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6KL7

Beta-arrestin 1 mutant S13D/T275D

Functional Information from GO Data
ChainGOidnamespacecontents
A0000785cellular_componentchromatin
A0001664molecular_functionG protein-coupled receptor binding
A0001934biological_processpositive regulation of protein phosphorylation
A0002031biological_processG protein-coupled receptor internalization
A0002092biological_processpositive regulation of receptor internalization
A0003713molecular_functiontranscription coactivator activity
A0004402molecular_functionhistone acetyltransferase activity
A0005096molecular_functionGTPase activator activity
A0005102molecular_functionsignaling receptor binding
A0005159molecular_functioninsulin-like growth factor receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005905cellular_componentclathrin-coated pit
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0006511biological_processubiquitin-dependent protein catabolic process
A0006897biological_processendocytosis
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
A0007601biological_processvisual perception
A0007602biological_processphototransduction
A0008277biological_processregulation of G protein-coupled receptor signaling pathway
A0008284biological_processpositive regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0009968biological_processnegative regulation of signal transduction
A0014069cellular_componentpostsynaptic density
A0015031biological_processprotein transport
A0016323cellular_componentbasolateral plasma membrane
A0016567biological_processprotein ubiquitination
A0019899molecular_functionenzyme binding
A0030276molecular_functionclathrin binding
A0030331molecular_functionnuclear estrogen receptor binding
A0031143cellular_componentpseudopodium
A0031397biological_processnegative regulation of protein ubiquitination
A0031398biological_processpositive regulation of protein ubiquitination
A0031410cellular_componentcytoplasmic vesicle
A0031434molecular_functionmitogen-activated protein kinase kinase binding
A0031625molecular_functionubiquitin protein ligase binding
A0031691molecular_functionalpha-1A adrenergic receptor binding
A0031692molecular_functionalpha-1B adrenergic receptor binding
A0031701molecular_functionangiotensin receptor binding
A0031762molecular_functionfollicle-stimulating hormone receptor binding
A0031896molecular_functionV2 vasopressin receptor binding
A0032715biological_processnegative regulation of interleukin-6 production
A0032717biological_processnegative regulation of interleukin-8 production
A0032960biological_processregulation of inositol trisphosphate biosynthetic process
A0034393biological_processpositive regulation of smooth muscle cell apoptotic process
A0035025biological_processpositive regulation of Rho protein signal transduction
A0035612molecular_functionAP-2 adaptor complex binding
A0035615molecular_functionclathrin adaptor activity
A0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
A0042699biological_processfollicle-stimulating hormone signaling pathway
A0042981biological_processregulation of apoptotic process
A0042995cellular_componentcell projection
A0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043149biological_processstress fiber assembly
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043197cellular_componentdendritic spine
A0043278biological_processresponse to morphine
A0043410biological_processpositive regulation of MAPK cascade
A0043524biological_processnegative regulation of neuron apoptotic process
A0044325molecular_functiontransmembrane transporter binding
A0045211cellular_componentpostsynaptic membrane
A0045309molecular_functionprotein phosphorylated amino acid binding
A0045746biological_processnegative regulation of Notch signaling pathway
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0050975biological_processsensory perception of touch
A0051219molecular_functionphosphoprotein binding
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0098978cellular_componentglutamatergic synapse
A1990763molecular_functionarrestin family protein binding
B0000785cellular_componentchromatin
B0001664molecular_functionG protein-coupled receptor binding
B0001934biological_processpositive regulation of protein phosphorylation
B0002031biological_processG protein-coupled receptor internalization
B0002092biological_processpositive regulation of receptor internalization
B0003713molecular_functiontranscription coactivator activity
B0004402molecular_functionhistone acetyltransferase activity
B0005096molecular_functionGTPase activator activity
B0005102molecular_functionsignaling receptor binding
