6KO9
Crystal structure of the Gefitinib Intermediate 1 bound RamR determined with XtaLAB Synergy
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0003723 | molecular_function | RNA binding |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0003723 | molecular_function | RNA binding |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0003723 | molecular_function | RNA binding |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0003723 | molecular_function | RNA binding |
| D | 0006351 | biological_process | DNA-templated transcription |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue XZ1 A 201 |
| Chain | Residue |
| A | TYR59 |
| A | LEU156 |
| A | LEU188 |
| A | HOH322 |
| A | HOH326 |
| A | HOH330 |
| A | HOH399 |
| A | LYS63 |
| A | LEU66 |
| A | TYR92 |
| A | ILE106 |
| A | ALA110 |
| A | VAL138 |
| A | ASP152 |
| A | PHE155 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | GLN19 |
| A | HIS99 |
| A | PRO100 |
| A | ALA101 |
| A | ARG102 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue XZ1 B 201 |
| Chain | Residue |
| B | LEU66 |
| B | ILE88 |
| B | TYR92 |
| B | ILE106 |
| B | ALA110 |
| B | LEU130 |
| B | VAL138 |
| B | ARG148 |
| B | ASP152 |
| B | PHE155 |
| B | LEU156 |
| B | MET184 |
| B | HOH303 |
| B | HOH336 |
| B | HOH347 |
| B | HOH354 |
| B | HOH389 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 202 |
| Chain | Residue |
| B | GLN19 |
| B | HIS99 |
| B | PRO100 |
| B | ALA101 |
| B | ARG102 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | binding site for residue XZ1 C 201 |
| Chain | Residue |
| C | TYR59 |
| C | LYS63 |
| C | LEU66 |
| C | TYR92 |
| C | VAL138 |
| C | ASP152 |
| C | PHE155 |
| C | LEU156 |
| C | MET184 |
| C | HOH312 |
| C | HOH337 |
| C | HOH346 |
| C | HOH351 |
| C | HOH355 |
| C | HOH365 |
| C | HOH393 |
| C | HOH433 |
| C | HOH438 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 C 202 |
| Chain | Residue |
| C | GLN19 |
| C | HIS99 |
| C | PRO100 |
| C | ALA101 |
| C | ARG102 |
| C | HOH341 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | binding site for residue XZ1 D 201 |
| Chain | Residue |
| D | LEU66 |
| D | ILE88 |
| D | TYR92 |
| D | ILE106 |
| D | ALA110 |
| D | LEU130 |
| D | ASP152 |
| D | PHE155 |
| D | LEU188 |
| D | HOH303 |
| D | HOH340 |
| D | HOH357 |
| D | HOH381 |
| D | HOH405 |
| D | HOH426 |
| D | HOH434 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 202 |
| Chain | Residue |
| A | ARG35 |
| D | THR50 |
| D | LYS51 |
| D | ASP52 |
| D | HOH325 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 D 203 |
| Chain | Residue |
| D | GLN19 |
| D | HIS99 |
| D | PRO100 |
| D | ALA101 |
| D | ARG102 |
| D | HOH349 |
| D | HOH395 |
Functional Information from PROSITE/UniProt
| site_id | PS01081 |
| Number of Residues | 31 |
| Details | HTH_TETR_1 TetR-type HTH domain signature. GIaa.STavIarnagVAeGtLFrYFaTKdelI |
| Chain | Residue | Details |
| A | GLY25-ILE55 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 76 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
