | biological_process | electron transport coupled proton transport |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016682 | molecular_function | oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor |
A | 0020037 | molecular_function | heme binding |
A | 0022904 | biological_process | respiratory electron transport chain |
A | 0042773 | biological_process | ATP synthesis coupled electron transport |
A | 0046872 | molecular_function | metal ion binding |
A | 0070469 | cellular_component | respirasome |
A | 1902600 | biological_process | proton transmembrane transport |
B | 0004129 | molecular_function | cytochrome-c oxidase activity |
B | 0005507 | molecular_function | copper ion binding |
B | 0005886 | cellular_component | plasma membrane |
B | 0009486 | molecular_function | cytochrome bo3 ubiquinol oxidase activity |
B | 0016020 | cellular_component | membrane |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016682 | molecular_function | oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor |
B | 0022900 | biological_process | electron transport chain |
B | 0042773 | biological_process | ATP synthesis coupled electron transport |
B | 0045121 | cellular_component | membrane raft |
B | 0055085 | biological_process | transmembrane transport |
B | 0070469 | cellular_component | respirasome |
B | 1902600 | biological_process | proton transmembrane transport |
C | 0004129 | molecular_function | cytochrome-c oxidase activity |
C | 0005886 | cellular_component | plasma membrane |
C | 0009055 | molecular_function | electron transfer activity |
C | 0009319 | cellular_component | cytochrome o ubiquinol oxidase complex |
C | 0009486 | molecular_function | cytochrome bo3 ubiquinol oxidase activity |
C | 0015990 | biological_process | electron transport coupled proton transport |
C | 0016020 | cellular_component | membrane |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016682 | molecular_function | oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor |
C | 0019646 | biological_process | aerobic electron transport chain |
C | 0022904 | biological_process | respiratory electron transport chain |
C | 0042773 | biological_process | ATP synthesis coupled electron transport |
D | 0016020 | cellular_component | membrane |
E | 0004129 | molecular_function | cytochrome-c oxidase activity |
E | 0005507 | molecular_function | copper ion binding |
E | 0005886 | cellular_component | plasma membrane |
E | 0006119 | biological_process | oxidative phosphorylation |
E | 0009060 | biological_process | aerobic respiration |
E | 0015990 | biological_process | electron transport coupled proton transport |
E | 0016020 | cellular_component | membrane |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0016682 | molecular_function | oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor |
E | 0020037 | molecular_function | heme binding |
E | 0022904 | biological_process | respiratory electron transport chain |
E | 0042773 | biological_process | ATP synthesis coupled electron transport |
E | 0046872 | molecular_function | metal ion binding |
E | 0070469 | cellular_component | respirasome |
E | 1902600 | biological_process | proton transmembrane transport |
F | 0004129 | molecular_function | cytochrome-c oxidase activity |
F | 0005507 | molecular_function | copper ion binding |
F | 0005886 | cellular_component | plasma membrane |
F | 0009486 | molecular_function | cytochrome bo3 ubiquinol oxidase activity |
F | 0016020 | cellular_component | membrane |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0016682 | molecular_function | oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor |
F | 0022900 | biological_process | electron transport chain |
F | 0042773 | biological_process | ATP synthesis coupled electron transport |
F | 0045121 | cellular_component | membrane raft |
F | 0055085 | biological_process | transmembrane transport |
F | 0070469 | cellular_component | respirasome |
F | 1902600 | biological_process | proton transmembrane transport |
G | 0004129 | molecular_function | cytochrome-c oxidase activity |
G | 0005886 | cellular_component | plasma membrane |
G | 0009055 | molecular_function | electron transfer activity |
G | 0009319 | cellular_component | cytochrome o ubiquinol oxidase complex |
G | 0009486 | molecular_function | cytochrome bo3 ubiquinol oxidase activity |
G | 0015990 | biological_process | electron transport coupled proton transport |
G | 0016020 | cellular_component | membrane |
G | 0016491 | molecular_function | oxidoreductase activity |
G | 0016682 | molecular_function | oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor |
G | 0019646 | biological_process | aerobic electron transport chain |
G | 0022904 | biological_process | respiratory electron transport chain |
G | 0042773 | biological_process | ATP synthesis coupled electron transport |
H | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 27 |
Details | binding site for residue HEA A 1001 |
