Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6KG7

Cryo-EM Structure of the Mammalian Tactile Channel Piezo2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005261	molecular_function	monoatomic cation channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
A	0009612	biological_process	response to mechanical stimulus
A	0016020	cellular_component	membrane
A	0032420	cellular_component	stereocilium
A	0032437	cellular_component	cuticular plate
A	0032809	cellular_component	neuronal cell body membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042391	biological_process	regulation of membrane potential
A	0050974	biological_process	detection of mechanical stimulus involved in sensory perception
A	0050982	biological_process	detection of mechanical stimulus
A	0071260	biological_process	cellular response to mechanical stimulus
A	0098655	biological_process	monoatomic cation transmembrane transport
B	0005261	molecular_function	monoatomic cation channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
B	0009612	biological_process	response to mechanical stimulus
B	0016020	cellular_component	membrane
B	0032420	cellular_component	stereocilium
B	0032437	cellular_component	cuticular plate
B	0032809	cellular_component	neuronal cell body membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042391	biological_process	regulation of membrane potential
B	0050974	biological_process	detection of mechanical stimulus involved in sensory perception
B	0050982	biological_process	detection of mechanical stimulus
B	0071260	biological_process	cellular response to mechanical stimulus
B	0098655	biological_process	monoatomic cation transmembrane transport
C	0005261	molecular_function	monoatomic cation channel activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006812	biological_process	monoatomic cation transport
C	0008381	molecular_function	mechanosensitive monoatomic ion channel activity
C	0009612	biological_process	response to mechanical stimulus
C	0016020	cellular_component	membrane
C	0032420	cellular_component	stereocilium
C	0032437	cellular_component	cuticular plate
C	0032809	cellular_component	neuronal cell body membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042391	biological_process	regulation of membrane potential
C	0050974	biological_process	detection of mechanical stimulus involved in sensory perception
C	0050982	biological_process	detection of mechanical stimulus
C	0071260	biological_process	cellular response to mechanical stimulus
C	0098655	biological_process	monoatomic cation transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. QIGFESLKGADAGNGI

Chain	Residue	Details
A	GLN105-ILE120

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	33
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	531
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	879
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	75
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	45
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	51
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	66
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	33
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	78
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	90
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	39
Details	Transmembrane: {"description":"Helical; Name=13","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=14","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=15","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=16","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	45
Details	Transmembrane: {"description":"Helical; Name=17","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	27
Details	Transmembrane: {"description":"Helical; Name=18","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=19","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Name=20","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=21","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	18
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	39
Details	Transmembrane: {"description":"Helical; Name=22","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=23","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=24","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=25","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	36
Details	Transmembrane: {"description":"Helical; Name=26","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	75
Details	Transmembrane: {"description":"Helical; Name=27","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	48
Details	Transmembrane: {"description":"Helical; Name=28","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=29","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	33
Details	Transmembrane: {"description":"Helical; Name=30","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=31","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=32","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	57
Details	Transmembrane: {"description":"Helical; Name=33","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=34","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	69
Details	Transmembrane: {"description":"Helical; Name=35","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	66
Details	Transmembrane: {"description":"Helical; Name=36","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	69
Details	Transmembrane: {"description":"Helical; Name=37","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	60
Details	Transmembrane: {"description":"Helical; Name=38","evidences":[{"source":"PubMed","id":"31435011","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6KG7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)