Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue D8C A 500 |
| Chain | Residue |
| A | ARG43 |
| A | PRO314 |
| A | VAL317 |
| A | NAD501 |
| A | HOH609 |
| A | TYR84 |
| A | ASN87 |
| A | LYS88 |
| A | GLN132 |
| A | LEU133 |
| A | PRO309 |
| A | GLY310 |
| A | GLY313 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | binding site for residue NAD A 501 |
| Chain | Residue |
| A | THR176 |
| A | GLY200 |
| A | ARG201 |
| A | SER202 |
| A | ASN204 |
| A | VAL205 |
| A | HIS232 |
| A | ARG233 |
| A | ALA253 |
| A | ALA254 |
| A | GLY255 |
| A | ILE256 |
| A | LEU259 |
| A | VAL274 |
| A | GLY275 |
| A | ILE276 |
| A | VAL312 |
| A | GLY313 |
| A | THR316 |
| A | D8C500 |
| A | PO4502 |
| A | HOH610 |
| A | HOH639 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 502 |
| Chain | Residue |
| A | ARG201 |
| A | ARG233 |
| A | NAD501 |
| A | HOH607 |
| A | HOH627 |
| B | ASP216 |
| B | HIS219 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue D8C B 500 |
| Chain | Residue |
| B | TYR84 |
| B | ASN87 |
| B | LYS88 |
| B | GLN132 |
| B | LEU133 |
| B | ILE276 |
| B | PRO309 |
| B | GLY310 |
| B | GLY313 |
| B | PRO314 |
| B | VAL317 |
| B | NAD501 |
| B | HOH631 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | binding site for residue NAD B 501 |
| Chain | Residue |
| B | THR176 |
| B | GLY200 |
| B | ARG201 |
| B | SER202 |
| B | ASN204 |
| B | VAL205 |
| B | HIS232 |
| B | ARG233 |
| B | ALA253 |
| B | ALA254 |
| B | GLY255 |
| B | ILE256 |
| B | LEU259 |
| B | VAL274 |
| B | GLY275 |
| B | ILE276 |
| B | VAL312 |
| B | GLY313 |
| B | THR316 |
| B | D8C500 |
| B | PO4502 |
| B | HOH632 |
| B | HOH642 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 B 502 |
| Chain | Residue |
| A | ASP216 |
| A | HIS219 |
| B | ARG201 |
| B | ARG233 |
| B | NAD501 |
| B | HOH632 |
Functional Information from PROSITE/UniProt
| site_id | PS00766 |
| Number of Residues | 26 |
| Details | THF_DHG_CYH_1 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. EeELLnlInkLNnDdnvdgLLVQLPL |
| Chain | Residue | Details |
| A | GLU110-LEU135 | |
| site_id | PS00767 |
| Number of Residues | 9 |
| Details | THF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPMTV |
| Chain | Residue | Details |
| A | PRO309-VAL317 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27899380","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16100107","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27899380","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
6KG2
