6KOB

X-ray Structure of the proton-pumping cytochrome aa3-600 menaquinol oxidase from Bacillus subtilis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004129	molecular_function	cytochrome-c oxidase activity
A	0005507	molecular_function	copper ion binding
A	0005886	cellular_component	plasma membrane
A	0006119	biological_process	oxidative phosphorylation
A	0006811	biological_process	monoatomic ion transport
A	0009060	biological_process	aerobic respiration
A	0015990	biological_process	electron transport coupled proton transport
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016682	molecular_function	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A	0020037	molecular_function	heme binding
A	0022904	biological_process	respiratory electron transport chain
A	0042773	biological_process	ATP synthesis coupled electron transport
A	0046872	molecular_function	metal ion binding
A	1902600	biological_process	proton transmembrane transport
B	0004129	molecular_function	cytochrome-c oxidase activity
B	0005507	molecular_function	copper ion binding
B	0005886	cellular_component	plasma membrane
B	0009486	molecular_function	cytochrome bo3 ubiquinol oxidase activity
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016682	molecular_function	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B	0022900	biological_process	electron transport chain
B	0022904	biological_process	respiratory electron transport chain
B	0042773	biological_process	ATP synthesis coupled electron transport
B	0045121	cellular_component	membrane raft
B	0055085	biological_process	transmembrane transport
B	0098803	cellular_component	respiratory chain complex
B	1902600	biological_process	proton transmembrane transport
C	0004129	molecular_function	cytochrome-c oxidase activity
C	0005886	cellular_component	plasma membrane
C	0009055	molecular_function	electron transfer activity
C	0009060	biological_process	aerobic respiration
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016682	molecular_function	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C	0019646	biological_process	aerobic electron transport chain
C	0022904	biological_process	respiratory electron transport chain
C	0042773	biological_process	ATP synthesis coupled electron transport
C	1902600	biological_process	proton transmembrane transport
D	0016020	cellular_component	membrane
E	0004129	molecular_function	cytochrome-c oxidase activity
E	0005507	molecular_function	copper ion binding
E	0005886	cellular_component	plasma membrane
E	0006119	biological_process	oxidative phosphorylation
E	0006811	biological_process	monoatomic ion transport
E	0009060	biological_process	aerobic respiration
E	0015990	biological_process	electron transport coupled proton transport
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0016682	molecular_function	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E	0020037	molecular_function	heme binding
E	0022904	biological_process	respiratory electron transport chain
E	0042773	biological_process	ATP synthesis coupled electron transport
E	0046872	molecular_function	metal ion binding
E	1902600	biological_process	proton transmembrane transport
F	0004129	molecular_function	cytochrome-c oxidase activity
F	0005507	molecular_function	copper ion binding
F	0005886	cellular_component	plasma membrane
F	0009486	molecular_function	cytochrome bo3 ubiquinol oxidase activity
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0016682	molecular_function	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F	0022900	biological_process	electron transport chain
F	0022904	biological_process	respiratory electron transport chain
F	0042773	biological_process	ATP synthesis coupled electron transport
F	0045121	cellular_component	membrane raft
F	0055085	biological_process	transmembrane transport
F	0098803	cellular_component	respiratory chain complex
F	1902600	biological_process	proton transmembrane transport
G	0004129	molecular_function	cytochrome-c oxidase activity
G	0005886	cellular_component	plasma membrane
G	0009055	molecular_function	electron transfer activity
G	0009060	biological_process	aerobic respiration
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016682	molecular_function	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G	0019646	biological_process	aerobic electron transport chain
G	0022904	biological_process	respiratory electron transport chain
G	0042773	biological_process	ATP synthesis coupled electron transport
G	1902600	biological_process	proton transmembrane transport
H	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	binding site for residue HEA A 1001

Chain	Residue
A	PHE69
A	HIS102
A	GLY103
A	MET106
A	ILE107
A	GLY165
A	TRP166
A	TYR410
A	PHE416
A	HIS417
A	ILE421
A	GLY72
A	VAL425
A	GLN467
A	ARG477
A	ARG478
A	ALA499
A	MET502
A	GLY503
A	PHE506
A	VAL73
A	LEU76
A	MET78
A	ARG79
A	TYR95
A	PHE99
A	THR100

---

site_id	AC2
Number of Residues	24
Details	binding site for residue HEA A 1002

Chain	Residue
A	TRP166
A	TRP276
A	VAL283
A	TYR284
A	ILE287
A	HIS329
A	HIS330
A	THR348
A	SER352
A	GLY356
A	ILE359
A	GLY394
A	LEU397
A	ALA398
A	ASP403
A	HIS407
A	LEU412
A	HIS415
A	PHE416
A	VAL419
A	LEU420
A	ARG477
B	PHE36
B	ILE78

---

site_id	AC3
Number of Residues	3
Details	binding site for residue CU A 1003

Chain	Residue
A	HIS280
A	HIS329
A	HIS330

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MQ7 A 1004

Chain	Residue
A	ILE23
A	ILE66
A	ARG70
A	VAL73

---

site_id	AC5
Number of Residues	3
Details	binding site for residue CU E 1003

Chain	Residue
E	HIS280
E	HIS329
E	HIS330

---

site_id	AC6
Number of Residues	3
Details	binding site for residue MQ7 E 1004

Chain	Residue
E	ILE23
E	ILE66
E	VAL73

---

site_id	AC7
Number of Residues	32
Details	binding site for Di-peptide HEA E 1001 and ARG E 79

Chain	Residue
E	PHE69
E	GLY72
E	VAL73
E	GLY75
E	LEU76
E	MET77
E	MET78
E	ALA80
E	GLN81
E	LEU82
E	ALA83
E	TYR95
E	PHE99
E	THR100
E	HIS102
E	GLY103
E	MET106
E	ILE107
E	GLY165
E	TRP166
E	TYR410
E	PHE416
E	HIS417
E	GLN467
E	ARG477
E	ARG478
E	SER495
E	THR496
E	ALA499
E	MET502
E	GLY503
E	PHE506

---

site_id	AC8
Number of Residues	28
Details	binding site for Di-peptide HEA E 1002 and SER E 352

Chain	Residue
E	TYR284
E	ILE287
E	HIS329
E	HIS330
E	THR348
E	MET349
E	ALA350
E	ILE351
E	ILE353
E	GLY356
E	ILE359
E	GLY394
E	LEU397
E	ALA398
E	ASP403
E	HIS407
E	LEU412
E	HIS415
E	PHE416
E	VAL419
E	LEU420
E	ARG477
F	LEU29
F	PHE36
F	TRP71
E	TRP166
E	TRP276
E	VAL283

---

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WIWGHPeVyivilpafgifseiissfarkqlfgykamvgsiiaisvlsflvwt..HH

Chain	Residue	Details
A	TRP276-HIS330

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	838
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	242
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	228
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"description":"axial binding residue","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Cross-link: {"description":"1'-histidyl-3'-tyrosine (His-Tyr)","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---