6KGO

LSD1-S2157 five-membered ring adduct model

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0016491	molecular_function	oxidoreductase activity
A	0050660	molecular_function	flavin adenine dinucleotide binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue GOL A 901

Chain	Residue
A	GLU413
A	ARG526
A	LEU544
A	ARG688
A	HOH1076

---

site_id	AC2
Number of Residues	6
Details	binding site for residue GOL A 902

Chain	Residue
A	TRP751
A	ASP754
A	ARG310
A	ARG312
A	SER749
A	ARG750

---

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL A 903

Chain	Residue
A	LYS277
A	GLN298
A	ARG608
A	HOH1029

---

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL A 904

Chain	Residue
A	GLN358
A	CYS360
A	ASN535
A	HOH1152

---

site_id	AC5
Number of Residues	2
Details	binding site for residue GOL A 905

Chain	Residue
A	ARG312
A	VAL313

---

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL A 906

Chain	Residue
A	CYS360
A	ASP375
A	GLU379
A	TRP531
A	HOH1003

---

site_id	AC7
Number of Residues	10
Details	binding site for residue TLA A 907

Chain	Residue
A	THR230
A	PHE231
A	HIS250
A	HIS253
A	GLU257
A	LYS271
A	ASN717
A	HOH1023
A	HOH1033
A	HOH1039

---

site_id	AC8
Number of Residues	42
Details	binding site for residues DJ0 A 908 and FAD A 909

Chain	Residue
A	GLY285
A	GLY287
A	VAL288
A	SER289
A	LEU307
A	GLU308
A	ALA309
A	ARG310
A	GLY314
A	GLY315
A	ARG316
A	LEU329
A	GLY330
A	ALA331
A	MET332
A	VAL333
A	THR335
A	PHE538
A	ALA539
A	THR588
A	VAL590
A	THR624
A	LEU625
A	PRO626
A	VAL637
A	LEU659
A	TRP751
A	TRP756
A	TYR761
A	GLY800
A	GLU801
A	ALA809
A	THR810
A	VAL811
A	ALA814
A	HOH1011
A	HOH1034
A	HOH1037
A	HOH1071
A	HOH1073
A	HOH1088
A	HOH1122

---

site_id	AC9
Number of Residues	42
Details	binding site for residues DJ0 A 908 and FAD A 909

Chain	Residue
A	THR624
A	LEU625
A	PRO626
A	VAL637
A	LEU659
A	TRP751
A	TRP756
A	TYR761
A	GLY800
A	GLU801
A	ALA809
A	THR810
A	VAL811
A	ALA814
A	HOH1011
A	HOH1034
A	HOH1037
A	HOH1071
A	HOH1073
A	HOH1088
A	HOH1122
A	GLY285
A	GLY287
A	VAL288
A	SER289
A	LEU307
A	GLU308
A	ALA309
A	ARG310
A	GLY314
A	GLY315
A	ARG316
A	LEU329
A	GLY330
A	ALA331
A	MET332
A	VAL333
A	THR335
A	PHE538
A	ALA539
A	THR588
A	VAL590

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:16885027, ECO:0000269|PubMed:16956976, ECO:0000269|PubMed:21300290, ECO:0000269|PubMed:23721412, ECO:0007744|PDB:2DW4, ECO:0007744|PDB:2H94, ECO:0007744|PDB:2HKO, ECO:0007744|PDB:2IW5, ECO:0007744|PDB:2V1D, ECO:0007744|PDB:2X0L, ECO:0007744|PDB:2XAF, ECO:0007744|PDB:2XAG, ECO:0007744|PDB:2XAH, ECO:0007744|PDB:2XAJ, ECO:0007744|PDB:2XAQ, ECO:0007744|PDB:2XAS, ECO:0007744|PDB:2Y48, ECO:0007744|PDB:3ZMS, ECO:0007744|PDB:3ZMT, ECO:0007744|PDB:3ZMU, ECO:0007744|PDB:3ZMV, ECO:0007744|PDB:3ZMZ, ECO:0007744|PDB:3ZN0, ECO:0007744|PDB:3ZN1

Chain	Residue	Details
A	SER289
A	GLU308
A	ARG310
A	ARG316
A	MET332
A	GLU801
A	THR810

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:27292636

Chain	Residue	Details
A	LYS432
A	LYS433
A	LYS436

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER611

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS442
A	LYS469

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:25018020

Chain	Residue	Details
A	LYS503

---