6KEJ
Crystal structure of BRD4 bromodomain 1 (BD1) in complex with 6-[2-(diethylamino)ethoxy]-16-methoxy-11-methyl-2-oxa-11-azatetracyclo[8.6.1.03,8.013,17]heptadeca-1(17),3,5,7,9,13,15-heptaen-12-one
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue D7F A 401 |
| Chain | Residue |
| A | TRP81 |
| A | PRO82 |
| A | GLN85 |
| A | LEU92 |
| A | ASP96 |
| A | TYR139 |
| A | ASN140 |
| A | HOH518 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue FMT A 402 |
| Chain | Residue |
| A | GLN62 |
| A | ASN121 |
| A | ALA122 |
| A | THR60 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue FMT A 403 |
| Chain | Residue |
| A | LYS57 |
| A | LYS99 |
| A | LYS102 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA80-TYR139 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASN140 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS99 | |