B0005159molecular_functioninsulin-like growth factor receptor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005905cellular_componentclathrin-coated pit
B0006355biological_processregulation of DNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0006511biological_processubiquitin-dependent protein catabolic process
B0006897biological_processendocytosis
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007188biological_processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
B0007601biological_processvisual perception
B0007602biological_processphototransduction
B0008277biological_processregulation of G protein-coupled receptor signaling pathway
B0008284biological_processpositive regulation of cell population proliferation
B0009410biological_processresponse to xenobiotic stimulus
B0009968biological_processnegative regulation of signal transduction
B0014069cellular_componentpostsynaptic density
B0015031biological_processprotein transport
B0016323cellular_componentbasolateral plasma membrane
B0016567biological_processprotein ubiquitination
B0019899molecular_functionenzyme binding
B0030276molecular_functionclathrin binding
B0030331molecular_functionnuclear estrogen receptor binding
B0031143cellular_componentpseudopodium
B0031397biological_processnegative regulation of protein ubiquitination
B0031398biological_processpositive regulation of protein ubiquitination
B0031410cellular_componentcytoplasmic vesicle
B0031434molecular_functionmitogen-activated protein kinase kinase binding
B0031625molecular_functionubiquitin protein ligase binding
B0031691molecular_functionalpha-1A adrenergic receptor binding
B0031692molecular_functionalpha-1B adrenergic receptor binding
B0031701molecular_functionangiotensin receptor binding
B0031762molecular_functionfollicle-stimulating hormone receptor binding
B0031896molecular_functionV2 vasopressin receptor binding
B0032715biological_processnegative regulation of interleukin-6 production
B0032717biological_processnegative regulation of interleukin-8 production
B0032960biological_processregulation of inositol trisphosphate biosynthetic process
B0034393biological_processpositive regulation of smooth muscle cell apoptotic process
B0035025biological_processpositive regulation of Rho protein signal transduction
B0035612molecular_functionAP-2 adaptor complex binding
B0035615molecular_functionclathrin adaptor activity
B0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
B0042699biological_processfollicle-stimulating hormone signaling pathway
B0042981biological_processregulation of apoptotic process
B0042995cellular_componentcell projection
B0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043149biological_processstress fiber assembly
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043197cellular_componentdendritic spine
B0043278biological_processresponse to morphine
B0043410biological_processpositive regulation of MAPK cascade
B0043524biological_processnegative regulation of neuron apoptotic process
B0044325molecular_functiontransmembrane transporter binding
B0045211cellular_componentpostsynaptic membrane
B0045309molecular_functionprotein phosphorylated amino acid binding
B0045746biological_processnegative regulation of Notch signaling pathway
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0050975biological_processsensory perception of touch
B0051219molecular_functionphosphoprotein binding
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0098978cellular_componentglutamatergic synapse
B1990763molecular_functionarrestin family protein binding
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue BA A 1001
ChainResidue
AGLU256
ATHR273

site_idAC2
Number of Residues1
Detailsbinding site for residue BA A 1002
ChainResidue
ATHR186

site_idAC3
Number of Residues1
Detailsbinding site for residue BA A 1003
ChainResidue
AGLU110

site_idAC4
Number of Residues3
Detailsbinding site for residue EDO A 1004
ChainResidue
ASER302
ATHR304
AILE317

site_idAC5
Number of Residues1
Detailsbinding site for residue BA B 1001
ChainResidue
BTHR273

site_idAC6
Number of Residues2
Detailsbinding site for residue BA B 1002
ChainResidue
BTHR186
BGLU185

Functional Information from PROSITE/UniProt
site_idPS00295
Number of Residues19
DetailsARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL
ChainResidueDetails
APHE61-LEU79

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ALYS250
AMET255
ALYS324
ALYS326
BLYS250
BMET255
BLYS324
BLYS326

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8BWG8
ChainResidueDetails
ATYR47
BTYR47

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by GRK5 => ECO:0000250
ChainResidueDetails
ASER412
BSER412

227111

PDB entries from 2024-11-06

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