6KK4
Crystal structure of Zika NS2B-NS3 protease with compound 9
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | binding site for residue DE0 B 201 |
| Chain | Residue |
| A | GLY82 |
| B | ASP129 |
| B | TYR130 |
| B | ALA132 |
| B | SER135 |
| B | GLY151 |
| B | ASN152 |
| B | GLY153 |
| B | VAL155 |
| B | GLY159 |
| B | TYR161 |
| A | ASP83 |
| B | VAL176 |
| B | GLU177 |
| B | HOH318 |
| B | HOH323 |
| B | HOH324 |
| B | HOH325 |
| B | HOH334 |
| B | HOH342 |
| B | HOH373 |
| B | HOH376 |
| A | PHE84 |
| B | HOH382 |
| B | TRP50 |
| B | HIS51 |
| B | TYR68 |
| B | GLY70 |
| B | ASP71 |
| B | VAL72 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 202 |
| Chain | Residue |
| B | ALA88 |
| B | TRP89 |
| B | GLY124 |
| B | ILE147 |
| B | ILE165 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"PubMed","id":"29080786","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00860","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00860","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29526431","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