Chain | Residue |
A | PHE69 |
A | HIS102 |
A | GLY103 |
A | MET106 |
A | ILE107 |
A | GLY165 |
A | TRP166 |
A | PHE416 |
A | HIS417 |
A | LEU420 |
A | ILE421 |
A | GLY72 |
A | VAL425 |
A | GLN467 |
A | ARG477 |
A | ARG478 |
A | ALA499 |
A | MET502 |
A | GLY503 |
A | PHE506 |
A | VAL73 |
A | LEU76 |
A | MET78 |
A | ARG79 |
A | TYR95 |
A | PHE99 |
A | THR100 |
site_id | AC2 |
Number of Residues | 23 |
Details | binding site for residue HEA A 1002 |
Chain | Residue |
A | TRP166 |
A | TRP276 |
A | VAL283 |
A | TYR284 |
A | ILE287 |
A | HIS329 |
A | HIS330 |
A | THR348 |
A | SER352 |
A | GLY356 |
A | GLY391 |
A | GLY394 |
A | LEU397 |
A | ALA398 |
A | ASP403 |
A | HIS407 |
A | LEU412 |
A | HIS415 |
A | PHE416 |
A | VAL419 |
A | LEU420 |
B | PHE36 |
B | ILE78 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue CU A 1003 |
Chain | Residue |
A | HIS280 |
A | HIS329 |
A | HIS330 |
site_id | AC4 |
Number of Residues | 11 |
Details | binding site for residue IHQ A 1004 |
Chain | Residue |
A | LEU17 |
A | ARG70 |
A | VAL73 |
A | ASP74 |
A | MET77 |
A | HIS94 |
A | GLU97 |
A | ILE98 |
A | THR101 |
A | PHE156 |
A | SER161 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue CU E 1003 |
Chain | Residue |
E | HIS280 |
E | HIS329 |
E | HIS330 |
site_id | AC6 |
Number of Residues | 11 |
Details | binding site for residue IHQ E 1004 |
Chain | Residue |
E | LEU17 |
E | ARG70 |
E | VAL73 |
E | ASP74 |
E | MET77 |
E | HIS94 |
E | GLU97 |
E | ILE98 |
E | THR101 |
E | PHE156 |
E | SER161 |
site_id | AC7 |
Number of Residues | 33 |
Details | binding site for Di-peptide HEA E 1001 and ARG E 79 |
Chain | Residue |
E | HIS417 |
E | LEU420 |
E | ILE421 |
E | GLN467 |
E | ARG477 |
E | ARG478 |
E | SER495 |
E | THR496 |
E | ALA499 |
E | MET502 |
E | GLY503 |
E | PHE506 |
E | PHE69 |
E | GLY72 |
E | GLY75 |
E | LEU76 |
E | MET77 |
E | MET78 |
E | ALA80 |
E | GLN81 |
E | LEU82 |
E | ALA83 |
E | TYR95 |
E | PHE99 |
E | THR100 |
E | HIS102 |
E | GLY103 |
E | MET106 |
E | ILE107 |
E | GLY165 |
E | TRP166 |
E | TYR410 |
E | PHE416 |
site_id | AC8 |
Number of Residues | 24 |
Details | binding site for Di-peptide HEA E 1002 and SER E 352 |
Chain | Residue |
E | TRP166 |
E | TRP276 |
E | VAL283 |
E | TYR284 |
E | HIS329 |
E | HIS330 |
E | THR348 |
E | MET349 |
E | ILE351 |
E | ILE353 |
E | GLY356 |
E | ILE359 |
E | GLY391 |
E | GLY394 |
E | LEU397 |
E | ALA398 |
E | ASP403 |
E | HIS407 |
E | LEU412 |
E | HIS415 |
E | PHE416 |
E | VAL419 |
E | LEU420 |
F | PHE36 |
Functional Information from PROSITE/UniProt
site_id | PS00077 |
Number of Residues | 55 |
Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WIWGHPeVyivilpafgifseiissfarkqlfgykamvgsiiaisvlsflvwt..HH |
Chain | Residue | Details |
A | TRP276-HIS330 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 240 |
Details | TRANSMEM: Helical => ECO:0000255 |
Chain | Residue | Details |
C | PHE27-VAL47 | |
G | PHE118-PHE138 | |
G | LEU140-ILE160 | |
G | PHE184-LEU204 | |
E | ASN336-PHE343 | |
E | ALA398-GLN405 | |
E | GLN473-THR490 | |
E | PHE605-MET610 | |
C | LEU66-HIS86 | |
C | GLY95-ILE115 | |
C | PHE118-PHE138 | |
C | LEU140-ILE160 | |
C | PHE184-LEU204 | |
G | PHE27-VAL47 | |
G | LEU66-HIS86 | |
G | GLY95-ILE115 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | LIPID: S-diacylglycerol cysteine => ECO:0000255|PROSITE-ProRule:PRU00303 |
Chain | Residue | Details |
B | CYS1 | |
A | LEU378-LEU397 | |
A | TYR406-VAL425 | |
A | PHE453-LEU472 | |
A | LEU491-CYS510 | |
A | ASN585-VAL604 | |
A | GLY611-ASN631 | |
E | ILE16-LEU34 | |
E | GLY57-GLY75 | |
E | ILE98-GLY117 | |
E | LEU140-VAL157 | |
F | CYS1 | |
E | GLN191-LEU209 | |
E | THR228-LEU246 | |
E | ASN273-GLY292 | |
E | ILE316-GLY335 | |
E | PHE344-TRP362 | |
E | LEU378-LEU397 | |
E | TYR406-VAL425 | |
E | PHE453-LEU472 | |
E | LEU491-CYS510 | |
E | ASN585-VAL604 | |
A | ILE98-GLY117 | |
E | GLY611-ASN631 | |
A | LEU140-VAL157 | |
A | GLN191-LEU209 | |
A | THR228-LEU246 | |
A | ASN273-GLY292 | |
A | ILE316-GLY335 | |
A | PHE344-TRP362 |
site_id | SWS_FT_FI3 |
Number of Residues | 422 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | THR35-LEU56 | |
E | LEU118-ASN139 | |
E | LYS210-THR227 | |
E | ILE293-SER315 | |
E | LEU363-MET377 | |
E | PHE426-PHE452 | |
E | TYR511-SER584 | |
E | GLY632-GLU649 | |
A | LEU118-ASN139 | |
A | LYS210-THR227 | |
A | ILE293-SER315 | |
A | LEU363-MET377 | |
A | PHE426-PHE452 | |
A | TYR511-SER584 | |
A | GLY632-GLU649 | |
E | THR35-LEU56 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | BINDING: axial binding residue => ECO:0000250 |
Chain | Residue | Details |
A | HIS102 | |
A | HIS415 | |
A | HIS417 | |
E | HIS102 | |
E | HIS415 | |
E | HIS417 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | HIS280 | |
A | TYR284 | |
A | HIS329 | |
A | HIS330 | |
E | HIS280 | |
E | TYR284 | |
E | HIS329 | |
E | HIS330 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000250 |
Chain | Residue | Details |
A | HIS280 | |
A | TYR284 | |
E | HIS280 | |
E | TYR284 |